Detailed information of TA system TA226086

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1228968..1229487
• Replicon: chromosome
• Accession: NZ_CP087716
• Organism: Acinetobacter pittii strain AP2044

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LPS07_RS06065
• Protein ID: WP_069119604.1
• Coordinates: 1228968..1229249 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B5UBP1
• Locus tag: LPS07_RS06070
• Protein ID: WP_029424561.1
• Coordinates: 1229239..1229487 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPS07_RS06035 (LPS07_06035)	1224023..1225225	+	1203	WP_069119584.1	tyrosine-type recombinase/integrase	-
LPS07_RS06040 (LPS07_06040)	1225251..1225631	+	381	WP_069119590.1	hypothetical protein	-
LPS07_RS06045 (LPS07_06045)	1226147..1226901	+	755	Protein_1167	phage/plasmid replication protein, II/X family	-
LPS07_RS06050 (LPS07_06050)	1226956..1227126	+	171	WP_230445239.1	AlpA family transcriptional regulator	-
LPS07_RS06055 (LPS07_06055)	1227203..1227607	-	405	WP_069119600.1	helix-turn-helix transcriptional regulator	-
LPS07_RS06060 (LPS07_06060)	1228021..1228677	+	657	WP_139118976.1	hypothetical protein	-
LPS07_RS06065 (LPS07_06065)	1228968..1229249	-	282	WP_069119604.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPS07_RS06070 (LPS07_06070)	1229239..1229487	-	249	WP_029424561.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LPS07_RS06075 (LPS07_06075)	1229490..1229879	-	390	WP_228143317.1	hypothetical protein	-
LPS07_RS06080 (LPS07_06080)	1229938..1230534	-	597	WP_057061462.1	recombinase family protein	-
LPS07_RS06085 (LPS07_06085)	1231066..1232589	+	1524	WP_069119608.1	adenylate/guanylate cyclase domain-containing protein	-
LPS07_RS06090 (LPS07_06090)	1232573..1233331	+	759	WP_069119610.1	hypothetical protein	-
LPS07_RS06095 (LPS07_06095)	1233351..1234268	+	918	WP_069119612.1	nucleotide-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	blaADC-25	bauF / basA / basB / bauD / bauC / bauE / bauB / basC / basD / entE / basF / basG / barA / barB / basH / basI / basJ	1113913..1280888	166975

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10817.62 Da
• Isoelectric Point: 10.1967

>T226086 WP_069119604.1 NZ_CP087716:c1229249-1228968 [Acinetobacter pittii]
MSYNLDFLEEALEEWNKLNPSIKQPMKKKLMKVLENPRIPKNKLSGHPNRYKVKLRSVGYRLVYEVIDDEVVVLVIAVGK
RENNAVYNTASSR

Nucleotide

• Length: 282 bp

>T226086 NZ_CP121801:c4558589-4557936 [Aeromonas dhakensis]
ATGGCCTATGACTATAGCCAGAGCCTGAATCCGCAGAAGGCGCTGATATTCCGGATCGTGCATCGGGATAACCTGGAATG
GATCCTGACCCATGGCCTGTGGGCGGGGAATGGTCAGCAGCAAAACCCGCACTGGGTGCATATCGGGCTGCCGGAGCTGA
TTGCCAAGCGCGCACGCCATCCGGTGCCGCTGGCGCCTTACGGCGTGTTGAATGACTATGTACCCTTCTACTTCACGCCG
TTTTCGCCCATGCTCAGCAATATTCACTCGGGGCGCGGTGTTCCCCGGCGTGAAAATGATGAAATCCTGATCCTGGTTTC
CAGCCTGCATCGCATGGCTGAATTGGGGCTACCGTTTGTGTTTACCGATAGCCATGCCTATTACCAGTGGGCCAATTTCT
ATGTCGACCTTGGCGATCTGGGGCGGATTGACTGGCCACTGTTGCAGCGCCGTGACTTCAAGCGTGATGCGGACGATTTG
AGCAAGCTGGAACGCTATCAGGCCGAGGCCTTGATCCATCAACATTGCCCCATCGAGGCGTTGCTGGGCGTGGTGTGTTA
CAACGAAGAAATAAAGAACAGCGTGGAACAATGCATGAATCGGGTCGGGATCGCGCGCCCCGTCTATGTCCGTGATGGGT
GGTATTTCAGATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9272.74 Da
• Isoelectric Point: 5.8061

>AT226086 WP_029424561.1 NZ_CP087716:c1229487-1229239 [Acinetobacter pittii]
MTQLIHARMTASITELKKSPMDTVLAGKGEAVAILNRNTPAFYCIPADLYENMIEQLEDLELNKIADTRANQKRIRVNIN
EL

Nucleotide

• Length: 249 bp

>AT226086 NZ_CP121801:c4557939-4556875 [Aeromonas dhakensis]
ATGATTCGATATACAACAGGCAATCTGCTGGATGCTCCGGTGGAAGCGCTGGTGAATACCGTCAACACCGTCGGTGTCAT
GGGCAAGGGGATCGCCTTGATGTTCAAGGAGCGGTTCCCGGCCAATATGCGCGCCTATGCCGAGGCGTGCAAACAGTGTG
ATGTCGTCACCGGCAAGATGTTTATTACCCAGACGGGTGAGCTGCTGGGGCCGCGCTGGATCGTGAATTTTCCGACCAAA
CAGCACTGGCGCAATCCGGCACAGATGGCGTGGATCCAGGATGGTTTGCAGGATCTACGGGCCTGGTTACAGGCGCAGCA
GGTCTCTTCGATTGCCATTCCGCCGCTGGGGGCTGGCAACGGTGGTCTGCCTTGGCCAGAGGTCAAACAGGCGATTGAAA
CGGCACTGGGCGATCTGGATATCGATATCCTGCTCTATGAGCCCAGTAGCCAATACCAAAATGTGGCCAAGCGGGGCGGG
GTGGCGGAGCTGACTCCGGCTCGGGCCTTGATTGCTGAACTGGTACGCCGCTACTGGTTTTTAGGAATGGAGTGCAGCTT
GCTGGAGATCCAGAAACTGGCCTGGTTTCTGGCTCGGGTCATTGGCCGTAACCCGCTGGGGGATCCGCTGCAGTTGCAGT
TTAAGGCCCATCGTTATGGCCCTTATGCCAACAATCTGACCCATCTGCTCAATGCGATGGACGGCAGTTATCTGCAGTCC
GACAAGCGCATTCCGGATAGCAAGCCGTTTGATGTCATCTGGTTTAATGAGGCCAAAAAACAAGAGCTTGCCGTTTATCT
CCAGACCGAGGCCAAAGCATTTTTACCGATACTGGAGCAGACGACCGCGTTAATCGATGGTTTTGAGTCGCCCTATGGCA
TGGAGTTATTGGCCACGGTCGATTGGTTGATCGCCGAAGAGGGCTGTGCGCCGACGCTGAGCGCGCTGCGAGAGGGGTTG
CATCGCTGGCCAGCGGGAACCCCGTGGGGTGAGCGCAAGGCGCGGCTGTTTGATGATCGCAGTCTGCAGATCGCCTTGAA
CCGTTTGCAGCAGGGATTGGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A8B5UBP1