Detailed information of TA system TA226021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-relB/-
• Location: 450772..451166
• Replicon: chromosome
• Accession: NZ_CP087691
• Organism: Xylella taiwanensis strain PLS422

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: LPH48_RS01735
• Protein ID: WP_200866186.1
• Coordinates: 450772..450975 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Z9JJI0
• Locus tag: LPH48_RS01740
• Protein ID: WP_038270756.1
• Coordinates: 450972..451166 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH48_RS01715 (LPH48_01715)	445786..445926	+	141	WP_160165149.1	hypothetical protein	-
LPH48_RS01720 (LPH48_01720)	446313..447323	-	1011	WP_038270757.1	serine protease	-
LPH48_RS01725 (LPH48_01725)	448559..449950	+	1392	WP_051482280.1	right-handed parallel beta-helix repeat-containing protein	-
LPH48_RS01730 (LPH48_01730)	450023..450637	-	615	WP_230428270.1	recombinase family protein	-
LPH48_RS01735 (LPH48_01735)	450772..450975	-	204	WP_200866186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH48_RS01740 (LPH48_01740)	450972..451166	-	195	WP_038270756.1	hypothetical protein	Antitoxin
LPH48_RS01745 (LPH48_01745)	451410..451805	+	396	WP_230428271.1	DUF4158 domain-containing protein	-
LPH48_RS01750 (LPH48_01750)	451934..452314	+	381	WP_038270750.1	hypothetical protein	-
LPH48_RS01755 (LPH48_01755)	452448..452531	+	84	Protein_338	type II toxin-antitoxin system RelE/ParE family toxin	-
LPH48_RS01760 (LPH48_01760)	452643..452924	+	282	WP_038270748.1	XRE family transcriptional regulator	-
LPH48_RS01765 (LPH48_01765)	453194..454323	-	1130	Protein_340	DUF5710 domain-containing protein	-
LPH48_RS01770 (LPH48_01770)	454499..455336	+	838	Protein_341	VirB8/TrbF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-61)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7625.95 Da
• Isoelectric Point: 11.2308

>T226021 WP_200866186.1 NZ_CP087691:c450975-450772 [Xylella taiwanensis]
MTLPLHWRTSARDDLASLIRFIAYENPLTARRMKVLIEASVLLASAHPYMFRPGRVPGTREIVAHPN

Nucleotide

• Length: 204 bp

>T226021 NZ_CP121666:c748657-748244 [Bradyrhizobium sp. CB1717]
GTGACCGCGTTTCTGGATACGAACATTCTCGTCTACGCCCAGCAGAGGGGCACCAAGGCGAAGATCTCGCAAGACCTGAT
CGACGAGGGCGGCACCATCAGTGTGCAAGTCCTGAACGAACTCGCAAACGTCTTGAGCAAGAAGCAGGGCCGAAGCTGGC
GCGACATCGAGCTTGTGTTCGATGACATCGACAATGCGCTCGATCCGGTGTTGCCGCTGACGGCAACGACCAGTCGTGCG
GCCCTTGCGCTCGCGCGAGATGATGGCTTCGCCTTCTATGATGCGCTGATCGTTGCCGCCGCGATCGAAGCCGGCTGCGA
TATCCTTTACAGCGAAGACATGCAGCATGGCCGCAGCATCGGCGGGCTCACCATCGTCAATCCGTTTCTTGGCAGTGCTT
CACCGTCACCCTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7289.11 Da
• Isoelectric Point: 4.5007

>AT226021 WP_038270756.1 NZ_CP087691:c451166-450972 [Xylella taiwanensis]
MKTTPLDPIISEFATEEQAASYDRWFRAKVQASLDDSRPSVPHDQVMAEMDAIIAEAEQHRKQT

Nucleotide

• Length: 195 bp

>AT226021 NZ_CP121666:c748890-748654 [Bradyrhizobium sp. CB1717]
ATGCAAGTTTCCAAATGGGGCAACAGCCTTGCTGTCCGCTTGCCCAAGGCGCTTGTGGAGGAGCTGGGCCTCAAAGAAGG
CGATGAACTCGAGGTGGTCGCGGCCCGAAAAGGCGCGATAGAGGTCGAGACCAAGGAAGAACGGCGCCGCCGAGCGATAG
AGAATATGCGCGCACGCAACTGGCCGCCCTTGCCTGCTGATTACAAGTTCGATCGCGACGAGGCGAACGAGCGGTGA

Structures

Antitoxin

• AlphaFold DB: Z9JJI0