Detailed information of TA system TA226057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 937..1487
• Replicon: plasmid pPLS16B
• Accession: NZ_CP087697
• Organism: Xylella taiwanensis strain PLS16B

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LPH57_RS11965
• Protein ID: WP_230428324.1
• Coordinates: 1197..1487 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LPH57_RS11960
• Protein ID: WP_230428323.1
• Coordinates: 937..1209 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH57_RS11955 (LPH57_11955)	2..802	+	801	WP_230428322.1	replication initiation protein	-
LPH57_RS11960 (LPH57_11960)	937..1209	+	273	WP_230428323.1	CopG family ribbon-helix-helix protein	Antitoxin
LPH57_RS11965 (LPH57_11965)	1197..1487	+	291	WP_230428324.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH57_RS11970 (LPH57_11970)	1550..1810	+	261	WP_230428325.1	hypothetical protein	-
LPH57_RS11975 (LPH57_11975)	1871..2041	+	171	WP_230428326.1	hypothetical protein	-
LPH57_RS11980 (LPH57_11980)	2050..2550	+	501	WP_230428327.1	hypothetical protein	-
LPH57_RS11985 (LPH57_11985)	2550..2858	+	309	WP_230428328.1	TrbC/VirB2 family protein	-
LPH57_RS11990 (LPH57_11990)	2863..3246	+	384	WP_230428329.1	VirB3 family type IV secretion system protein	-
LPH57_RS11995 (LPH57_11995)	3209..5623	+	2415	WP_230428330.1	transporter	-
LPH57_RS12000 (LPH57_12000)	5626..6291	+	666	WP_230428331.1	type IV secretion system protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..32575	32575

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10949.64 Da
• Isoelectric Point: 10.2328

>T226057 WP_230428324.1 NZ_CP087697:1197-1487 [Xylella taiwanensis]
VPRVIWTPPALNDVQRLYRFLAPKDANVARRAVQAIRVGVKVLAHQPRVGRPVDAMDLEFREWLIDFGNSGYVVFYRFDG
ETAAILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T226057 NZ_CP121766:c5173677-5173399 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGGCTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCAGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAACGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10628.87 Da
• Isoelectric Point: 5.1990

>AT226057 WP_230428323.1 NZ_CP087697:937-1209 [Xylella taiwanensis]
MATTIKLNDELRTRIQRLAGLRDRSAHWIMREAITQYVEREEKCDAFRQDAMRAWNEYQANGLHVTHEEADAWFAKLEAS
EDVEPPKCHE

Nucleotide

• Length: 273 bp

>AT226057 NZ_CP121766:c5173387-5173082 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG