Detailed information of TA system TA226030

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-relB/-
• Location: 1858850..1859244
• Replicon: chromosome
• Accession: NZ_CP087692
• Organism: Xylella taiwanensis strain PLS427

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: LPH51_RS07500
• Protein ID: WP_200866186.1
• Coordinates: 1858850..1859053 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Z9JJI0
• Locus tag: LPH51_RS07505
• Protein ID: WP_038270756.1
• Coordinates: 1859050..1859244 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH51_RS07480 (LPH51_07480)	1853864..1854004	+	141	WP_160165149.1	hypothetical protein	-
LPH51_RS07485 (LPH51_07485)	1854391..1855401	-	1011	WP_038270757.1	serine protease	-
LPH51_RS07490 (LPH51_07490)	1856637..1858028	+	1392	WP_051482280.1	right-handed parallel beta-helix repeat-containing protein	-
LPH51_RS07495 (LPH51_07495)	1858101..1858715	-	615	WP_230428270.1	recombinase family protein	-
LPH51_RS07500 (LPH51_07500)	1858850..1859053	-	204	WP_200866186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH51_RS07505 (LPH51_07505)	1859050..1859244	-	195	WP_038270756.1	hypothetical protein	Antitoxin
LPH51_RS07510 (LPH51_07510)	1859488..1859883	+	396	WP_230428271.1	DUF4158 domain-containing protein	-
LPH51_RS07515 (LPH51_07515)	1860012..1860392	+	381	WP_038270750.1	hypothetical protein	-
LPH51_RS07520 (LPH51_07520)	1860526..1860609	+	84	Protein_1485	type II toxin-antitoxin system RelE/ParE family toxin	-
LPH51_RS07525 (LPH51_07525)	1860721..1861002	+	282	WP_038270748.1	XRE family transcriptional regulator	-
LPH51_RS07530 (LPH51_07530)	1861272..1862401	-	1130	Protein_1487	DUF5710 domain-containing protein	-
LPH51_RS07535 (LPH51_07535)	1862577..1863414	+	838	Protein_1488	VirB8/TrbF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-61)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7625.95 Da
• Isoelectric Point: 11.2308

>T226030 WP_200866186.1 NZ_CP087692:c1859053-1858850 [Xylella taiwanensis]
MTLPLHWRTSARDDLASLIRFIAYENPLTARRMKVLIEASVLLASAHPYMFRPGRVPGTREIVAHPN

Nucleotide

• Length: 204 bp

>T226030 NZ_CP121679:3708821-3709102 [Ancylobacter sp. WKF20]
ATGAGCTATGAGCTCGAATTCCTGCCCTCCGCCCGCAAGGAATGGGACAAGCTCGGCGCCACGCTGCGCCAGCAGTTCAA
GAAGAAGCTGGCGGAACGGCTGATCCGCCCGCGCGTGCCGGCCGATGCCCTCAGCGGGATGCCAGACCACTACAAGATCA
AGCTGCGGGCCGCTGGCTATCGCCTGGTCTACCGGGTGGAGGAGGCGCGGATCACCGTAGTGGTCGTCGCAGTCGGCAAA
CGCGAGCGTGGCGACGTCTATGAGGCGGCGCGCCAGCGATAG

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7289.11 Da
• Isoelectric Point: 4.5007

>AT226030 WP_038270756.1 NZ_CP087692:c1859244-1859050 [Xylella taiwanensis]
MKTTPLDPIISEFATEEQAASYDRWFRAKVQASLDDSRPSVPHDQVMAEMDAIIAEAEQHRKQT

Nucleotide

• Length: 195 bp

>AT226030 NZ_CP121679:3708586-3708831 [Ancylobacter sp. WKF20]
ATGCAGCGTGTCGAAGCCGAGATGGCGGTGAGCGTCTCCGACCTCAAGAAGAACCCGACCGCCATTGTCGAGGATGCCCG
CGGCGCGGCGGTGGCGGTGCTGAACCATAACCGCGTCATGGCCTATATGGTGCCGGCCGCCACCTATGAGGCGATGATCG
ACGCGCTGGACGACCGCGCTCTGGTGGAGATCGCCAAGGCCCGCGCCGGCGAGCGTGGCGTGCCGGTCCGCCTTGATGAG
CTATGA

Structures

Antitoxin

• AlphaFold DB: Z9JJI0