Detailed information of TA system TA226023

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1256930..1257516
• Replicon: chromosome
• Accession: NZ_CP087691
• Organism: Xylella taiwanensis strain PLS422

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH48_RS05365
• Protein ID: WP_038273324.1
• Coordinates: 1257262..1257516 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH48_RS05360
• Protein ID: WP_038273322.1
• Coordinates: 1256930..1257265 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH48_RS05335 (LPH48_05335)	1252358..1253566	+	1209	WP_038272829.1	hypothetical protein	-
LPH48_RS05340 (LPH48_05340)	1254068..1254388	-	321	WP_038272832.1	hypothetical protein	-
LPH48_RS05345 (LPH48_05345)	1254460..1255176	-	717	WP_160165226.1	portal protein	-
LPH48_RS05350 (LPH48_05350)	1255173..1256279	-	1107	WP_114867106.1	phage terminase large subunit	-
LPH48_RS05355 (LPH48_05355)	1256276..1256677	-	402	WP_114867107.1	lysozyme	-
LPH48_RS05360 (LPH48_05360)	1256930..1257265	-	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH48_RS05365 (LPH48_05365)	1257262..1257516	-	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH48_RS05370 (LPH48_05370)	1257618..1258316	-	699	WP_114867108.1	hypothetical protein	-
LPH48_RS05375 (LPH48_05375)	1258273..1259466	+	1194	WP_230428203.1	hypothetical protein	-
LPH48_RS05380 (LPH48_05380)	1259470..1259742	+	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH48_RS05385 (LPH48_05385)	1259744..1260094	-	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH48_RS05390 (LPH48_05390)	1260170..1261516	+	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH48_RS05395 (LPH48_05395)	1261531..1262415	+	885	WP_114867111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1242191..1272212	30021

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T226023 WP_038273324.1 NZ_CP087691:c1257516-1257262 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T226023 NZ_CP121668:536958-537359 [Bradyrhizobium sp. CB2312]
GTGAGTGCTTTCTTCGACAGCAATATCCTGATCTACGCCTACTCAACGGACACAAGGCGGCAGCGGGCGCTGACGACGAT
TGCCGGCGGTGGCATCATCAGCGCGCAGGTGCTGAACGAGTTCACCAACGTGCTGCGCAAGAAGCAAAGGCAGGATTGGC
CGGTGATCGAGGCGGCCGTGCAGTCTCTGCGCTTCCGCTTTCCAGACATCGTGCCGCTGACGTCGGACACGCACACTGCG
GCGCTTGCGCTCGCGCGCGACCACACGCTCGCCTTCTATGACGCCCTGATCGTCGCCGCCGCGATCGAGGCCGGCTGCGA
CACGCTCTACAGCGAAGACCTGCAACACAGCCGCAGCTTCAGTGGGCTCACCATCGTCAATCCGTTTCTTGGCAGCACGT
GA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT226023 WP_038273322.1 NZ_CP087691:c1257265-1256930 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT226023 NZ_CP121668:536731-536961 [Bradyrhizobium sp. CB2312]
GTGCTGGTTTCCAAGTGGGGAAATAGCTTGGCGGTTCGGCTGCCCAAGGCACTCGTTGAGGCTCTGAAGCTTTCACCGGG
CGACGAGCTCAATGTGGTGGAAGCCTCGAAGGGCCGGCTCGCAGTGGAGAAGGTTGACAAGCGCGCGGAATTTCTCCGGC
AGGTCGAGCAGTTCCAGTTTCCGTTGCCTGAAGACTACAAATTCGACCGCGACGAAGCGAACGAGCGGTGA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5