Detailed information of TA system TA226051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 30653..31338
• Replicon: chromosome
• Accession: NZ_CP087696
• Organism: Xylella taiwanensis strain PLS16B

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LPH57_RS00150
• Protein ID: WP_200866210.1
• Coordinates: 30653..31057 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LPH57_RS00155
• Protein ID: WP_038272460.1
• Coordinates: 31066..31338 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH57_RS00125 (LPH57_00125)	26007..27218	-	1212	WP_038272508.1	signal recognition particle-docking protein FtsY	-
LPH57_RS00130 (LPH57_00130)	28063..28536	+	474	WP_038272510.1	LEA type 2 family protein	-
LPH57_RS00135 (LPH57_00135)	28812..29426	+	615	WP_081755477.1	HNH endonuclease	-
LPH57_RS00140 (LPH57_00140)	30010..30255	+	246	WP_230428284.1	hypothetical protein	-
LPH57_RS00145 (LPH57_00145)	30246..30590	+	345	WP_038272464.1	DUF3653 domain-containing protein	-
LPH57_RS00150 (LPH57_00150)	30653..31057	-	405	WP_200866210.1	type II toxin-antitoxin system VapC family toxin	Toxin
LPH57_RS00155 (LPH57_00155)	31066..31338	-	273	WP_038272460.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LPH57_RS00160 (LPH57_00160)	31428..32555	-	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH57_RS00165 (LPH57_00165)	32568..32912	-	345	WP_038273069.1	DUF2523 family protein	-
LPH57_RS00170 (LPH57_00170)	32915..34300	-	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH57_RS00175 (LPH57_00175)	34480..34716	-	237	WP_230428212.1	major capsid protein	-
LPH57_RS00180 (LPH57_00180)	34725..34931	-	207	WP_038273075.1	hypothetical protein	-
LPH57_RS00185 (LPH57_00185)	34934..35248	-	315	WP_230428211.1	hypothetical protein	-
LPH57_RS00190 (LPH57_00190)	35524..36111	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	28063..54115	26052

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-120)

Antitoxin

• SpoVT-AbrB domain (16-52)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14775.44 Da
• Isoelectric Point: 6.9054

>T226051 WP_200866210.1 NZ_CP087696:c31057-30653 [Xylella taiwanensis]
MLDTNIISDMIRNPFGLVACRIEKVDPKEVCTSIVVAAELRYGCAKKGSTKLLAKVKLMLETIPVLPLDIPTDAEYGRIR
AELESVGQTIGLNDLLIGTHAYVLGMTLVTDNVKEFKRIRGLKIENWLECASSV

Nucleotide

• Length: 405 bp

>T226051 NZ_CP121766:886914-887783 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACATCCCCGCCCCGAGCCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGCTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCACGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTACGTCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCTGCGCCTG
GAGAACCTGGAGCGCCTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCTGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGCCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATTGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10331.95 Da
• Isoelectric Point: 4.5216

>AT226051 WP_038272460.1 NZ_CP087696:c31338-31066 [Xylella taiwanensis]
MSISMPSSRLKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPVSMPTNIIELLAQWKTEDPLGLEDQFPEIE
DMLAKPDDIF

Nucleotide

• Length: 273 bp

>AT226051 NZ_CP121766:887776-888609 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTCTCGCCGTCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGCACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA