Detailed information of TA system TA226032

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2664992..2665578
• Replicon: chromosome
• Accession: NZ_CP087692
• Organism: Xylella taiwanensis strain PLS427

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH51_RS11120
• Protein ID: WP_038273324.1
• Coordinates: 2665324..2665578 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH51_RS11115
• Protein ID: WP_038273322.1
• Coordinates: 2664992..2665327 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH51_RS11090 (LPH51_11090)	2660420..2661628	+	1209	WP_038272829.1	hypothetical protein	-
LPH51_RS11095 (LPH51_11095)	2662130..2662450	-	321	WP_038272832.1	hypothetical protein	-
LPH51_RS11100 (LPH51_11100)	2662522..2663238	-	717	WP_160165226.1	portal protein	-
LPH51_RS11105 (LPH51_11105)	2663235..2664341	-	1107	WP_114867106.1	phage terminase large subunit	-
LPH51_RS11110 (LPH51_11110)	2664338..2664739	-	402	WP_114867107.1	lysozyme	-
LPH51_RS11115 (LPH51_11115)	2664992..2665327	-	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH51_RS11120 (LPH51_11120)	2665324..2665578	-	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH51_RS11125 (LPH51_11125)	2665680..2666378	-	699	WP_114867108.1	hypothetical protein	-
LPH51_RS11130 (LPH51_11130)	2666335..2667528	+	1194	WP_230428203.1	hypothetical protein	-
LPH51_RS11135 (LPH51_11135)	2667532..2667804	+	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH51_RS11140 (LPH51_11140)	2667806..2668156	-	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH51_RS11145 (LPH51_11145)	2668232..2669578	+	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH51_RS11150 (LPH51_11150)	2669593..2670477	+	885	WP_114867111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2650253..2685278	35025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T226032 WP_038273324.1 NZ_CP087692:c2665578-2665324 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T226032 NZ_CP121682:c2910928-2910674 [Streptomyces sp. HUAS 5]
GTGAGGCTCGTCTTCGAAGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAGGAGCGACCGCAAGATGCTCGCTCGGAT
CAACAGGCTCATCGAGGACGTCAAACGCGACCCCTTCACTGGGATCGGTAAGCCCGAGCCGCTCAAGTACCACTTGCCAG
GTGCCTGGTCGCGGCGGATCGACGACGAGCACCGCCTGGTCTACCTGGTCACGGACAAGGAGATCGTGATCCTCGCGGCC
CGCTATCACTACTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT226032 WP_038273322.1 NZ_CP087692:c2665327-2664992 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT226032 NZ_CP121682:c2911209-2910925 [Streptomyces sp. HUAS 5]
ATGTCCATCACTGCGAGCGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACAACCACGAGGCCATCGA
GATCGTTTCCAAACACGGCAACGCCGTGCTCATCTCGGCTGAGGACTATGCGGCATTGCGTGAGGGCTCGTACCTGCTGC
GCTCGCCGGCGAACGCTCGCCGGTTGCTCAAGGCGTACGAGAACGCTCTGGCCAACATCAACGTGTCAGAGCGAGAGCTG
ATCGACCCCGACTCGCCGGATGCGGCCAGTGAGGGTGCTGAGTGA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5