22610

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1697623..1698158 Replicon chromosome
Accession NC_010172
Organism Methylobacterium extorquens PA1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MEXT_RS07705 Protein ID WP_012253128.1
Coordinates 1697868..1698158 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag MEXT_RS07700 Protein ID WP_012253127.1
Coordinates 1697623..1697871 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MEXT_RS07685 1692843..1694424 - 1582 Protein_1556 hypothetical protein -
MEXT_RS07690 1694424..1695791 - 1368 WP_012253125.1 SWIM zinc finger family protein -
MEXT_RS07695 1695987..1697489 - 1503 WP_042508775.1 glucose-6-phosphate dehydrogenase -
MEXT_RS07700 1697623..1697871 + 249 WP_012253127.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MEXT_RS07705 1697868..1698158 + 291 WP_012253128.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MEXT_RS07710 1698240..1698878 + 639 WP_042509154.1 uracil-DNA glycosylase family protein -
MEXT_RS07715 1698886..1700412 - 1527 WP_012253130.1 alginate export family protein -
MEXT_RS07720 1700737..1701435 + 699 WP_012253131.1 orotidine-5'-phosphate decarboxylase -
MEXT_RS07725 1701438..1701782 + 345 WP_003605408.1 DUF1330 domain-containing protein -
MEXT_RS07730 1701802..1702425 - 624 WP_012253132.1 TetR/AcrR family transcriptional regulator -
MEXT_RS07735 1702648..1702848 - 201 WP_003605412.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10921.45 Da        Isoelectric Point: 9.0225

>T22610 WP_012253128.1 NC_010172:1697868-1698158 [Methylorubrum extorquens PA1]
MSVRLSPRARADLSRIWDDSAERWGADQADCYIRLLAGGFDRLAEDPARGLGADEIRKGYFRLSVGSHILFYRLGAEGGI
EVIRILHGRMDFKRHF

Download         Length: 291 bp

>T22610 NC_010172:1697868-1698158 [Methylorubrum extorquens PA1]
ATGAGCGTCCGCCTCTCGCCGAGGGCGCGCGCGGATCTCAGCCGGATCTGGGACGATTCGGCCGAGCGCTGGGGAGCGGA
TCAGGCCGACTGCTATATCCGCCTTCTGGCTGGAGGTTTCGACCGATTGGCGGAGGATCCGGCTCGAGGTCTGGGGGCCG
ACGAGATCCGCAAGGGGTATTTCCGCCTCTCGGTGGGATCGCACATCCTGTTCTACCGCCTGGGCGCCGAGGGTGGCATC
GAGGTCATCCGCATCCTTCACGGGCGGATGGATTTCAAACGTCACTTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8974.00 Da        Isoelectric Point: 4.5173

>AT22610 WP_012253127.1 NC_010172:1697623-1697871 [Methylorubrum extorquens PA1]
MPRNTSVSLGEHFAQFIDRQVEGGRYGSASEVVRAGLRLLEEQEAALDTLRAALIEGEESGPPELFDTEAFLREKRAGAI
RG

Download         Length: 249 bp

>AT22610 NC_010172:1697623-1697871 [Methylorubrum extorquens PA1]
ATGCCGCGAAACACGTCCGTCTCGCTCGGCGAGCACTTTGCGCAGTTCATCGACCGCCAGGTCGAGGGGGGACGTTACGG
CTCCGCCAGCGAAGTCGTCCGTGCCGGACTTCGTCTTCTGGAGGAGCAGGAGGCCGCCCTCGACACGCTCCGGGCCGCGC
TGATCGAGGGGGAGGAGAGCGGCCCGCCCGAGCTCTTCGATACGGAGGCCTTTCTCCGGGAGAAGCGTGCGGGCGCGATC
CGAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References