Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 46441..46982 Replicon chromosome
Accession NZ_CP087693
Organism Xylella taiwanensis strain PLS429

Toxin (Protein)


Gene name mazF Uniprot ID Z9JGT1
Locus tag LPH62_RS00300 Protein ID WP_038273166.1
Coordinates 46659..46982 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Z9JGL9
Locus tag LPH62_RS00295 Protein ID WP_038273164.1
Coordinates 46441..46662 (+) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPH62_RS00245 (LPH62_00245) 42017..42253 - 237 WP_230428212.1 major capsid protein -
LPH62_RS00250 (LPH62_00250) 42262..42468 - 207 WP_038273075.1 hypothetical protein -
LPH62_RS00255 (LPH62_00255) 42471..42785 - 315 WP_230428211.1 hypothetical protein -
LPH62_RS00260 (LPH62_00260) 43061..43648 - 588 WP_038273076.1 hypothetical protein -
LPH62_RS00265 (LPH62_00265) 43845..43988 - 144 WP_160165233.1 hypothetical protein -
LPH62_RS00270 (LPH62_00270) 44108..44308 - 201 WP_038273077.1 hypothetical protein -
LPH62_RS00275 (LPH62_00275) 44357..44620 - 264 WP_162814095.1 hypothetical protein -
LPH62_RS00280 (LPH62_00280) 44624..44785 - 162 WP_160165236.1 hypothetical protein -
LPH62_RS00285 (LPH62_00285) 45075..45404 + 330 WP_230428286.1 DUF3693 domain-containing protein -
LPH62_RS00290 (LPH62_00290) 45493..45993 - 501 Protein_57 tyrosine-type recombinase/integrase -
LPH62_RS00295 (LPH62_00295) 46441..46662 + 222 WP_038273164.1 antitoxin MazE family protein Antitoxin
LPH62_RS00300 (LPH62_00300) 46659..46982 + 324 WP_038273166.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPH62_RS00305 (LPH62_00305) 47083..48231 - 1149 WP_069636227.1 zonular occludens toxin domain-containing protein -
LPH62_RS00310 (LPH62_00310) 48231..48572 - 342 WP_038273089.1 DUF2523 family protein -
LPH62_RS00315 (LPH62_00315) 48576..49643 - 1068 WP_152536670.1 virulence factor TspB C-terminal domain-related protein -
LPH62_RS00320 (LPH62_00320) 50111..50329 - 219 WP_051482398.1 major capsid protein -
LPH62_RS00325 (LPH62_00325) 50338..50547 - 210 WP_230428208.1 hypothetical protein -
LPH62_RS00330 (LPH62_00330) 50547..50840 - 294 WP_038273093.1 single-stranded DNA-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 35782..58350 22568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-105)

Antitoxin

(9-72)


Sequences


Toxin        


Download         Length: 108 a.a.        Molecular weight: 11807.97 Da        Isoelectric Point: 9.1188

>T226035 WP_038273166.1 NZ_CP087693:46659-46982 [Xylella taiwanensis]
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII

Download         Length: 324 bp

>T226035 NZ_CP121682:5278792-5279118 [Streptomyces sp. HUAS 5]
ATGGTGGACCTGGAACCGGCGAGGGGCAGCGAAGCCAATAAGGTGAGGCCGGCAGTGATTGTCTCCAACAACGCTGCCAA
CGAGTCTGTCGTGCAGCACAACCGGGGGGTCGTCACGGTGGTGCCGCTGACGTCCAACACCTCTCGCGTCCTGACGTTCC
AGGTCTTTCTGAGCTCTGACGAGAGCCGCCTGCCGAAGGACTCCAAGGTGCAGTGCGAGCAGGTACGTGCCGTTGCGCCG
GACCGCCTGCTGCACAAGGTCGGCGCCGTGCCGCGGCAGCGCATGGCCGAGATCGACGTGGCGCTGCGGCGGCATCTGGC
GCTGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8490.65 Da        Isoelectric Point: 8.0827

>AT226035 WP_038273164.1 NZ_CP087693:46441-46662 [Xylella taiwanensis]
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK

Download         Length: 222 bp

>AT226035 NZ_CP121682:5278554-5278784 [Streptomyces sp. HUAS 5]
ATGAAGATCAGTGTGAGTCTGCCGAAGGAGGACCTGGCCTTCGTCGACGAGTACGCCGCCCGTACGGAGGCCGAGTCCCG
CTCAGCCGTGATACAGGCCGCCATCGAGTTGCTCAGGCAGGCGCAGCTCGAGCAGGAGTACACGGAGGCTTTCGCCGAAT
GGGACGGAAGCGGAGACGCCGGGCTGTGGGACCGGACGAGCGGAGACGGGATCACCGATGAGGCGTGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Z9JGT1


Antitoxin

Source ID Structure
AlphaFold DB Z9JGL9

References