Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834270..834927 Replicon chromosome
Accession NZ_CP087706
Organism Klebsiella pneumoniae strain YZH2487

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LO768_RS04185 Protein ID WP_002916310.1
Coordinates 834517..834927 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LO768_RS04180 Protein ID WP_002916312.1
Coordinates 834270..834536 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO768_RS04155 (829426) 829426..830859 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LO768_RS04160 (830978) 830978..831706 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LO768_RS04165 (831756) 831756..832067 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LO768_RS04170 (832231) 832231..832890 + 660 WP_002916317.1 hemolysin III family protein -
LO768_RS04175 (833041) 833041..834024 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LO768_RS04180 (834270) 834270..834536 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LO768_RS04185 (834517) 834517..834927 + 411 WP_002916310.1 protein YgfX Toxin
LO768_RS04190 (834934) 834934..835455 - 522 WP_002916308.1 flavodoxin FldB -
LO768_RS04195 (835556) 835556..836452 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LO768_RS04200 (836475) 836475..837188 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LO768_RS04205 (837194) 837194..838927 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T226063 WP_002916310.1 NZ_CP087706:834517-834927 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T226063 NZ_CP121768:c594593-594249 [Glaesserella parasuis]
ATGACTACTCAAGAGTATATCCCTGACGTTGGTGATATTATTTGGCTTGATTTTGATCCGCAAGCAGGACATGAACAAGC
TGGTCATCGTCCAGCATTAGTGTTAACGCCCGCGATTTATAATCGTCAAACAGGGTTGTTAATTTGTTGCCCGCTCACAA
CAAAAGTAAAAGGCTATCCTTTCGAAGTCAATATTGCAGGTACCCCCCAAAATGTTGTGCTTTCCGATCAAATTAAAAGC
CTTGACTGGCGTATTCGTCACGCTAAATTTAAAGGTAAAATTAACCATCATCAGTTAAGCGAAGTAAAAGCTAAAATTGC
GACTTTGCTACAAATCAGTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT226063 WP_002916312.1 NZ_CP087706:834270-834536 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT226063 NZ_CP121768:c594829-594590 [Glaesserella parasuis]
ATGCAAGTGGCTGTCAAAAAATGGGGAAATAGCGTAGGCATTCGCATTCCTGCTTTATTATCTAATTCATTGAAATTACA
GGCAGAGAGTTTAGTCGATATTCAAGAAGTTGATGGTCGCCTAATTATTGAGCCGATTAAACCTAAATATAATTTAGAGC
AACTTCTTTCAGGTATTACTGAAGATAATTTGCACAATGAAGTCGATTTTGGCAAGCCTGTTGGCAAGGAAATGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References