226078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4888940..4890621 Replicon chromosome
Accession NZ_CP087706
Organism Klebsiella pneumoniae strain YZH2487

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag LO768_RS24050 Protein ID WP_002885155.1
Coordinates 4888940..4889857 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2L1C4M5
Locus tag LO768_RS24055 Protein ID WP_004192584.1
Coordinates 4889863..4890621 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO768_RS24030 (4884246) 4884246..4885766 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
LO768_RS24035 (4885763) 4885763..4886761 + 999 WP_002885172.1 ribose ABC transporter permease -
LO768_RS24040 (4886792) 4886792..4887733 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
LO768_RS24045 (4887808) 4887808..4888815 + 1008 WP_004177805.1 carbohydrate kinase family protein -
LO768_RS24050 (4888940) 4888940..4889857 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LO768_RS24055 (4889863) 4889863..4890621 - 759 WP_004192584.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LO768_RS24060 (4890707) 4890707..4891435 - 729 WP_002885152.1 response regulator transcription factor -
LO768_RS24065 (4891708) 4891708..4893855 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
LO768_RS24070 (4894085) 4894085..4894771 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T226078 WP_002885155.1 NZ_CP087706:c4889857-4888940 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T226078 NZ_CP121794:c1956638-1955652 [Aeromonas caviae]
ATGGCTAACCTTTGGGTATACATGAACGGTTACCGAGTGGGTACCTTTACCATGACAACTAGCGGTGCCCACCAATTTCA
GTACGATGAGTCTTGGGTAACACTGCCGGGTAGCCGCCCCATTTCTCTCTCTATGCCGTTACGGCAGCAGTGCTATCGAG
GCGATGAGCCCTATAACTTCTTCGGCAACTTGTTGCCGGATAATCTAGAAGTAAAAAACCGGGTGGTAGCACGCTACCAA
GCCAACTCAACCCAATCTTTTGATCTGCTCAGCTGCATTGGTCAGGACTGCGTAGGTGCATTGCAACTGGTGGCTCAGGG
TGCCCCTACGCCTGATGTGAAACGCATCGAATGTAAACCGCTCTCTGATGCTGAACTGGAGCATATCCTGACTAGTTACC
AACAAGGGATCCCTCTTGGGATGGTCAGGGAAGTTGAGGATTTCCGGATCTCTATCGCCGGGGCTCAGGAAAAGACCGCG
CTACTCTATCGTGACAACCGCTGGTACTTACCGAGTGCTGCGACCCCAACCACCCATATCATCAAGTTACCCATTGGTAA
GATCGAGAGCCACTCTTACTCGATAGATCTCTCCCAGAGCGTGGAGAACGAGTATCTCTGTACCCTGATAGCTAAAGAGT
TTGGTCTTCCCGTCCCGCATTGCTTCATTATGCAGGTAGGTAAAATCAAGGCTTTGGCAGTGGAGCGCTTCGATCGACGC
TACGCCGCTGATCGTAGCTGGATCATGCGTCTACCCCAAGAGGACTTCTGCCAAGTATTGAATGTACCGTCAGTACGGAA
GTACGAGAGCCATGGTGGGCCGAGTATTGCTGACATCATGACGACCCTGTTGGGGTCTGCCACACCGGAGCAGGATCGTT
ACCTGTTTATGAAGTCTCAAGTGCTGTTCTGGCTGCTGGCCGCGACTGACGGTCATGCAAAGAACTTCTCGGTCTTTATA
GAACCGGGGGGGGAAGCTTCCGACTGA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT226078 WP_004192584.1 NZ_CP087706:c4890621-4889863 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT226078 NZ_CP121794:c1956892-1956638 [Aeromonas caviae]
ATGAAAGTAACCAGCGCGAAGCAGCTTAGTGCCTACCTCAAAGATGCCAGGCTTTTGCAAAAATATTCTCAGGGCAAGGT
TGCCGACAAGGTTGGCATCAGACAAGACACCGTCTCCAATTTTGAGCTCAATCCAGAATCAACCAAGTTGGATACCTTGT
TCAAAATCCTCGCCGCGTTGGAACTATCCCTTGATATCAAGCCTCGAACCGATCCACCGGATAGCCCTTCCTCAGGCTGG
AAAGAGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1C4M5

References