Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2935496..2936292 Replicon chromosome
Accession NZ_CP087711
Organism Plesiomonas shigelloides strain 7A

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag LPH35_RS13025 Protein ID WP_230432219.1
Coordinates 2935795..2936292 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag LPH35_RS13020 Protein ID WP_116547297.1
Coordinates 2935496..2935795 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPH35_RS12985 2930868..2931329 - 462 WP_230432209.1 hypothetical protein -
LPH35_RS12990 2931329..2932153 - 825 WP_230432211.1 AAA family ATPase -
LPH35_RS12995 2932499..2932759 + 261 WP_230432212.1 hypothetical protein -
LPH35_RS13000 2932864..2933394 - 531 WP_230432214.1 hypothetical protein -
LPH35_RS13005 2933782..2934036 + 255 WP_230432216.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
LPH35_RS13010 2934029..2934298 + 270 WP_010863491.1 Txe/YoeB family addiction module toxin -
LPH35_RS13015 2934554..2935156 - 603 WP_230432218.1 hypothetical protein -
LPH35_RS13020 2935496..2935795 + 300 WP_116547297.1 DUF1778 domain-containing protein Antitoxin
LPH35_RS13025 2935795..2936292 + 498 WP_230432219.1 GNAT family N-acetyltransferase Toxin
LPH35_RS13030 2936465..2937028 - 564 WP_230432221.1 DUF922 domain-containing protein -
LPH35_RS13035 2937524..2938141 + 618 WP_230432222.1 nucleotidyltransferase domain-containing protein -
LPH35_RS13040 2938462..2939220 - 759 WP_230432224.1 DUF2971 domain-containing protein -
LPH35_RS13045 2939631..2939969 - 339 WP_152116948.1 DUF5713 family protein -
LPH35_RS13050 2940475..2940954 - 480 WP_230432226.1 GIY-YIG nuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(11-99)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18311.32 Da        Isoelectric Point: 9.9151

>T226084 WP_230432219.1 NZ_CP087711:2935795-2936292 [Plesiomonas shigelloides]
MIISKPEVLSKEHRVESFDCGNLSLNEWLIRHSRQAQSSGSAKTFVVTDSGSVVGYFSLTVGQVDTYEVPERVRQGMGQY
PIPVVILARLAVSIKYQKMGIGVGLLQDAIKRTVLIAEQVGIRALLTHPIDNAAAQFYEQFGFVASPVREKQLVLLLKDA
RKLLR

Download         Length: 498 bp

>T226084 NZ_CP121800:2428575-2429885 [Aeromonas dhakensis]
ATGGCCAGCCTGACGGTCTACATGAACGGATACCGGGTAGGTACCTTTACCAAGGCGACCAATGGTGCTCACCAATTTCA
GTACGATGAATCGTGGGTGAAGTTGCCAGGCAGCCGCCCCATCTCGCTCTCCATGCCATTACGCCAGCAGCGCTACCAGG
GCGATGAGGCCTATAACTTCTTCGATAATCTGCTGCCAGATAACCCGGAAGTAAGAAACCGGGTGGTGGCGCGCTATCAA
GCCGATTCCACCCAACCCTTTGATCTGCTCAGTTGTATTGGCCAGGACAGCGTGGGGGCATTGCAACTGGTGGCTCAGGG
CAGACCTGTGCCAGACGTTAAGCGCATTGAGTGCAAGCCGCTCTCTGACGCCGAACTGGAGCAGATCATGACCAGCTACC
AGCAAGGGATCCCGCTTGGTATGGTGAGGGAAGAGGACGATTTTCGGATATCCATCGCCGGGGCTCAGGAAAAGACCGCG
TTACTCTACCTCGACAACCGTTGGTGCTTACCGCATGCAGCGACCCCAACCACCCACATTATCAAGCTGCCCATTGGCAA
GATCGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACCCTGATCGCCAAAGCAT
TGGGTCTTCCGGTTCCCCATTGCTTCATCATGCAGGTCGGCAAGGTCAAGGCTCTGGCGGTGGAACGCTTCGATCGGCGC
TACGCCACGGATCGCAGTTGGATCATGCGCCTGCCCCAAGAGGACTTCTGCCAGGTGTTGAATGTACCGTCAGCACGCAA
GTACGAGAGCCATGGTGGACCGGGCATTGCTGACATCATGACGACCCTGCTGGGATCGGCCACGCCGGAGCAGGATCGGT
ACCTGTTTATGAAGTCTCAGGTGTTGTTCTGGCTGCTGGCTGCCACTGATGGCCATGCCAAGAATTTCTCGGTGTTTATC
GAACCTGAAGGGCGTTTCCGGCTTACACCGTTTTACGACATCCTTTCCATGTATCCTGCATTTGGTGGTAAAGGATTACA
TCCCCGTGATGCCAAGTTGGCCATGGGGCTTACTGCAACCAAGGGCAAAAAATACGCGATAGAGCAGATATTTCCTCGCC
ATTTTTATCAAACGGCCAAGGCGATTGGTTTTGAACAAGTGCAGATGGAAAAAATCATCAGCGAACTGACGGATAATCTG
GATGAGGTAATATCAATCGTTCGTCAGCAATTGCCTGATACATTTCCCACTGAGATTGCAGATTCAATTTTGGGTGGACT
CAGTTCGAAAGCGCAACGCTTAAAACGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11057.51 Da        Isoelectric Point: 5.7092

>AT226084 WP_116547297.1 NZ_CP087711:2935496-2935795 [Plesiomonas shigelloides]
MPNCASVPASRSVRTARLGLRATPEQEAVLRRAADIAHKSLTDFILDSACHAAEQALLDQRLFVTSGEQYKTFLDMLDQP
EKENEGLNDLFARKAPWDK

Download         Length: 300 bp

>AT226084 NZ_CP121800:2428321-2428575 [Aeromonas dhakensis]
ATGAAAGTAACCAGCGCCAAGCAACTTAGTGCCTGTCTCAAGGATGCCAGGCTTTCGCAAAAGCTCTCCCAAGGCAAAGT
GGCCGGCAAGGTGGGGATCAGGCAGGACACGGTGTCCAGCTTCGAGCTCAATCCCGAGTCAACCAAGCTGGAGACCTTGT
TCAAGATCCTCGCCGCACTGGAACTCTCCCTCGATATCAGGCCCCGCACCGATCCTGCGGAAAACGCCACGCCTGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References