Detailed information of TA system TA226042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-relB/-
• Location: 1858735..1859129
• Replicon: chromosome
• Accession: NZ_CP087694
• Organism: Xylella taiwanensis strain PLS433

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: LPH46_RS07495
• Protein ID: WP_200866186.1
• Coordinates: 1858735..1858938 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Z9JJI0
• Locus tag: LPH46_RS07500
• Protein ID: WP_038270756.1
• Coordinates: 1858935..1859129 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH46_RS07475 (LPH46_07475)	1853749..1853889	+	141	WP_160165149.1	hypothetical protein	-
LPH46_RS07480 (LPH46_07480)	1854276..1855286	-	1011	WP_038270757.1	serine protease	-
LPH46_RS07485 (LPH46_07485)	1856522..1857913	+	1392	WP_051482280.1	right-handed parallel beta-helix repeat-containing protein	-
LPH46_RS07490 (LPH46_07490)	1857986..1858648	-	663	WP_268746643.1	recombinase family protein	-
LPH46_RS07495 (LPH46_07495)	1858735..1858938	-	204	WP_200866186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH46_RS07500 (LPH46_07500)	1858935..1859129	-	195	WP_038270756.1	hypothetical protein	Antitoxin
LPH46_RS07505 (LPH46_07505)	1859325..1859768	+	444	Protein_1480	DUF4158 domain-containing protein	-
LPH46_RS07510 (LPH46_07510)	1859897..1860277	+	381	WP_038270750.1	hypothetical protein	-
LPH46_RS07515 (LPH46_07515)	1860411..1860494	+	84	Protein_1482	type II toxin-antitoxin system RelE/ParE family toxin	-
LPH46_RS07520 (LPH46_07520)	1860606..1860887	+	282	WP_038270748.1	XRE family transcriptional regulator	-
LPH46_RS07525 (LPH46_07525)	1861157..1862286	-	1130	Protein_1484	DUF5710 domain-containing protein	-
LPH46_RS07530 (LPH46_07530)	1862462..1863299	+	838	Protein_1485	VirB8/TrbF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-61)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7625.95 Da
• Isoelectric Point: 11.2308

>T226042 WP_200866186.1 NZ_CP087694:c1858938-1858735 [Xylella taiwanensis]
MTLPLHWRTSARDDLASLIRFIAYENPLTARRMKVLIEASVLLASAHPYMFRPGRVPGTREIVAHPN

Nucleotide

• Length: 204 bp

>T226042 NZ_CP121700:300995-301204 [Methylobacterium indicum]
ATGGCTCCTAAACAGAGAAGCCGCAAAACCCGTGACGTGCTCGCGATGCTCGTGAAGGACGGATGGTTCGTCGCCCGCAA
GGGTCCCGGTGATCACGTCCAGTACAAGCACCCGACCAAGCCCGGAAAGGTTACGGTCGATAGCGGGGCGTCCGAGATCC
CGACCGGGACGCTTCATAACATCTACCGGCAAGCGGGATGGGAGTGGTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7289.11 Da
• Isoelectric Point: 4.5007

>AT226042 WP_038270756.1 NZ_CP087694:c1859129-1858935 [Xylella taiwanensis]
MKTTPLDPIISEFATEEQAASYDRWFRAKVQASLDDSRPSVPHDQVMAEMDAIIAEAEQHRKQT

Nucleotide

• Length: 195 bp

>AT226042 NZ_CP121700:301241-301645 [Methylobacterium indicum]
ATGGTCCGCATCGTCATGCTGGTTCACGAAGAAGAGGGAGTCTTCGGCGCCTCGTTCCCGGATTTTCCAGGTGCAACGAC
CGTCGCCGACGATCTCGACACGCTCTATCGCAAGGCGGCCGAGATGCTCGCCTTCCACGTCAACGGCATGGCCGAGGACG
GCGACGCTATTCCGGCCCTGCGCACCCTGAGCGAGTTGCAGCAGGATCCGGTGTTCCGGGACGACAGCGAGGGCGCCATG
ATCGGTCTCGTCGACGTCGATCTGCCCGGCAAGGCGGTGCGGGTGAACGTCTCCATCGAGGAAGGCCTCCTCAAGCGGAT
CGACCACGCGGCGGCGGCCGCCGGCGAGAGCCGGTCGAGTTTCCTCGCCCGGGCGGCCCGGGCTCGCCTGTCGACAGCCG
CCTGA

Structures

Antitoxin

• AlphaFold DB: Z9JJI0