Detailed information of TA system TA022603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 2305056..2305824
• Replicon: chromosome
• Accession: NC_010161
• Organism: Bartonella tribocorum CIP 105476

Toxin (Protein)

• Gene name: VbhT
• Uniprot ID: A9IYH2
• Locus tag: BTR_RS10405
• Protein ID: WP_012232419.1
• Coordinates: 2305056..2305649 (-)
• Length: 198 a.a.

Antitoxin (Protein)

• Gene name: VbhA
• Uniprot ID: A9IYH4
• Locus tag: BTR_RS10410
• Protein ID: WP_012232420.1
• Coordinates: 2305636..2305824 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR_RS10370	2300545..2301732	+	1188	WP_012232414.1	type IV secretion system protein VirB10	-
BTR_RS10375	2301796..2302848	+	1053	WP_038474261.1	P-type DNA transfer ATPase VirB11	-
BTR_RS10380	2302997..2303401	+	405	WP_012232416.1	EexN family lipoprotein	-
BTR_RS10390	2303685..2304089	+	405	WP_012232417.1	EexN family lipoprotein	-
BTR_RS10395	2304375..2304755	+	381	WP_012232418.1	EexN family lipoprotein	-
BTR_RS10400	2304802..2304993	+	192	WP_038474268.1	hypothetical protein	-
BTR_RS10405	2305056..2305649	-	594	WP_012232419.1	Fic family protein	Toxin
BTR_RS10410	2305636..2305824	-	189	WP_012232420.1	antitoxin VbhA family protein	Antitoxin
BTR_RS10415	2306021..2306269	-	249	WP_012232421.1	HigA family addiction module antidote protein	-
BTR_RS10420	2306313..2306583	-	271	Protein_1937	type II toxin-antitoxin system RelE/ParE family toxin	-
BTR_RS13040	2306635..2306802	-	168	WP_158305317.1	hypothetical protein	-
BTR_RS10430	2307063..2308424	-	1362	WP_012232423.1	phosphoglucosamine mutase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (55-152)

Antitoxin

• Antitoxin VbhA-like (4-57)

Sequences

Toxin

Protein

• Length: 198 a.a.
• Molecular weight: 22606.42 Da
• Isoelectric Point: 6.5008

>T22603 WP_012232419.1 NC_010161:c2305649-2305056 [Bartonella tribocorum CIP 105476]
VEKYKGGGDPYTDPKTGVMYNRFEIQDKTALERVESTFAYVRSFELMRAATGGKFDLDHMKEIHRKLFGDVYEWAGEIRS
IDIAKGNSMFASYHQIESYTPKITQQLAKEQYLRGLDADEFSQRAGYYMGELNALHPFREGNGRTLREFMGQLAREAGYN
INWDGITREEMTKASIAAHFGNSEHLSVLIRQNLNLL

Nucleotide

• Length: 594 bp

>T22603 NC_010161:c2305649-2305056 [Bartonella tribocorum CIP 105476]
GTGGAGAAATATAAAGGGGGCGGTGATCCTTATACTGATCCTAAAACTGGTGTGATGTATAATCGGTTTGAAATTCAGGA
TAAAACCGCACTGGAGCGTGTAGAATCTACTTTCGCTTATGTAAGGTCTTTTGAACTTATGCGTGCTGCTACGGGTGGTA
AGTTTGATCTCGATCACATGAAAGAGATTCATAGAAAACTGTTTGGTGACGTCTATGAATGGGCGGGAGAGATCCGTTCA
ATAGATATTGCCAAAGGCAATAGTATGTTTGCGAGTTATCATCAGATTGAAAGTTATACACCGAAGATTACGCAACAGCT
TGCAAAAGAACAGTATCTGCGTGGTCTTGATGCAGATGAATTTAGCCAAAGAGCAGGATATTACATGGGAGAGTTGAATG
CCTTGCATCCCTTTCGAGAGGGAAATGGGCGCACGTTGCGTGAATTTATGGGGCAACTTGCTCGTGAAGCTGGTTATAAT
ATCAACTGGGACGGTATCACGCGAGAGGAAATGACAAAGGCATCAATTGCAGCCCATTTTGGGAATTCTGAACACTTGTC
TGTACTTATTCGTCAAAACCTCAATCTCTTATAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7181.31 Da
• Isoelectric Point: 4.8409

>AT22603 WP_012232420.1 NC_010161:c2305824-2305636 [Bartonella tribocorum CIP 105476]
MLSEDEIKRRRFAAKNALASQRLEGLEPDPKVVEQMERVIIGELETSDVIKDLMERIKRGEI

Nucleotide

• Length: 189 bp

>AT22603 NC_010161:c2305824-2305636 [Bartonella tribocorum CIP 105476]
ATGTTGAGTGAAGACGAAATTAAGCGACGTCGCTTTGCTGCTAAAAATGCATTAGCAAGTCAACGTTTAGAGGGGTTGGA
ACCAGATCCAAAAGTCGTGGAGCAAATGGAGCGGGTTATTATTGGAGAACTTGAAACAAGTGATGTAATCAAGGATCTTA
TGGAACGGATAAAACGTGGAGAAATATAA

Structures

Toxin

• AlphaFold DB: A9IYH2

Antitoxin

• AlphaFold DB: A9IYH4