Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1449514..1450090 Replicon chromosome
Accession NZ_CP087765
Organism Moraxella bovis strain SAM109246

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP096_RS07380 Protein ID WP_264676341.1
Coordinates 1449514..1449774 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP096_RS07385 Protein ID WP_078273964.1
Coordinates 1449755..1450090 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP096_RS07365 (LP096_07275) 1444545..1446620 + 2076 WP_264675941.1 NAD-dependent DNA ligase LigA -
LP096_RS07370 (LP096_07280) 1447133..1448518 + 1386 WP_078273966.1 APC family permease -
LP096_RS07375 (LP096_07285) 1448608..1449315 - 708 WP_264675942.1 ParA family protein -
LP096_RS07380 (LP096_07290) 1449514..1449774 + 261 WP_264676341.1 type II toxin-antitoxin system HicA family toxin Toxin
LP096_RS07385 (LP096_07295) 1449755..1450090 + 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP096_RS07390 (LP096_07300) 1450274..1450858 - 585 Protein_1454 TetR/AcrR family transcriptional regulator -
LP096_RS07395 (LP096_07305) 1451120..1452301 + 1182 WP_078274027.1 fatty acid desaturase -
LP096_RS07400 (LP096_07310) 1452947..1453714 + 768 WP_112742541.1 carbonic anhydrase family protein -
LP096_RS07405 (LP096_07315) 1453848..1454930 + 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9551.46 Da        Isoelectric Point: 4.3376

>T226102 WP_264676341.1 NZ_CP087765:1449514-1449774 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHNDN

Download         Length: 261 bp

>T226102 NZ_CP122301:310522-310890 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226102 WP_078273964.1 NZ_CP087765:1449755-1450090 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226102 NZ_CP122301:310304-310525 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References