Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1447635..1448320 Replicon chromosome
Accession NZ_CP087691
Organism Xylella taiwanensis strain PLS422

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LPH48_RS06300 Protein ID WP_200866210.1
Coordinates 1447635..1448039 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LPH48_RS06305 Protein ID WP_038272460.1
Coordinates 1448048..1448320 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPH48_RS06285 (LPH48_06285) 1444235..1446310 + 2076 WP_230428285.1 S46 family peptidase -
LPH48_RS06290 (LPH48_06290) 1446417..1447061 + 645 WP_038272466.1 histidine phosphatase family protein -
LPH48_RS06295 (LPH48_06295) 1447228..1447572 + 345 WP_038272464.1 DUF3653 domain-containing protein -
LPH48_RS06300 (LPH48_06300) 1447635..1448039 - 405 WP_200866210.1 type II toxin-antitoxin system VapC family toxin Toxin
LPH48_RS06305 (LPH48_06305) 1448048..1448320 - 273 WP_038272460.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LPH48_RS06310 (LPH48_06310) 1448410..1449537 - 1128 WP_114867127.1 zonular occludens toxin domain-containing protein -
LPH48_RS06315 (LPH48_06315) 1449550..1449894 - 345 WP_038273069.1 DUF2523 family protein -
LPH48_RS06320 (LPH48_06320) 1449897..1451282 - 1386 WP_230428213.1 furin-like repeat-containing protein -
LPH48_RS06325 (LPH48_06325) 1451462..1451698 - 237 WP_230428212.1 major capsid protein -
LPH48_RS06330 (LPH48_06330) 1451707..1451913 - 207 WP_038273075.1 hypothetical protein -
LPH48_RS06335 (LPH48_06335) 1451916..1452230 - 315 WP_230428211.1 hypothetical protein -
LPH48_RS06340 (LPH48_06340) 1452506..1453093 - 588 WP_038273076.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1414840..1471098 56258


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

SpoVT-AbrB domain

(16-52)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14775.44 Da        Isoelectric Point: 6.9054

>T226024 WP_200866210.1 NZ_CP087691:c1448039-1447635 [Xylella taiwanensis]
MLDTNIISDMIRNPFGLVACRIEKVDPKEVCTSIVVAAELRYGCAKKGSTKLLAKVKLMLETIPVLPLDIPTDAEYGRIR
AELESVGQTIGLNDLLIGTHAYVLGMTLVTDNVKEFKRIRGLKIENWLECASSV

Download         Length: 405 bp

>T226024 NZ_CP121668:6964485-6964766 [Bradyrhizobium sp. CB2312]
GTGATCAGAACGTTTCGGGACAAAACCACTGAAGCGGTCTTTAACGGCGAAAGTCCAAAGGGCTTTCCGGCCGACCTCGT
GAAGGTTGCGCGGCGGAAGTTGCGCTATCTTCACGCGGCCGCCGAGCTCGGCGACTTAAGGGCGCCGCCCGGCAACCGCC
TCGAAGCCTTGGCAGGCGATCGCAAGGGACAGCACTCGATCAGGATCAACGATCAATTCCGAGTGTGCTTCATCTGGACC
GCGGAAGGTCCCGCTGAGGTCGAGATCGTGGACTATCACTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10331.95 Da        Isoelectric Point: 4.5216

>AT226024 WP_038272460.1 NZ_CP087691:c1448320-1448048 [Xylella taiwanensis]
MSISMPSSRLKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPVSMPTNIIELLAQWKTEDPLGLEDQFPEIE
DMLAKPDDIF

Download         Length: 273 bp

>AT226024 NZ_CP121668:6964779-6965084 [Bradyrhizobium sp. CB2312]
ATGGCGAGAAAGCTCAAGCCCATGCATCCTGGTGAGGTTCTGCGGGAAGAATTTCTGATCCCGCTGAACATGTCCGCCGG
CGCGCTCGCCAAGACATGCGGCCTGCCGCGCACGCGCCTTGAGCGGATTGCGAGTGAGCAGACCGGGATTACCGCCGACA
CGGCACTTCGGCTTGGCAAGGCGCTCGGCACGACCGCCGAACTTTGGCTCAATCTTCAGAACGATTTCGACATCCAGATC
GCCAAACGCGATCTCGGCAAGGCGCTCGATCGCATCGAGACCGTCAACAAGCCCAAAGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References