Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 1361032..1361573 | Replicon | chromosome |
| Accession | NZ_CP087695 | ||
| Organism | Xylella taiwanensis strain PLS434 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Z9JGT1 |
| Locus tag | LPH63_RS05450 | Protein ID | WP_038273166.1 |
| Coordinates | 1361032..1361355 (-) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | Z9JGL9 |
| Locus tag | LPH63_RS05455 | Protein ID | WP_038273164.1 |
| Coordinates | 1361352..1361573 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH63_RS05420 (LPH63_05420) | 1357174..1357467 | + | 294 | WP_038273093.1 | single-stranded DNA-binding protein | - |
| LPH63_RS05425 (LPH63_05425) | 1357467..1357676 | + | 210 | WP_230428208.1 | hypothetical protein | - |
| LPH63_RS05430 (LPH63_05430) | 1357685..1357903 | + | 219 | WP_051482398.1 | major capsid protein | - |
| LPH63_RS05435 (LPH63_05435) | 1358371..1359438 | + | 1068 | WP_152536670.1 | virulence factor TspB C-terminal domain-related protein | - |
| LPH63_RS05440 (LPH63_05440) | 1359442..1359783 | + | 342 | WP_038273089.1 | DUF2523 family protein | - |
| LPH63_RS05445 (LPH63_05445) | 1359783..1360931 | + | 1149 | WP_069636227.1 | zonular occludens toxin domain-containing protein | - |
| LPH63_RS05450 (LPH63_05450) | 1361032..1361355 | - | 324 | WP_038273166.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LPH63_RS05455 (LPH63_05455) | 1361352..1361573 | - | 222 | WP_038273164.1 | antitoxin MazE family protein | Antitoxin |
| LPH63_RS05460 (LPH63_05460) | 1362021..1362827 | + | 807 | WP_230439338.1 | site-specific integrase | - |
| LPH63_RS05465 (LPH63_05465) | 1362790..1362939 | - | 150 | Protein_1086 | DUF3693 domain-containing protein | - |
| LPH63_RS05470 (LPH63_05470) | 1363229..1363390 | + | 162 | WP_160165236.1 | hypothetical protein | - |
| LPH63_RS05475 (LPH63_05475) | 1363394..1363657 | + | 264 | WP_162814095.1 | hypothetical protein | - |
| LPH63_RS05480 (LPH63_05480) | 1363706..1363906 | + | 201 | WP_038273077.1 | hypothetical protein | - |
| LPH63_RS05485 (LPH63_05485) | 1364026..1364169 | + | 144 | WP_160165233.1 | hypothetical protein | - |
| LPH63_RS05490 (LPH63_05490) | 1364366..1364953 | + | 588 | WP_038273076.1 | hypothetical protein | - |
| LPH63_RS05495 (LPH63_05495) | 1365229..1365543 | + | 315 | WP_230428211.1 | hypothetical protein | - |
| LPH63_RS05500 (LPH63_05500) | 1365546..1365752 | + | 207 | WP_038273075.1 | hypothetical protein | - |
| LPH63_RS05505 (LPH63_05505) | 1365761..1365997 | + | 237 | WP_230428212.1 | major capsid protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1353797..1379149 | 25352 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 11807.97 Da Isoelectric Point: 9.1188
>T226045 WP_038273166.1 NZ_CP087695:c1361355-1361032 [Xylella taiwanensis]
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
Download Length: 324 bp
>T226045 NZ_CP121700:4129509-4129790 [Methylobacterium indicum]
GTGATCCGCAGCTTCGCCGATGAGCGGACCCGCCACGTCTTTGAGGGACGGCATCCGAAGGGTATCCCGGCCGACATTCT
CAAGACGGCCCGGCGCAAGCTCGACTATCTGGACGCGGCAACCTCGCTCGACGCCCTGAAGGTTCCGCCGGGCAACAAGC
TGCATCCGCTGCTCCGCGCGCGCGCCGGGCAACACGCCATCCGGATCAACGATCAGTTCCGCGTGTGCTTTCGCTGGACG
GAAATCGGACCGGAGGACGTGGAGATCGTCGACTATCACTGA
GTGATCCGCAGCTTCGCCGATGAGCGGACCCGCCACGTCTTTGAGGGACGGCATCCGAAGGGTATCCCGGCCGACATTCT
CAAGACGGCCCGGCGCAAGCTCGACTATCTGGACGCGGCAACCTCGCTCGACGCCCTGAAGGTTCCGCCGGGCAACAAGC
TGCATCCGCTGCTCCGCGCGCGCGCCGGGCAACACGCCATCCGGATCAACGATCAGTTCCGCGTGTGCTTTCGCTGGACG
GAAATCGGACCGGAGGACGTGGAGATCGTCGACTATCACTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8490.65 Da Isoelectric Point: 8.0827
>AT226045 WP_038273164.1 NZ_CP087695:c1361573-1361352 [Xylella taiwanensis]
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
Download Length: 222 bp
>AT226045 NZ_CP121700:4129837-4130157 [Methylobacterium indicum]
ATGAGCACCGAGTACGAGAGCGATACCGTCCTGCCGCCGATGCACCCGGGCGAGGTGCTGCGGGAAGAGTTCATGGTTCC
GCTGAACCTGACGGCCTACGCCATCGCGAAGGCGTGTCGCGTGCCGCGGACGCGGATCGAGCGCATCGCCCGCGAGGAGA
TCGGCATCACCGCCGATACCGCCCTGCGGCTCGGACGCTATTTCGGAATGGACCCGCAGGTCTGGGTGAACCTCCAGAGC
CGTTTCGACCTGCTGACCGCCCGCGCGGCGATCGGTGCGGCGATGGACGACATCCGCCCCCTGCAGCGAGAGGCGGCCTA
A
ATGAGCACCGAGTACGAGAGCGATACCGTCCTGCCGCCGATGCACCCGGGCGAGGTGCTGCGGGAAGAGTTCATGGTTCC
GCTGAACCTGACGGCCTACGCCATCGCGAAGGCGTGTCGCGTGCCGCGGACGCGGATCGAGCGCATCGCCCGCGAGGAGA
TCGGCATCACCGCCGATACCGCCCTGCGGCTCGGACGCTATTTCGGAATGGACCCGCAGGTCTGGGTGAACCTCCAGAGC
CGTTTCGACCTGCTGACCGCCCGCGCGGCGATCGGTGCGGCGATGGACGACATCCGCCCCCTGCAGCGAGAGGCGGCCTA
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|