Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafQ-relB/YafQ-DinJ
Location 982596..983176 Replicon chromosome
Accession NZ_CP087763
Organism Lactobacillus gasseri strain Lg637

Toxin (Protein)


Gene name yafQ Uniprot ID A0A249NKC7
Locus tag LP363_RS04710 Protein ID WP_003647258.1
Coordinates 982871..983176 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A249NIV0
Locus tag LP363_RS04705 Protein ID WP_021314843.1
Coordinates 982596..982871 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP363_RS04675 (LP363_04675) 977880..978644 - 765 WP_095669638.1 nucleoside phosphorylase -
LP363_RS04680 (LP363_04680) 978659..979123 - 465 WP_230630318.1 NUDIX hydrolase -
LP363_RS04685 (LP363_04685) 979140..980333 - 1194 WP_095669636.1 MFS transporter -
LP363_RS04690 (LP363_04690) 980361..980978 - 618 Protein_920 NUDIX hydrolase -
LP363_RS04695 (LP363_04695) 981246..981728 - 483 WP_095669634.1 GNAT family N-acetyltransferase -
LP363_RS04700 (LP363_04700) 981731..982264 - 534 WP_095669633.1 GNAT family N-acetyltransferase -
LP363_RS04705 (LP363_04705) 982596..982871 + 276 WP_021314843.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LP363_RS04710 (LP363_04710) 982871..983176 + 306 WP_003647258.1 type II toxin-antitoxin system YafQ family toxin Toxin
LP363_RS04715 (LP363_04715) 983370..983507 - 138 WP_230630321.1 hypothetical protein -
LP363_RS04720 (LP363_04720) 983550..983759 - 210 WP_095669632.1 DUF3923 family protein -
LP363_RS04725 (LP363_04725) 983766..984125 - 360 WP_095669631.1 DUF6176 family protein -
LP363_RS04730 (LP363_04730) 984118..984420 - 303 WP_095669630.1 MazG-like family protein -
LP363_RS04735 (LP363_04735) 984427..984873 - 447 WP_095669629.1 N-acetyltransferase -
LP363_RS04740 (LP363_04740) 984873..985208 - 336 WP_095669628.1 hypothetical protein -
LP363_RS04745 (LP363_04745) 985347..986924 + 1578 WP_095669627.1 ABC transporter ATP-binding protein -
LP363_RS04750 (LP363_04750) 986971..987453 - 483 WP_095669626.1 nitroreductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-88)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11985.87 Da        Isoelectric Point: 10.2029

>T226095 WP_003647258.1 NZ_CP087763:982871-983176 [Lactobacillus gasseri]
MAQINYTPQFKRDYKKLKRKHYDLNKLKNVIQLLIDEKFKILVDKYDDHQLKGSLRSLRALHVEHNKAGNWILVYKIHSG
NLELLTIDLVSTGSHDHTYRT

Download         Length: 306 bp

>T226095 NZ_CP121861:2134909-2135085 [Bacillus stercoris]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCA
AACGTATACGCAGATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10461.79 Da        Isoelectric Point: 4.8096

>AT226095 WP_021314843.1 NZ_CP087763:982596-982871 [Lactobacillus gasseri]
MTTTVSLRLPEDLKKQATDVFNEYGLDWSSAMRMILTQVVSENAIPVNLHRYSEISPSMKSNIDRSLQEYKAGNYKTTNS
VKELFEELDKD

Download         Length: 276 bp

>AT226095 NZ_CP121861:c2134968-2134871 [Bacillus stercoris]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249NKC7

Antitoxin

Source ID Structure
AlphaFold DB A0A249NIV0

References