Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5123544..5124199 Replicon chromosome
Accession NZ_CP087719
Organism Roseomonas sp. OT10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LPC08_RS23310 Protein ID WP_230450603.1
Coordinates 5123795..5124199 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LPC08_RS23305 Protein ID WP_230450602.1
Coordinates 5123544..5123792 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC08_RS23285 (LPC08_23285) 5119548..5120084 + 537 WP_230450598.1 hypothetical protein -
LPC08_RS23290 (LPC08_23290) 5120081..5121412 + 1332 WP_230450599.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
LPC08_RS23295 (LPC08_23295) 5121570..5122049 - 480 WP_230450600.1 glutathione peroxidase -
LPC08_RS23300 (LPC08_23300) 5122097..5123392 - 1296 WP_230450601.1 esterase-like activity of phytase family protein -
LPC08_RS23305 (LPC08_23305) 5123544..5123792 + 249 WP_230450602.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LPC08_RS23310 (LPC08_23310) 5123795..5124199 + 405 WP_230450603.1 type II toxin-antitoxin system VapC family toxin Toxin
LPC08_RS23315 (LPC08_23315) 5124196..5125032 + 837 WP_230450604.1 HNH endonuclease signature motif containing protein -
LPC08_RS23320 (LPC08_23320) 5125122..5125709 + 588 WP_230450605.1 transposase -
LPC08_RS23325 (LPC08_23325) 5125819..5127054 + 1236 WP_230450606.1 argininosuccinate synthase -
LPC08_RS23330 (LPC08_23330) 5127095..5127319 - 225 WP_230450607.1 hypothetical protein -
LPC08_RS23335 (LPC08_23335) 5127420..5128295 - 876 WP_230450608.1 DMT family transporter -
LPC08_RS23340 (LPC08_23340) 5128301..5129161 - 861 WP_230450609.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(14-50)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14060.06 Da        Isoelectric Point: 5.1647

>T226093 WP_230450603.1 NZ_CP087719:5123795-5124199 [Roseomonas sp. OT10]
VRYMLDTNIVSDIIRNPLGAAAQRARAEGDAVCVSVIVAAELRYGCARKGSPKLTRRVAQFLAEVPVLPFDAPADEAYGT
LRAELEAAGRPIGGNDLLIAAHASALGATVVTANLGEFVRVPGLNAENWMETSG

Download         Length: 405 bp

>T226093 NZ_CP121856:c4377758-4376439 [Aeromonas veronii]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTAGCACAACCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAACCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGAAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGACGTTCCAGATGTCAGGCGAATCGACTACAAAGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGAGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATCTCGATGACCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTACCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAACCATGGAGGACCGGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTATTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAAAACTTCTCGGTCTTTATT
GAGCCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTATTTGGCGGTCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACACAGCAATTGCCAGCAGGCTTCCCCGATACCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9353.67 Da        Isoelectric Point: 4.3895

>AT226093 WP_230450602.1 NZ_CP087719:5123544-5123792 [Roseomonas sp. OT10]
MPSPAPASRQVRLFRNNRNQAIRIPVEFELPGEEAIITRDGDRLIIEPVRRRGLAALLDSWEPLDEELPEPEDLPLAPKD
VF

Download         Length: 249 bp

>AT226093 NZ_CP121856:c4378012-4377758 [Aeromonas veronii]
ATGAAAGTAACCAGCGCCAAACAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCAGCGCTTGAATTGTCAGTGGATATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References