Detailed information of TA system TA226048

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1567379..1567965
• Replicon: chromosome
• Accession: NZ_CP087695
• Organism: Xylella taiwanensis strain PLS434

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH63_RS06545
• Protein ID: WP_038273324.1
• Coordinates: 1567379..1567633 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH63_RS06550
• Protein ID: WP_038273322.1
• Coordinates: 1567630..1567965 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH63_RS06515 (LPH63_06515)	1562480..1563364	-	885	WP_114867111.1	hypothetical protein	-
LPH63_RS06520 (LPH63_06520)	1563379..1564725	-	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH63_RS06525 (LPH63_06525)	1564801..1565151	+	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH63_RS06530 (LPH63_06530)	1565153..1565425	-	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH63_RS06535 (LPH63_06535)	1565429..1566622	-	1194	WP_230428203.1	hypothetical protein	-
LPH63_RS06540 (LPH63_06540)	1566579..1567277	+	699	WP_114867108.1	hypothetical protein	-
LPH63_RS06545 (LPH63_06545)	1567379..1567633	+	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH63_RS06550 (LPH63_06550)	1567630..1567965	+	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH63_RS06555 (LPH63_06555)	1568218..1568619	+	402	WP_114867107.1	lysozyme	-
LPH63_RS06560 (LPH63_06560)	1568640..1569722	+	1083	WP_051482382.1	phage terminase large subunit	-
LPH63_RS06565 (LPH63_06565)	1569719..1570435	+	717	WP_160165226.1	portal protein	-
LPH63_RS06570 (LPH63_06570)	1570507..1570827	+	321	WP_038272832.1	hypothetical protein	-
LPH63_RS06575 (LPH63_06575)	1571329..1572537	-	1209	WP_038272829.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1554524..1572537	18013

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T226048 WP_038273324.1 NZ_CP087695:1567379-1567633 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T226048 NZ_CP121700:c5450985-5450692 [Methylobacterium indicum]
ATGATCCGGATCAGGCAGACAGCGACCTTCCGTCGATGGGAGCAGCAGCTCAAGGATCAACGAGCCCGCACGGTGATCGC
GGCCCGGTTGCTGCGGCTCGCAAACGGTCTCGTCGGCGACGCCGCCCCCGTCGGCAGAGGCGTCAGCGAGCTTCGCATCC
ATTACGGCCCTGGTTACCGCATTTATTTTCAACGGCGGGGCGACGACATCGTGATTTTGCTGTGTGGGGGTGACAAAGCG
AGCCAGGATCGCGACATCCAGAAGGCTTTGCAACTCGCTGAAGAAGAGGGCTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT226048 WP_038273322.1 NZ_CP087695:1567630-1567965 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT226048 NZ_CP121700:c5450689-5450408 [Methylobacterium indicum]
ATGGCCGAGGAGATCACCGATTTCGATTTTGCCGCGTCGCTTCAATCCGACGAGGCGATCGCGATCTTTCTCTCGGACGC
CTTTGAGACCGGTGACGCGAACCATATCGCGGCGGCTCTCGAGATTGCCATCCGCGCCAAGGGCGAGGCCCGGATCGCTT
CAAGGGCGGAAATCCCGGAGAACGGATACGATCTGGACAACCCGACCCTCGCGACGATGCTCGCCGTGATGAAGGCTCTT
GGGGTCGGTTTCTCGCCCATGCCCGTTCGCGCAGCGTCGTGA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5