Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafQ-relB/YafQ-DinJ
Location 975542..976122 Replicon chromosome
Accession NZ_CP087761
Organism Lactobacillus gasseri strain Lg1266

Toxin (Protein)


Gene name yafQ Uniprot ID A0A249NKC7
Locus tag LP361_RS04595 Protein ID WP_003647258.1
Coordinates 975817..976122 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A249NIV0
Locus tag LP361_RS04590 Protein ID WP_021314843.1
Coordinates 975542..975817 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP361_RS04560 (LP361_04560) 971421..972311 - 891 WP_003647264.1 GRP family sugar transporter -
LP361_RS04565 (LP361_04565) 972338..972733 - 396 WP_003647263.1 D-ribose pyranase -
LP361_RS04570 (LP361_04570) 972842..973291 - 450 WP_003647262.1 ASCH domain-containing protein -
LP361_RS04575 (LP361_04575) 973294..974058 - 765 Protein_895 nucleoside phosphorylase -
LP361_RS04580 (LP361_04580) 974185..974673 - 489 WP_003647261.1 GNAT family N-acetyltransferase -
LP361_RS04585 (LP361_04585) 974676..975209 - 534 WP_003647260.1 GNAT family N-acetyltransferase -
LP361_RS04590 (LP361_04590) 975542..975817 + 276 WP_021314843.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LP361_RS04595 (LP361_04595) 975817..976122 + 306 WP_003647258.1 type II toxin-antitoxin system YafQ family toxin Toxin
LP361_RS04600 (LP361_04600) 976285..977100 - 816 WP_003647256.1 Fic family protein -
LP361_RS04605 (LP361_04605) 977245..978033 - 789 WP_003647255.1 tyrosine-protein phosphatase -
LP361_RS04610 (LP361_04610) 978102..978371 - 270 WP_225792982.1 hypothetical protein -
LP361_RS04615 (LP361_04615) 978406..979125 - 720 WP_003647253.1 hypothetical protein -
LP361_RS04620 (LP361_04620) 979132..979491 - 360 WP_003647252.1 DUF6176 family protein -
LP361_RS04625 (LP361_04625) 979484..979786 - 303 WP_003647251.1 MazG-like family protein -
LP361_RS04630 (LP361_04630) 979798..980607 - 810 WP_003647250.1 DUF2785 domain-containing protein -
LP361_RS04635 (LP361_04635) 980610..981057 - 448 Protein_907 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-88)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11985.87 Da        Isoelectric Point: 10.2029

>T226094 WP_003647258.1 NZ_CP087761:975817-976122 [Lactobacillus gasseri]
MAQINYTPQFKRDYKKLKRKHYDLNKLKNVIQLLIDEKFKILVDKYDDHQLKGSLRSLRALHVEHNKAGNWILVYKIHSG
NLELLTIDLVSTGSHDHTYRT

Download         Length: 306 bp

>T226094 NZ_CP121859:1378755-1380074 [Aeromonas veronii]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTAGCACAACCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAACCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGAAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGACGTTCCAGATGTCAGGCGAATCGACTACAAAGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGAGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATCTCGATGACCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTACCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAACCATGGAGGACCGGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTATTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAAAACTTCTCGGTCTTTATT
GAGCCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTATTTGGCGGTCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACACAGCAATTGCCAGCAGGCTTCCCCGATACCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10461.79 Da        Isoelectric Point: 4.8096

>AT226094 WP_021314843.1 NZ_CP087761:975542-975817 [Lactobacillus gasseri]
MTTTVSLRLPEDLKKQATDVFNEYGLDWSSAMRMILTQVVSENAIPVNLHRYSEISPSMKSNIDRSLQEYKAGNYKTTNS
VKELFEELDKD

Download         Length: 276 bp

>AT226094 NZ_CP121859:1378501-1378755 [Aeromonas veronii]
ATGAAAGTAACCAGCGCCAAACAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCAGCGCTTGAATTGTCAGTGGATATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249NKC7

Antitoxin

Source ID Structure
AlphaFold DB A0A249NIV0

References