Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 701412..702069 Replicon chromosome
Accession NZ_CP087765
Organism Moraxella bovis strain SAM109246

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP096_RS03875 Protein ID WP_264676287.1
Coordinates 701887..702069 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP096_RS03870 Protein ID WP_264676286.1
Coordinates 701412..701825 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP096_RS03815 (LP096_03760) 696515..696790 + 276 WP_112742261.1 YdaS family helix-turn-helix protein -
LP096_RS03820 (LP096_03765) 696858..697541 + 684 WP_264676189.1 Rha family transcriptional regulator -
LP096_RS03825 (LP096_03770) 697538..698428 + 891 WP_264689337.1 replication protein -
LP096_RS03830 (LP096_03775) 698425..699033 + 609 WP_078273440.1 hypothetical protein -
LP096_RS03835 (LP096_03780) 699030..699437 + 408 WP_264676695.1 VRR-NUC domain-containing protein -
LP096_RS03840 (LP096_03785) 699434..699712 + 279 WP_264676282.1 hypothetical protein -
LP096_RS03845 (LP096_03790) 699734..700024 + 291 WP_112742084.1 hypothetical protein -
LP096_RS03850 (LP096_03795) 700021..700506 + 486 WP_078273444.1 recombination protein NinB -
LP096_RS03855 (LP096_03800) 700643..700798 + 156 WP_264683498.1 hypothetical protein -
LP096_RS03860 (LP096_03805) 700795..701016 + 222 WP_264676284.1 DUF3310 domain-containing protein -
LP096_RS03865 (LP096_03810) 701000..701401 + 402 WP_264676285.1 antiterminator Q family protein -
LP096_RS03870 (LP096_03815) 701412..701825 - 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP096_RS03875 (LP096_03820) 701887..702069 - 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP096_RS03880 (LP096_03825) 702469..703173 + 705 WP_264676288.1 BRO family protein -
LP096_RS03885 (LP096_03830) 703600..703800 - 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP096_RS03890 (LP096_03835) 703837..704046 - 210 WP_264676290.1 hypothetical protein -
LP096_RS03895 (LP096_03840) 704160..704699 + 540 WP_264676291.1 terminase small subunit -
LP096_RS03900 (LP096_03845) 704699..706096 + 1398 WP_264676292.1 phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 682947..737034 54087


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226101 WP_264676287.1 NZ_CP087765:c702069-701887 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226101 NZ_CP122301:200450-200935 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226101 WP_264676286.1 NZ_CP087765:c701825-701412 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226101 NZ_CP122301:200175-200462 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References