226074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4001727..4002346 Replicon chromosome
Accession NZ_CP087706
Organism Klebsiella pneumoniae strain YZH2487

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LO768_RS19720 Protein ID WP_002892050.1
Coordinates 4002128..4002346 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LO768_RS19715 Protein ID WP_002892066.1
Coordinates 4001727..4002101 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO768_RS19705 (3996879) 3996879..3998072 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LO768_RS19710 (3998095) 3998095..4001241 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LO768_RS19715 (4001727) 4001727..4002101 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LO768_RS19720 (4002128) 4002128..4002346 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LO768_RS19725 (4002509) 4002509..4003075 + 567 WP_002892030.1 maltose O-acetyltransferase -
LO768_RS19730 (4003047) 4003047..4003187 - 141 WP_004147370.1 hypothetical protein -
LO768_RS19735 (4003208) 4003208..4003678 + 471 WP_002892026.1 YlaC family protein -
LO768_RS19740 (4003653) 4003653..4005104 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LO768_RS19745 (4005205) 4005205..4005903 + 699 WP_002892021.1 GNAT family protein -
LO768_RS19750 (4005900) 4005900..4006040 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LO768_RS19755 (4006040) 4006040..4006303 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T226074 WP_002892050.1 NZ_CP087706:4002128-4002346 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T226074 NZ_CP121769:1501589-1501867 [Glaesserella parasuis]
ATGATTATTTCATTTAAGCATAAAGGATTGAAATTATTTTTTGAAACAGGATCAACTGCAGGTATTCAGGCAAATCACGC
TAGTAAACTTGCTTTTCAATTAGCCACTCTAAACCAAGCAAAAAGCGCTTTAGATATGAATGCACCTAGCTGGAATTTAC
ATCAATTACAAGGTAATCTAGCTGGGCATTGGTCTATCAAGGTAAGTGGAAATTGGCGTTTAACTTTTAAAGTTCAAAAT
GGTCACGCTGAAGTCGTGGACTATCAAGATTATCATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT226074 WP_002892066.1 NZ_CP087706:4001727-4002101 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT226074 NZ_CP121769:1501878-1502150 [Glaesserella parasuis]
ATGAAAATGTACAATCCAGCTCACCCAGGGCTTATTTTAAGAGAATATATTGAAGGATATAATGTCACAGAAGTGGCTAA
ACGTTTAGGTGTCACTCGTGTCACGCTTTCTCGTATTTTAAATGGCAAAGCTGCAATTTCACCTGAAATGGCTCTTAGAT
TAAGCCAATTATTAAAAACTAGCCCAGAATTATGGCTTGGTTTACAATCCCAATACGATCTTTGGCAGCTTGAACAACGC
CCAAGTTTTAATATTCAGCCGTTATTTGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References