Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 1463322..1463863 | Replicon | chromosome |
| Accession | NZ_CP087691 | ||
| Organism | Xylella taiwanensis strain PLS422 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Z9JGT1 |
| Locus tag | LPH48_RS06455 | Protein ID | WP_038273166.1 |
| Coordinates | 1463540..1463863 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | Z9JGL9 |
| Locus tag | LPH48_RS06450 | Protein ID | WP_038273164.1 |
| Coordinates | 1463322..1463543 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH48_RS06400 (LPH48_06400) | 1458898..1459134 | - | 237 | WP_230428212.1 | major capsid protein | - |
| LPH48_RS06405 (LPH48_06405) | 1459143..1459349 | - | 207 | WP_038273075.1 | hypothetical protein | - |
| LPH48_RS06410 (LPH48_06410) | 1459352..1459666 | - | 315 | WP_230428211.1 | hypothetical protein | - |
| LPH48_RS06415 (LPH48_06415) | 1459942..1460529 | - | 588 | WP_038273076.1 | hypothetical protein | - |
| LPH48_RS06420 (LPH48_06420) | 1460726..1460869 | - | 144 | WP_160165233.1 | hypothetical protein | - |
| LPH48_RS06425 (LPH48_06425) | 1460989..1461189 | - | 201 | WP_038273077.1 | hypothetical protein | - |
| LPH48_RS06430 (LPH48_06430) | 1461238..1461501 | - | 264 | WP_162814095.1 | hypothetical protein | - |
| LPH48_RS06435 (LPH48_06435) | 1461505..1461666 | - | 162 | WP_160165236.1 | hypothetical protein | - |
| LPH48_RS06440 (LPH48_06440) | 1461956..1462285 | + | 330 | WP_230428286.1 | DUF3693 domain-containing protein | - |
| LPH48_RS06445 (LPH48_06445) | 1462374..1462874 | - | 501 | Protein_1262 | tyrosine-type recombinase/integrase | - |
| LPH48_RS06450 (LPH48_06450) | 1463322..1463543 | + | 222 | WP_038273164.1 | antitoxin MazE family protein | Antitoxin |
| LPH48_RS06455 (LPH48_06455) | 1463540..1463863 | + | 324 | WP_038273166.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LPH48_RS06460 (LPH48_06460) | 1463964..1465112 | - | 1149 | WP_069636227.1 | zonular occludens toxin domain-containing protein | - |
| LPH48_RS06465 (LPH48_06465) | 1465112..1465453 | - | 342 | WP_038273089.1 | DUF2523 family protein | - |
| LPH48_RS06470 (LPH48_06470) | 1465457..1466524 | - | 1068 | WP_152536670.1 | virulence factor TspB C-terminal domain-related protein | - |
| LPH48_RS06475 (LPH48_06475) | 1466992..1467210 | - | 219 | WP_051482398.1 | major capsid protein | - |
| LPH48_RS06480 (LPH48_06480) | 1467219..1467428 | - | 210 | WP_230428208.1 | hypothetical protein | - |
| LPH48_RS06485 (LPH48_06485) | 1467428..1467721 | - | 294 | WP_038273093.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1414840..1471098 | 56258 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 11807.97 Da Isoelectric Point: 9.1188
>T226026 WP_038273166.1 NZ_CP087691:1463540-1463863 [Xylella taiwanensis]
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
Download Length: 324 bp
>T226026 NZ_CP121668:9191815-9192003 [Bradyrhizobium sp. CB2312]
ATGAATAGCCGAGACATCATCTCGGCCCTTCAGAGGGATGGCTGGGTCCAGGCGGCTCAAAAAGGCAGCCACGTCCAACT
CAAGCACCCAACGAAACCAGGTCGCGTCACCGTCCCTCATCCGAATCGGGACATCCCGCTAGGGACATTAAAGAGCATCG
AGCGGCCGTCCGGCCTGAAGCTGAGGTGA
ATGAATAGCCGAGACATCATCTCGGCCCTTCAGAGGGATGGCTGGGTCCAGGCGGCTCAAAAAGGCAGCCACGTCCAACT
CAAGCACCCAACGAAACCAGGTCGCGTCACCGTCCCTCATCCGAATCGGGACATCCCGCTAGGGACATTAAAGAGCATCG
AGCGGCCGTCCGGCCTGAAGCTGAGGTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8490.65 Da Isoelectric Point: 8.0827
>AT226026 WP_038273164.1 NZ_CP087691:1463322-1463543 [Xylella taiwanensis]
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
Download Length: 222 bp
>AT226026 NZ_CP121668:9192009-9192407 [Bradyrhizobium sp. CB2312]
ATGCGTCATTACATCGGTCTCATCCATAAAGATGCCGACAGCGATTTCGGCGTGTCGTTTCCCGATCTGCCGGGCCTTGT
CACCGCAGGGACCACGCTCGATGAAGCGCGCGACGTGGCCGAGGAAGCGCTAGCGCTTCATCTCGAAGGCATGGCTCAAG
ACGGCGAAGCCATTCCCGCGCCATCGTCGCTCGAGCAGATCATGTCGGATCCAGAGAACCGCTCGGGCGTTGCCATTCTG
GTGTCGGTGAAGGACGCGCAGCCAAAGATCGTCCGCGTCAATGTCACCTTGCCCGGCGATGTGCTGGAGCAAATCGATAA
ATACGCCGAGGCCCACGGCTACACGCGATCGGGCCTGCTTGCGCAAGCCGCCAAGAAGCTGATGACCGAGACGGTCTGA
ATGCGTCATTACATCGGTCTCATCCATAAAGATGCCGACAGCGATTTCGGCGTGTCGTTTCCCGATCTGCCGGGCCTTGT
CACCGCAGGGACCACGCTCGATGAAGCGCGCGACGTGGCCGAGGAAGCGCTAGCGCTTCATCTCGAAGGCATGGCTCAAG
ACGGCGAAGCCATTCCCGCGCCATCGTCGCTCGAGCAGATCATGTCGGATCCAGAGAACCGCTCGGGCGTTGCCATTCTG
GTGTCGGTGAAGGACGCGCAGCCAAAGATCGTCCGCGTCAATGTCACCTTGCCCGGCGATGTGCTGGAGCAAATCGATAA
ATACGCCGAGGCCCACGGCTACACGCGATCGGGCCTGCTTGCGCAAGCCGCCAAGAAGCTGATGACCGAGACGGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|