Detailed information of TA system TA226072

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2598131..2599719
• Replicon: chromosome
• Accession: NZ_CP087706
• Organism: Klebsiella pneumoniae strain YZH2487

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486KW17
• Locus tag: LO768_RS12785
• Protein ID: WP_004190166.1
• Coordinates: 2598131..2599453 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: LO768_RS12790
• Protein ID: WP_002904790.1
• Coordinates: 2599453..2599719 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO768_RS12770 (2593187)	2593187..2595688	+	2502	WP_114263676.1	fimbria/pilus outer membrane usher protein	-
LO768_RS12775 (2595676)	2595676..2596680	+	1005	WP_004190163.1	fimbrial protein	-
LO768_RS12780 (2596822)	2596822..2598114	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LO768_RS12785 (2598131)	2598131..2599453	-	1323	WP_004190166.1	type II toxin-antitoxin system HipA family toxin	Toxin
LO768_RS12790 (2599453)	2599453..2599719	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LO768_RS12795 (2599984)	2599984..2600310	-	327	WP_004143476.1	hydroxyisourate hydrolase	-
LO768_RS12800 (2600307)	2600307..2600807	-	501	WP_004190169.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LO768_RS12805 (2600785)	2600785..2602164	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
LO768_RS12810 (2602510)	2602510..2603664	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LO768_RS12815 (2603645)	2603645..2604568	-	924	WP_004190172.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49171.46 Da
• Isoelectric Point: 7.5357

>T226072 WP_004190166.1 NZ_CP087706:c2599453-2598131 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T226072 NZ_CP121769:1208554-1208898 [Glaesserella parasuis]
ATGGAAACAGAAGAATATCTTACTTTTATTGAAACCAAAGTTTTTGAAGAAGACCGAAAAGCATTAATGTCTGATGATGA
ATATCAGAAATTTCAGGCTTATTTATTAGAATCTCACGAATTAGGCGATTTTATTCAGAATACTGGTGGTTGCCAAAAAA
TTCGCTGGAAACTAGAAAGTAATAACAAGGGCAAAAGTGGTGGTGTAAGGGTGATTTACTATGTTGTAACCAAACAGGGA
AAATTATTATTAATGATGATGTATGCTAAAAGCAAACAAGACAATATGAGTGATAAACAAAAAGCAATGTTAAAAGCGGT
TGTATCCCAATTAAGTGAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT226072 WP_002904790.1 NZ_CP087706:c2599719-2599453 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT226072 NZ_CP121769:1208901-1209197 [Glaesserella parasuis]
ATGGAAAAAGAACTTTTTGAACGTCTAATGGAAAGTGCGAGAGAAATGGTCGCCATTGAAAAAGGCGAAATAGAAGTACC
ACCGCATCGTATTCATATCCATAAAATCCCGAATGTCAAAGCGATTAGGACCCAGCACCAGATGAAACAAGCGGAATTTG
CTTCTCTTTTAGGCGTAAGCCAAAATCTTGTGCAGTCGTGGGAAATCGGCAGACGAACCCCAAATGGTGCGGCACGGAAA
TTGCTTGCGATTATTGAGCAACAGCCAGAACTTATCCCTGTATTACAAGGGATTTAA

Structures

Toxin

• AlphaFold DB: A0A486KW17

Antitoxin

• AlphaFold DB: A0A0H3GXD8