Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 46366..46907 | Replicon | chromosome |
| Accession | NZ_CP087694 | ||
| Organism | Xylella taiwanensis strain PLS433 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Z9JGT1 |
| Locus tag | LPH46_RS00300 | Protein ID | WP_038273166.1 |
| Coordinates | 46584..46907 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | Z9JGL9 |
| Locus tag | LPH46_RS00295 | Protein ID | WP_038273164.1 |
| Coordinates | 46366..46587 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH46_RS00245 (LPH46_00245) | 41942..42178 | - | 237 | WP_230428212.1 | major capsid protein | - |
| LPH46_RS00250 (LPH46_00250) | 42187..42393 | - | 207 | WP_038273075.1 | hypothetical protein | - |
| LPH46_RS00255 (LPH46_00255) | 42396..42710 | - | 315 | WP_230428211.1 | hypothetical protein | - |
| LPH46_RS00260 (LPH46_00260) | 42986..43573 | - | 588 | WP_038273076.1 | hypothetical protein | - |
| LPH46_RS00265 (LPH46_00265) | 43770..43913 | - | 144 | WP_160165233.1 | hypothetical protein | - |
| LPH46_RS00270 (LPH46_00270) | 44033..44233 | - | 201 | WP_038273077.1 | hypothetical protein | - |
| LPH46_RS00275 (LPH46_00275) | 44282..44545 | - | 264 | WP_162814095.1 | hypothetical protein | - |
| LPH46_RS00280 (LPH46_00280) | 44549..44710 | - | 162 | WP_160165236.1 | hypothetical protein | - |
| LPH46_RS00285 (LPH46_00285) | 45000..45329 | + | 330 | WP_230428286.1 | DUF3693 domain-containing protein | - |
| LPH46_RS00290 (LPH46_00290) | 45418..45918 | - | 501 | Protein_57 | tyrosine-type recombinase/integrase | - |
| LPH46_RS00295 (LPH46_00295) | 46366..46587 | + | 222 | WP_038273164.1 | antitoxin MazE family protein | Antitoxin |
| LPH46_RS00300 (LPH46_00300) | 46584..46907 | + | 324 | WP_038273166.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LPH46_RS00305 (LPH46_00305) | 47008..48156 | - | 1149 | WP_069636227.1 | zonular occludens toxin domain-containing protein | - |
| LPH46_RS00310 (LPH46_00310) | 48156..48497 | - | 342 | WP_038273089.1 | DUF2523 family protein | - |
| LPH46_RS00315 (LPH46_00315) | 48501..49568 | - | 1068 | WP_152536670.1 | virulence factor TspB C-terminal domain-related protein | - |
| LPH46_RS00320 (LPH46_00320) | 50036..50254 | - | 219 | WP_051482398.1 | major capsid protein | - |
| LPH46_RS00325 (LPH46_00325) | 50263..50472 | - | 210 | WP_230428208.1 | hypothetical protein | - |
| LPH46_RS00330 (LPH46_00330) | 50472..50765 | - | 294 | WP_038273093.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 35707..54142 | 18435 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 11807.97 Da Isoelectric Point: 9.1188
>T226041 WP_038273166.1 NZ_CP087694:46584-46907 [Xylella taiwanensis]
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
Download Length: 324 bp
>T226041 NZ_CP121698:c1360147-1359896 [Xanthomonas sacchari]
ATGGACACCATCACCTATAGCGCCGCACGTGCCGCTCTCGCGGACACCATGGACCGCGTGGTCAACAACCACGAGCCGGT
GATCATCACACGCAGCCGCGAGCAAGCCGTTGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAGGAAACCGCCTATC
TGCTGCGCAGCCCGAAGAACGCGCAGCGCTTGCTGGAATCCATCGCCCAACTCGAATCCGGTCGCGGCAAGGCGCGGGAA
CTGAGCGAGTGA
ATGGACACCATCACCTATAGCGCCGCACGTGCCGCTCTCGCGGACACCATGGACCGCGTGGTCAACAACCACGAGCCGGT
GATCATCACACGCAGCCGCGAGCAAGCCGTTGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAGGAAACCGCCTATC
TGCTGCGCAGCCCGAAGAACGCGCAGCGCTTGCTGGAATCCATCGCCCAACTCGAATCCGGTCGCGGCAAGGCGCGGGAA
CTGAGCGAGTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8490.65 Da Isoelectric Point: 8.0827
>AT226041 WP_038273164.1 NZ_CP087694:46366-46587 [Xylella taiwanensis]
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
Download Length: 222 bp
>AT226041 NZ_CP121698:c1359899-1359642 [Xanthomonas sacchari]
GTGACGCTGCAGTTCTCGGACAACGCCTGGGAGGATTATCTCTACTGGCAACAGGCCGACAAAAAGATGCTCAAGCGCAT
CAACGACCTGATCAAGGCCATTCAACGCGATCCCTTCCAGGGCATCGGCAAACCCGAACCGCTACGCCATGCACTTGCAG
GCTACTGGTCGCGACGCATCAACGACGAACACCGGATCGTCTACAAGGTCGAGCATGGCGTTCTGCTGATTGCACAAGTG
CGATATCACTACGTTTAA
GTGACGCTGCAGTTCTCGGACAACGCCTGGGAGGATTATCTCTACTGGCAACAGGCCGACAAAAAGATGCTCAAGCGCAT
CAACGACCTGATCAAGGCCATTCAACGCGATCCCTTCCAGGGCATCGGCAAACCCGAACCGCTACGCCATGCACTTGCAG
GCTACTGGTCGCGACGCATCAACGACGAACACCGGATCGTCTACAAGGTCGAGCATGGCGTTCTGCTGATTGCACAAGTG
CGATATCACTACGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|