Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 46504..47045 | Replicon | chromosome |
| Accession | NZ_CP087692 | ||
| Organism | Xylella taiwanensis strain PLS427 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Z9JGT1 |
| Locus tag | LPH51_RS00305 | Protein ID | WP_038273166.1 |
| Coordinates | 46722..47045 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | Z9JGL9 |
| Locus tag | LPH51_RS00300 | Protein ID | WP_038273164.1 |
| Coordinates | 46504..46725 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH51_RS00250 (LPH51_00250) | 42080..42316 | - | 237 | WP_230428212.1 | major capsid protein | - |
| LPH51_RS00255 (LPH51_00255) | 42325..42531 | - | 207 | WP_038273075.1 | hypothetical protein | - |
| LPH51_RS00260 (LPH51_00260) | 42534..42848 | - | 315 | WP_230428211.1 | hypothetical protein | - |
| LPH51_RS00265 (LPH51_00265) | 43124..43711 | - | 588 | WP_038273076.1 | hypothetical protein | - |
| LPH51_RS00270 (LPH51_00270) | 43908..44051 | - | 144 | WP_160165233.1 | hypothetical protein | - |
| LPH51_RS00275 (LPH51_00275) | 44171..44371 | - | 201 | WP_038273077.1 | hypothetical protein | - |
| LPH51_RS00280 (LPH51_00280) | 44420..44683 | - | 264 | WP_162814095.1 | hypothetical protein | - |
| LPH51_RS00285 (LPH51_00285) | 44687..44848 | - | 162 | WP_160165236.1 | hypothetical protein | - |
| LPH51_RS00290 (LPH51_00290) | 45138..45467 | + | 330 | WP_230428286.1 | DUF3693 domain-containing protein | - |
| LPH51_RS00295 (LPH51_00295) | 45556..46056 | - | 501 | Protein_58 | tyrosine-type recombinase/integrase | - |
| LPH51_RS00300 (LPH51_00300) | 46504..46725 | + | 222 | WP_038273164.1 | antitoxin MazE family protein | Antitoxin |
| LPH51_RS00305 (LPH51_00305) | 46722..47045 | + | 324 | WP_038273166.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LPH51_RS00310 (LPH51_00310) | 47146..48294 | - | 1149 | WP_069636227.1 | zonular occludens toxin domain-containing protein | - |
| LPH51_RS00315 (LPH51_00315) | 48294..48635 | - | 342 | WP_038273089.1 | DUF2523 family protein | - |
| LPH51_RS00320 (LPH51_00320) | 48639..49706 | - | 1068 | WP_152536670.1 | virulence factor TspB C-terminal domain-related protein | - |
| LPH51_RS00325 (LPH51_00325) | 50174..50392 | - | 219 | WP_051482398.1 | major capsid protein | - |
| LPH51_RS00330 (LPH51_00330) | 50401..50610 | - | 210 | WP_230428208.1 | hypothetical protein | - |
| LPH51_RS00335 (LPH51_00335) | 50610..50903 | - | 294 | WP_038273093.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 28928..58413 | 29485 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 11807.97 Da Isoelectric Point: 9.1188
>T226029 WP_038273166.1 NZ_CP087692:46722-47045 [Xylella taiwanensis]
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
Download Length: 324 bp
>T226029 NZ_CP121679:c1985354-1985073 [Ancylobacter sp. WKF20]
ATGATCCTCAACTTCCGGGACAAACGTACCGCCGCGGTCTGGGCCGGCCAGGTCGGCAAGGGCTTCCCGGCCGATCTAGT
GCGCGGCGCGCAGCGCAAGCTGGCGATGATTCACGCTGCGGTGACGCTCGACGCTTTGCGGGCGCCCCCGGCCAATCGGC
TTGAGGTTCTGAAGGGTGATCGTGCCGGCCAGCACTCCATCCGCATCAATGATCAGTTCCGCATCTGCTTCATCTGGCGC
GACGGCCATGCCGCCGACGTCGAGATCACCGACTATCACTGA
ATGATCCTCAACTTCCGGGACAAACGTACCGCCGCGGTCTGGGCCGGCCAGGTCGGCAAGGGCTTCCCGGCCGATCTAGT
GCGCGGCGCGCAGCGCAAGCTGGCGATGATTCACGCTGCGGTGACGCTCGACGCTTTGCGGGCGCCCCCGGCCAATCGGC
TTGAGGTTCTGAAGGGTGATCGTGCCGGCCAGCACTCCATCCGCATCAATGATCAGTTCCGCATCTGCTTCATCTGGCGC
GACGGCCATGCCGCCGACGTCGAGATCACCGACTATCACTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8490.65 Da Isoelectric Point: 8.0827
>AT226029 WP_038273164.1 NZ_CP087692:46504-46725 [Xylella taiwanensis]
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
Download Length: 222 bp
>AT226029 NZ_CP121679:c1985062-1984772 [Ancylobacter sp. WKF20]
ATGATCGGCCCGAACCCGCCTATTCATCCCGGCGAGGTCCTGCGCGAGGAGTTTCTCGCGCCGATGGGTCTCAAGCCTTA
CGGCCTTGCCAAGGCACTGCACGTGCCGCGCACGCGAATCGAGCGGCTGGCGCGCGAGGAGGCGCCGGTCACGGCCGACA
CCGCGCTCCGGCTCGGCCGCTATTTCGGCACCGGGCCGGAATTCTGGATGAATCTTCAGTCCGCCTATGATCTCGCAATC
ACGGTGGCGGCGGCGCCGGACATTGCGGCGATCACACCGCGCGCCGCCTGA
ATGATCGGCCCGAACCCGCCTATTCATCCCGGCGAGGTCCTGCGCGAGGAGTTTCTCGCGCCGATGGGTCTCAAGCCTTA
CGGCCTTGCCAAGGCACTGCACGTGCCGCGCACGCGAATCGAGCGGCTGGCGCGCGAGGAGGCGCCGGTCACGGCCGACA
CCGCGCTCCGGCTCGGCCGCTATTTCGGCACCGGGCCGGAATTCTGGATGAATCTTCAGTCCGCCTATGATCTCGCAATC
ACGGTGGCGGCGGCGCCGGACATTGCGGCGATCACACCGCGCGCCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|