Detailed information of TA system TA226050

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-relB/-
• Location: 2373689..2374083
• Replicon: chromosome
• Accession: NZ_CP087695
• Organism: Xylella taiwanensis strain PLS434

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: LPH63_RS10185
• Protein ID: WP_200866186.1
• Coordinates: 2373880..2374083 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Z9JJI0
• Locus tag: LPH63_RS10180
• Protein ID: WP_038270756.1
• Coordinates: 2373689..2373883 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH63_RS10150 (LPH63_10150)	2369519..2370356	-	838	Protein_2007	VirB8/TrbF family protein	-
LPH63_RS10155 (LPH63_10155)	2370532..2371661	+	1130	Protein_2008	DUF5710 domain-containing protein	-
LPH63_RS10160 (LPH63_10160)	2371931..2372212	-	282	WP_038270748.1	XRE family transcriptional regulator	-
LPH63_RS10165 (LPH63_10165)	2372324..2372407	-	84	Protein_2010	type II toxin-antitoxin system RelE/ParE family toxin	-
LPH63_RS10170 (LPH63_10170)	2372541..2372921	-	381	WP_038270750.1	hypothetical protein	-
LPH63_RS10175 (LPH63_10175)	2373050..2373493	-	444	Protein_2012	DUF4158 domain-containing protein	-
LPH63_RS10180 (LPH63_10180)	2373689..2373883	+	195	WP_038270756.1	hypothetical protein	Antitoxin
LPH63_RS10185 (LPH63_10185)	2373880..2374083	+	204	WP_200866186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH63_RS10190 (LPH63_10190)	2374170..2374832	+	663	WP_268746643.1	recombinase family protein	-
LPH63_RS10195 (LPH63_10195)	2374905..2376296	-	1392	WP_051482280.1	right-handed parallel beta-helix repeat-containing protein	-
LPH63_RS10200 (LPH63_10200)	2377532..2378542	+	1011	WP_038270757.1	serine protease	-
LPH63_RS10205 (LPH63_10205)	2378929..2379069	-	141	WP_160165149.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-61)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7625.95 Da
• Isoelectric Point: 11.2308

>T226050 WP_200866186.1 NZ_CP087695:2373880-2374083 [Xylella taiwanensis]
MTLPLHWRTSARDDLASLIRFIAYENPLTARRMKVLIEASVLLASAHPYMFRPGRVPGTREIVAHPN

Nucleotide

• Length: 204 bp

>T226050 NZ_CP121764:81483-81839 [Prescottella equi]
GTGACGAACTGGGATGTGGACCTCGAGCTGATCGAAGACTGGCTGACCGAGCTGGATCAGGAGTCGTACGAACAGGTCGT
CGCCGCACTCGAGTTGCTCCAGGAGCGCGGCCCGCAGTTGGGTCGCCCCCTGGTCGACACCATCAAGGCGTCGCGCCACA
AGAACATGAAGGAGCTGCGACCAGGGTCCAGCGGCCGCTCGGAACTGCGGGTGTTGTTCGCGTTCGACCCGGAGCGGAAG
GCGATCTTCCTCGTCGCAGGCGACAAAGCTGGACGGTGGGAGAAGTGGTACAAGGTGAACATCCCCATCGCCGATGACCG
CTTCGACGACCATCTGCGCCAACTGGAAGGGAAGTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7289.11 Da
• Isoelectric Point: 4.5007

>AT226050 WP_038270756.1 NZ_CP087695:2373689-2373883 [Xylella taiwanensis]
MKTTPLDPIISEFATEEQAASYDRWFRAKVQASLDDSRPSVPHDQVMAEMDAIIAEAEQHRKQT

Nucleotide

• Length: 195 bp

>AT226050 NZ_CP121764:81845-82150 [Prescottella equi]
ATGGCAAAGAGTCTTGACGACATGCTGGCCAAGCGGCCCGTCGACCGGGCCGCAGTCGACACACACAAGGCCCGGATGCT
CGAACAGGTCCGCGCATACCGACTGCAGGAACTGCGCGAGGCACGCGAGCTGACGCAGCAGCAAGTGGCCGACCGCCTGG
GCGTGAAGCAGAACCGTGTCTCGAACATCGAGCGTGGTGACCTGGCGAACGTTCAGCTCGACACCCTGCGCCGCTACGTC
GACGCTGTGGGGGGCACGCTACGAATCGAAGTCGAACTCGGCGACGACCGAATCCAGATCGCCTAG

Structures

Antitoxin

• AlphaFold DB: Z9JJI0