Detailed information of TA system TA226047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1376575..1377260
• Replicon: chromosome
• Accession: NZ_CP087695
• Organism: Xylella taiwanensis strain PLS434

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LPH63_RS05605
• Protein ID: WP_038272463.1
• Coordinates: 1376844..1377260 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LPH63_RS05600
• Protein ID: WP_038272460.1
• Coordinates: 1376575..1376847 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH63_RS05565 (LPH63_05565)	1371802..1372389	+	588	WP_038273076.1	hypothetical protein	-
LPH63_RS05570 (LPH63_05570)	1372665..1372979	+	315	WP_230428211.1	hypothetical protein	-
LPH63_RS05575 (LPH63_05575)	1372982..1373188	+	207	WP_038273075.1	hypothetical protein	-
LPH63_RS05580 (LPH63_05580)	1373197..1373433	+	237	WP_230428212.1	major capsid protein	-
LPH63_RS05585 (LPH63_05585)	1373613..1374998	+	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH63_RS05590 (LPH63_05590)	1375001..1375345	+	345	WP_038273069.1	DUF2523 family protein	-
LPH63_RS05595 (LPH63_05595)	1375358..1376485	+	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH63_RS05600 (LPH63_05600)	1376575..1376847	+	273	WP_038272460.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LPH63_RS05605 (LPH63_05605)	1376844..1377260	+	417	WP_038272463.1	type II toxin-antitoxin system VapC family toxin	Toxin
LPH63_RS05610 (LPH63_05610)	1377323..1377667	-	345	WP_038272464.1	DUF3653 domain-containing protein	-
LPH63_RS05615 (LPH63_05615)	1377658..1377990	-	333	WP_268980386.1	DUF3693 domain-containing protein	-
LPH63_RS05620 (LPH63_05620)	1378487..1379101	-	615	WP_081755477.1	HNH endonuclease	-
LPH63_RS05625 (LPH63_05625)	1379377..1379850	-	474	WP_038272510.1	LEA type 2 family protein	-
LPH63_RS05630 (LPH63_05630)	1380695..1381906	+	1212	WP_038272508.1	signal recognition particle-docking protein FtsY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1353797..1379149	25352

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-52)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15195.91 Da
• Isoelectric Point: 6.9048

>T226047 WP_038272463.1 NZ_CP087695:1376844-1377260 [Xylella taiwanensis]
MSGYLLDTNIISDMIRNPFGLVACRIEKVDPKEVCTSIVVAAELRYGCAKKGSTKLLAKVKLMLETIPVLPLDIPTDAEY
GRIRAELESVGQTIGLNDLLIGTHAYVLGMTLVTDNVKEFKRIRGLKIENWLECASSV

Nucleotide

• Length: 417 bp

>T226047 NZ_CP121700:c5450689-5450408 [Methylobacterium indicum]
ATGGCCGAGGAGATCACCGATTTCGATTTTGCCGCGTCGCTTCAATCCGACGAGGCGATCGCGATCTTTCTCTCGGACGC
CTTTGAGACCGGTGACGCGAACCATATCGCGGCGGCTCTCGAGATTGCCATCCGCGCCAAGGGCGAGGCCCGGATCGCTT
CAAGGGCGGAAATCCCGGAGAACGGATACGATCTGGACAACCCGACCCTCGCGACGATGCTCGCCGTGATGAAGGCTCTT
GGGGTCGGTTTCTCGCCCATGCCCGTTCGCGCAGCGTCGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10331.95 Da
• Isoelectric Point: 4.5216

>AT226047 WP_038272460.1 NZ_CP087695:1376575-1376847 [Xylella taiwanensis]
MSISMPSSRLKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPVSMPTNIIELLAQWKTEDPLGLEDQFPEIE
DMLAKPDDIF

Nucleotide

• Length: 273 bp

>AT226047 NZ_CP121700:c5450985-5450692 [Methylobacterium indicum]
ATGATCCGGATCAGGCAGACAGCGACCTTCCGTCGATGGGAGCAGCAGCTCAAGGATCAACGAGCCCGCACGGTGATCGC
GGCCCGGTTGCTGCGGCTCGCAAACGGTCTCGTCGGCGACGCCGCCCCCGTCGGCAGAGGCGTCAGCGAGCTTCGCATCC
ATTACGGCCCTGGTTACCGCATTTATTTTCAACGGCGGGGCGACGACATCGTGATTTTGCTGTGTGGGGGTGACAAAGCG
AGCCAGGATCGCGACATCCAGAAGGCTTTGCAACTCGCTGAAGAAGAGGGCTGA