Detailed information of TA system TA226044

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2664901..2665487
• Replicon: chromosome
• Accession: NZ_CP087694
• Organism: Xylella taiwanensis strain PLS433

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH46_RS11120
• Protein ID: WP_038273324.1
• Coordinates: 2665233..2665487 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH46_RS11115
• Protein ID: WP_038273322.1
• Coordinates: 2664901..2665236 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH46_RS11090 (LPH46_11090)	2660329..2661537	+	1209	WP_038272829.1	hypothetical protein	-
LPH46_RS11095 (LPH46_11095)	2662039..2662359	-	321	WP_038272832.1	hypothetical protein	-
LPH46_RS11100 (LPH46_11100)	2662431..2663147	-	717	WP_160165226.1	portal protein	-
LPH46_RS11105 (LPH46_11105)	2663144..2664250	-	1107	WP_114867106.1	phage terminase large subunit	-
LPH46_RS11110 (LPH46_11110)	2664247..2664648	-	402	WP_114867107.1	lysozyme	-
LPH46_RS11115 (LPH46_11115)	2664901..2665236	-	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH46_RS11120 (LPH46_11120)	2665233..2665487	-	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH46_RS11125 (LPH46_11125)	2665589..2666287	-	699	WP_114867108.1	hypothetical protein	-
LPH46_RS11130 (LPH46_11130)	2666244..2667437	+	1194	WP_230428203.1	hypothetical protein	-
LPH46_RS11135 (LPH46_11135)	2667441..2667713	+	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH46_RS11140 (LPH46_11140)	2667715..2668065	-	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH46_RS11145 (LPH46_11145)	2668141..2669487	+	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH46_RS11150 (LPH46_11150)	2669502..2670386	+	885	WP_114867111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2660329..2679412	19083

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T226044 WP_038273324.1 NZ_CP087694:c2665487-2665233 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T226044 NZ_CP121700:3865509-3865913 [Methylobacterium indicum]
ATGAGCGGCCCGCGCTTCCTGCTCGATACGAACATCCTCTCCGATCTGATCCGCAACCCGTCCGGTGCCGTGGCCCGGCA
GATCGCACGGGTCGGCAGCAAAGGCATCGCGACGAGCATCGTCTCGGTCGCGGAACTCCGCTACGGCTGCGCGAAGCGGG
GGTCGGCTCGCCTTCTTCGTCAGGTCGAAGCCGTGCTGGAAGCGATCGACGTGGTTCCGTTCGAGACTCCCGCCGATGTC
ATCTATGGAAGAATTCGCGCCGATCTCGAGGCTGCGGGTCGGCCGATCGGACCGAACGATCTCCTCATCGCGGCTCAGGC
GCTCGCGCTCGAGGTTCCGCTCGTGACGGCGAACGAGGCGGAGTTTCGGCGTGTCGGCGGGCTGACGGTCGAGAACTGGC
TCTAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT226044 WP_038273322.1 NZ_CP087694:c2665236-2664901 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT226044 NZ_CP121700:3865255-3865512 [Methylobacterium indicum]
ATGGCGAGACCGACCCCGATACCGCAGGCGCGGGAGGTGAAGCTGTTCCGCAACAATCGCAGCCAGGCCGTGCGCATCCC
GGCCGAATTCGCCTTGCCCGGGGACCGGGTCCGCATCAGCCGCGATGGCGACCGCCTCATCCTGGAGCCGATCGGCAAGA
AGGACCTTCTGGAGGTCCTGGCGACCCTGGAGCCGATCGAGGAGGATTTCCCGGACTTCGACGAGACGCTGCCGCCCCTG
GACGATGATCCGCTATGA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5