Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2664963..2665549 Replicon chromosome
Accession NZ_CP087693
Organism Xylella taiwanensis strain PLS429

Toxin (Protein)


Gene name hicA Uniprot ID Z9JFU4
Locus tag LPH62_RS11100 Protein ID WP_038273324.1
Coordinates 2665295..2665549 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Z9JGM5
Locus tag LPH62_RS11095 Protein ID WP_038273322.1
Coordinates 2664963..2665298 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPH62_RS11070 (LPH62_11070) 2660391..2661599 + 1209 WP_038272829.1 hypothetical protein -
LPH62_RS11075 (LPH62_11075) 2662101..2662421 - 321 WP_038272832.1 hypothetical protein -
LPH62_RS11080 (LPH62_11080) 2662493..2663209 - 717 WP_160165226.1 portal protein -
LPH62_RS11085 (LPH62_11085) 2663206..2664312 - 1107 WP_114867106.1 phage terminase large subunit -
LPH62_RS11090 (LPH62_11090) 2664309..2664710 - 402 WP_114867107.1 lysozyme -
LPH62_RS11095 (LPH62_11095) 2664963..2665298 - 336 WP_038273322.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LPH62_RS11100 (LPH62_11100) 2665295..2665549 - 255 WP_038273324.1 type II toxin-antitoxin system HicA family toxin Toxin
LPH62_RS11105 (LPH62_11105) 2665651..2666349 - 699 WP_114867108.1 hypothetical protein -
LPH62_RS11110 (LPH62_11110) 2666306..2667499 + 1194 WP_230428203.1 hypothetical protein -
LPH62_RS11115 (LPH62_11115) 2667503..2667775 + 273 WP_114867070.1 VRR-NUC domain-containing protein -
LPH62_RS11120 (LPH62_11120) 2667777..2668127 - 351 WP_114867109.1 DUF1640 domain-containing protein -
LPH62_RS11125 (LPH62_11125) 2668203..2669549 + 1347 WP_114867110.1 DEAD/DEAH box helicase -
LPH62_RS11130 (LPH62_11130) 2669564..2670448 + 885 WP_114867111.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2660391..2679474 19083


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9561.95 Da        Isoelectric Point: 11.1842

>T226038 WP_038273324.1 NZ_CP087693:c2665549-2665295 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T226038 NZ_CP121698:510210-510362 [Xanthomonas sacchari]
ATGAAGCGACTGACCACCCTGTTGATGCTGACCCTGTTTTGCGCTGGTGTGCTGACCGGCTGCAACACCGTTGCCGGCGC
CGGCAAGGACATGCAGAAGGCGGGCGAGAAGGTGGAAGACACCGCCAAGGATTGCAGCGCGGGCAAGTGCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12318.98 Da        Isoelectric Point: 4.7313

>AT226038 WP_038273322.1 NZ_CP087693:c2665298-2664963 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Download         Length: 336 bp

>AT226038 NZ_CP121698:510418-510552 [Xanthomonas sacchari]
ATGAAGCGTACGTTTGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGGCCGGTTGCAACACCGTTGCCGGTGC
CGGCAAGGACGTGCAGAAGGCAGGCGAGAAGGTCCAAGACGCCGCCAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Z9JFU4

Antitoxin

Source ID Structure
AlphaFold DB Z9JGM5

References