Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4994364..4994995 Replicon chromosome
Accession NZ_CP087719
Organism Roseomonas sp. OT10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LPC08_RS22745 Protein ID WP_230450500.1
Coordinates 4994585..4994995 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LPC08_RS22740 Protein ID WP_230450499.1
Coordinates 4994364..4994588 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC08_RS22720 (LPC08_22720) 4990540..4991187 + 648 WP_230450495.1 hypothetical protein -
LPC08_RS22725 (LPC08_22725) 4991164..4991973 - 810 WP_230450496.1 hypothetical protein -
LPC08_RS22730 (LPC08_22730) 4992147..4992938 + 792 WP_230450497.1 enoyl-CoA hydratase/isomerase family protein -
LPC08_RS22735 (LPC08_22735) 4992964..4994151 + 1188 WP_230450498.1 benzoate/H(+) symporter BenE family transporter -
LPC08_RS22740 (LPC08_22740) 4994364..4994588 + 225 WP_230450499.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LPC08_RS22745 (LPC08_22745) 4994585..4994995 + 411 WP_230450500.1 type II toxin-antitoxin system VapC family toxin Toxin
LPC08_RS22750 (LPC08_22750) 4995686..4995997 + 312 WP_230450501.1 hypothetical protein -
LPC08_RS22755 (LPC08_22755) 4996092..4996910 + 819 WP_230450502.1 phosphonate ABC transporter ATP-binding protein -
LPC08_RS22760 (LPC08_22760) 4996963..4997889 + 927 WP_230450503.1 phosphonate ABC transporter substrate-binding protein -
LPC08_RS22765 (LPC08_22765) 4997957..4998850 + 894 WP_230450504.1 phosphonate ABC transporter, permease protein PhnE -
LPC08_RS22770 (LPC08_22770) 4998847..4999743 + 897 WP_230450505.1 phosphonate ABC transporter, permease protein PhnE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(9-44)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14999.11 Da        Isoelectric Point: 6.9325

>T226092 WP_230450500.1 NZ_CP087719:4994585-4994995 [Roseomonas sp. OT10]
VTPRYLLDTNLCIRVLRDRPAGLRERFNAEAEALCTSEVVRYELLYGAERSARPAEVRREVERFAARLAVLPFDDAAAAH
TAQIRAELERQGAVIGPYDLMIAGQARSRGLVVVTGNLGEFGRVAGLRCEDWLAGS

Download         Length: 411 bp

>T226092 NZ_CP121851:c4378431-4377112 [Aeromonas veronii]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTAGCACAACCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAACCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGAAACAGGGTTGTAGCACGCTATCAA
GCAGCATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGATGTTCTAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATATCGATGGCCGTTGGTACTTGCCACTCAAAGCAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATATCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAAGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAGGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCAGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCCTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGTGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAGGAAGTACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAACTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACGCCGTT
GATGATGTTATTGAACGCGTGACCCGGCAATTGCCGGCAGACTTCCCCGATGCCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8177.36 Da        Isoelectric Point: 6.2652

>AT226092 WP_230450499.1 NZ_CP087719:4994364-4994588 [Roseomonas sp. OT10]
MPTRTTLFLSNRSQAVRLPKGVAFEAGVREVVILRDGVRRVIAPADAAWDDFFAAPGVDLGERQQPPMQDREAL

Download         Length: 225 bp

>AT226092 NZ_CP121851:c4378685-4378431 [Aeromonas veronii]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCAGCACTCGAATTGTCAGTGGATATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References