Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 4638156..4638826 | Replicon | chromosome |
| Accession | NZ_CP087706 | ||
| Organism | Klebsiella pneumoniae strain YZH2487 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A483GLH7 |
| Locus tag | LO768_RS22825 | Protein ID | WP_023301398.1 |
| Coordinates | 4638156..4638488 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A483GII7 |
| Locus tag | LO768_RS22830 | Protein ID | WP_023301397.1 |
| Coordinates | 4638509..4638826 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LO768_RS22800 (4633381) | 4633381..4634053 | + | 673 | Protein_4470 | DUF4400 domain-containing protein | - |
| LO768_RS22805 (4634064) | 4634064..4634948 | + | 885 | WP_004192285.1 | RES domain-containing protein | - |
| LO768_RS22810 (4635147) | 4635147..4635335 | - | 189 | Protein_4472 | transposase | - |
| LO768_RS22815 (4635352) | 4635352..4636463 | - | 1112 | Protein_4473 | IS3 family transposase | - |
| LO768_RS22820 (4636862) | 4636862..4637722 | - | 861 | WP_023301399.1 | hypothetical protein | - |
| LO768_RS22825 (4638156) | 4638156..4638488 | - | 333 | WP_023301398.1 | TA system toxin CbtA family protein | Toxin |
| LO768_RS22830 (4638509) | 4638509..4638826 | - | 318 | WP_023301397.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LO768_RS22835 (4638845) | 4638845..4639066 | - | 222 | WP_023301396.1 | DUF987 domain-containing protein | - |
| LO768_RS22840 (4639075) | 4639075..4639557 | - | 483 | WP_023301395.1 | RadC family protein | - |
| LO768_RS22845 (4639566) | 4639566..4640024 | - | 459 | WP_023301394.1 | antirestriction protein | - |
| LO768_RS22850 (4640110) | 4640110..4640346 | - | 237 | WP_032446575.1 | DUF905 domain-containing protein | - |
| LO768_RS22855 (4640424) | 4640424..4640834 | - | 411 | WP_023301393.1 | hypothetical protein | - |
| LO768_RS22860 (4640901) | 4640901..4641338 | - | 438 | WP_023301392.1 | hypothetical protein | - |
| LO768_RS22865 (4641380) | 4641380..4641916 | - | 537 | WP_023301391.1 | DUF4339 domain-containing protein | - |
| LO768_RS22870 (4641942) | 4641942..4642652 | - | 711 | WP_023301390.1 | DeoR family transcriptional regulator | - |
| LO768_RS22875 (4642861) | 4642861..4643685 | - | 825 | WP_023301389.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4627226..4667831 | 40605 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12610.65 Da Isoelectric Point: 5.6692
>T226076 WP_023301398.1 NZ_CP087706:c4638488-4638156 [Klebsiella pneumoniae]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM
Download Length: 333 bp
>T226076 NZ_CP121769:1993488-1993832 [Glaesserella parasuis]
ATGACTACTCAAGAGTATATCCCTGACGTTGGTGATATTATTTGGCTTGATTTTGATCCGCAAGCAGGACATGAACAAGC
TGGTCATCGTCCAGCATTAGTGTTAACGCCCACGATTTATAATCGTCAAACAGGGTTGTTAATTTGTTGCCCGCTCACAA
CGAAAGTAAAAGGCTATCCTTTCGAAGTCAATATTGCAGGTACCCCCCAAAATGTTGTGCTTTCCGATCAAATTAAAAGC
CTTGACTGGCGTATTCGTCACGCTAAATTTAAAGGTAAAATTAACCATCATCAGTTAAGCGAAGTAAAAGCTAAAATTGC
GACTTTGCTACAAATCAGTGAATAA
ATGACTACTCAAGAGTATATCCCTGACGTTGGTGATATTATTTGGCTTGATTTTGATCCGCAAGCAGGACATGAACAAGC
TGGTCATCGTCCAGCATTAGTGTTAACGCCCACGATTTATAATCGTCAAACAGGGTTGTTAATTTGTTGCCCGCTCACAA
CGAAAGTAAAAGGCTATCCTTTCGAAGTCAATATTGCAGGTACCCCCCAAAATGTTGTGCTTTCCGATCAAATTAAAAGC
CTTGACTGGCGTATTCGTCACGCTAAATTTAAAGGTAAAATTAACCATCATCAGTTAAGCGAAGTAAAAGCTAAAATTGC
GACTTTGCTACAAATCAGTGAATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11785.37 Da Isoelectric Point: 6.6277
>AT226076 WP_023301397.1 NZ_CP087706:c4638826-4638509 [Klebsiella pneumoniae]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR
Download Length: 318 bp
>AT226076 NZ_CP121769:1993252-1993491 [Glaesserella parasuis]
ATGCAAGTGGCTGTCAAAAAATGGGGAAATAGCGTAGGCATTCGCATTCCTGCTTTATTATCTAATTCATTGAAATTACA
GGCAGAGAGTTTAGTCGATATTCAAGAAGTTGATGGTCGCCTAATTATTGAGCCGATTAAACCTAAATATAATTTAGAGC
AACTTCTTTCGGGTATTACTGAAGATAATTTGCACAATGAAGTCGATTTTGGCAAGCCTGTTGGCAAGGAAATGCTATGA
ATGCAAGTGGCTGTCAAAAAATGGGGAAATAGCGTAGGCATTCGCATTCCTGCTTTATTATCTAATTCATTGAAATTACA
GGCAGAGAGTTTAGTCGATATTCAAGAAGTTGATGGTCGCCTAATTATTGAGCCGATTAAACCTAAATATAATTTAGAGC
AACTTCTTTCGGGTATTACTGAAGATAATTTGCACAATGAAGTCGATTTTGGCAAGCCTGTTGGCAAGGAAATGCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A483GLH7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A483GII7 |