Detailed information of TA system TA226099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 356334..356886
• Replicon: chromosome
• Accession: NZ_CP087765
• Organism: Moraxella bovis strain SAM109246

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP096_RS02020
• Protein ID: WP_029102268.1
• Coordinates: 356608..356886 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP096_RS02015
• Protein ID: WP_078273473.1
• Coordinates: 356334..356621 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP096_RS01995 (LP096_01970)	351769..352818	+	1050	WP_264676228.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP096_RS02000 (LP096_01975)	352897..354396	+	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP096_RS02005	354425..354550	+	126	WP_264676709.1	hypothetical protein	-
LP096_RS02010 (LP096_01980)	354594..356324	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP096_RS02015 (LP096_01985)	356334..356621	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP096_RS02020 (LP096_01990)	356608..356886	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP096_RS02025 (LP096_01995)	356981..357637	-	657	WP_078273472.1	YqiJ family protein	-
LP096_RS02030 (LP096_02000)	357837..358502	-	666	WP_078273471.1	PspA/IM30 family protein	-
LP096_RS02035 (LP096_02005)	358715..359005	-	291	WP_264676229.1	hypothetical protein	-
LP096_RS02040 (LP096_02010)	358998..359513	-	516	WP_115369660.1	hypothetical protein	-
LP096_RS02045 (LP096_02015)	359661..360011	-	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP096_RS02050 (LP096_02020)	360123..360899	+	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226099 WP_029102268.1 NZ_CP087765:c356886-356608 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226099 NZ_CP121861:c3844041-3843691 [Bacillus stercoris]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226099 WP_078273473.1 NZ_CP087765:c356621-356334 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226099 NZ_CP121861:c3844327-3844046 [Bacillus stercoris]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3