Detailed information of TA system TA022607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 4806444..4807038
• Replicon: chromosome
• Accession: NC_010170
• Organism: Bordetella petrii DSM 12804

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: BPET_RS23050
• Protein ID: WP_041863196.1
• Coordinates: 4806444..4806749 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: BPET_RS23055
• Protein ID: WP_012251376.1
• Coordinates: 4806730..4807038 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPET_RS23030	4801785..4802867	-	1083	WP_012251371.1	peptide chain release factor 1	-
BPET_RS23035	4802961..4804235	-	1275	WP_012251372.1	glutamyl-tRNA reductase	-
BPET_RS23045	4804647..4806005	+	1359	WP_012251373.1	integrase arm-type DNA-binding domain-containing protein	-
BPET_RS26225	4805980..4806240	-	261	WP_012251374.1	AlpA family phage regulatory protein	-
BPET_RS23050	4806444..4806749	+	306	WP_041863196.1	BrnT family toxin	Toxin
BPET_RS23055	4806730..4807038	+	309	WP_012251376.1	BrnA antitoxin family protein	Antitoxin
BPET_RS23060	4807704..4808117	+	414	WP_012251377.1	antirestriction protein	-
BPET_RS23065	4808163..4808870	-	708	WP_151208989.1	arsenical resistance protein ArsH	-
BPET_RS23070	4808881..4809303	-	423	WP_012251379.1	arsenate reductase (glutaredoxin)	-
BPET_RS23075	4809316..4810398	-	1083	WP_012251380.1	ACR3 family arsenite efflux transporter	-
BPET_RS23080	4810406..4810903	-	498	WP_012251381.1	arsenate reductase ArsC	-
BPET_RS23085	4810908..4811231	-	324	WP_041863198.1	helix-turn-helix domain-containing protein	-
BPET_RS26230	4811580..4811972	+	393	WP_081483037.1	ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-92)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (41-96)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11714.42 Da
• Isoelectric Point: 8.6212

>T22607 WP_041863196.1 NC_010170:4806444-4806749 [Bordetella petrii]
MFTQFEWDAAKAGANLRKHGVSFEVAMRVFADPLALTGLDRVERGEQRWQTLGMVDGYLLLLVAHTVLELNADNQSIEVI
RIISARRADRKERRRYEQEIR

Nucleotide

• Length: 306 bp

>T22607 NC_010170:4806444-4806749 [Bordetella petrii]
ATGTTCACGCAGTTTGAATGGGATGCTGCCAAGGCGGGAGCCAACCTACGTAAACACGGTGTGAGCTTCGAGGTCGCGAT
GCGGGTGTTTGCCGACCCTTTGGCGTTAACTGGGCTGGATCGCGTGGAACGAGGCGAGCAACGCTGGCAGACGCTTGGCA
TGGTGGATGGGTATCTCCTGCTTCTGGTGGCTCATACCGTTCTTGAACTGAACGCGGACAATCAATCCATTGAAGTTATC
CGCATCATCTCGGCCAGACGGGCCGACAGGAAAGAAAGGCGACGTTATGAGCAAGAAATCCGTTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11509.17 Da
• Isoelectric Point: 10.2147

>AT22607 WP_012251376.1 NC_010170:4806730-4807038 [Bordetella petrii]
MSKKSVKHEVNLANLPPLSDKQKAELAALSTRADEDVDYGDIPPLTAEFWKTAERGKFYKPTKTSTTVRIDSDVLAWLRS
QGKGYQSRINAILRREMLSSLK

Nucleotide

• Length: 309 bp

>AT22607 NC_010170:4806730-4807038 [Bordetella petrii]
ATGAGCAAGAAATCCGTTAAACATGAGGTAAATCTGGCTAACCTGCCTCCCCTTAGCGACAAACAGAAAGCCGAACTGGC
CGCGCTGTCGACGCGCGCTGATGAGGATGTCGATTACGGCGACATCCCTCCGTTGACGGCGGAGTTCTGGAAGACCGCTG
AACGCGGCAAGTTCTATAAGCCGACCAAGACGTCCACCACCGTACGCATTGATTCAGATGTCCTAGCATGGTTGCGGTCG
CAAGGCAAAGGCTATCAGTCTCGCATCAATGCGATTCTGCGACGGGAAATGCTGTCATCACTAAAGTAA