Detailed information of TA system TA226103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1687192..1687844
• Replicon: chromosome
• Accession: NZ_CP087765
• Organism: Moraxella bovis strain SAM109246

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP096_RS08620
• Protein ID: WP_078275188.1
• Coordinates: 1687192..1687584 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP096_RS08625
• Protein ID: WP_264675982.1
• Coordinates: 1687581..1687844 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP096_RS08585 (LP096_08465)	1682284..1683225	+	942	WP_078275181.1	hydroxymethylbilane synthase	-
LP096_RS08590 (LP096_08470)	1683271..1684149	+	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP096_RS08595 (LP096_08475)	1684180..1685202	+	1023	WP_078275183.1	hypothetical protein	-
LP096_RS08600 (LP096_08480)	1685282..1685740	+	459	WP_078275184.1	acyl-CoA thioesterase	-
LP096_RS08605 (LP096_08485)	1685737..1685973	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP096_RS08610 (LP096_08490)	1685976..1686542	+	567	WP_078275186.1	hypothetical protein	-
LP096_RS08615 (LP096_08495)	1686539..1687069	-	531	WP_078275187.1	HI_0552 family protein	-
LP096_RS08620 (LP096_08500)	1687192..1687584	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP096_RS08625 (LP096_08505)	1687581..1687844	-	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP096_RS08630 (LP096_08510)	1687924..1689183	-	1260	WP_264675983.1	replication-associated recombination protein A	-
LP096_RS08635 (LP096_08515)	1689541..1689918	-	378	WP_264675984.1	hypothetical protein	-
LP096_RS08640 (LP096_08520)	1690003..1690458	+	456	WP_264675985.1	type IV secretion protein Rhs	-
LP096_RS08645 (LP096_08525)	1690523..1690795	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP096_RS08650 (LP096_08530)	1690788..1691081	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP096_RS08655 (LP096_08535)	1691225..1692559	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226103 WP_078275188.1 NZ_CP087765:c1687584-1687192 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226103 NZ_CP122301:358941-359216 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.49 Da
• Isoelectric Point: 6.3724

>AT226103 WP_264675982.1 NZ_CP087765:c1687844-1687581 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226103 NZ_CP122301:358678-358938 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA