22602

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 2255696..2256269 Replicon chromosome
Accession NC_010161
Organism Bartonella tribocorum CIP 105476

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B9CX33
Locus tag BTR_RS10060 Protein ID WP_012232364.1
Coordinates 2255696..2256004 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B9CYS4
Locus tag BTR_RS10065 Protein ID WP_012232365.1
Coordinates 2255985..2256269 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTR_RS12015 2250856..2252151 - 1296 WP_012232359.1 hypothetical protein -
BTR_RS10040 2252186..2253037 - 852 WP_012232360.1 hypothetical protein -
BTR_RS10045 2253039..2253464 - 426 WP_012232361.1 hypothetical protein -
BTR_RS10050 2253464..2254921 - 1458 WP_012232362.1 hypothetical protein -
BTR_RS10055 2254923..2255630 - 708 WP_012232363.1 hypothetical protein -
BTR_RS10060 2255696..2256004 + 309 WP_012232364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTR_RS10065 2255985..2256269 + 285 WP_012232365.1 putative addiction module antidote protein Antitoxin
BTR_RS10070 2256305..2256685 - 381 WP_012232366.1 hypothetical protein -
BTR_RS10075 2256696..2257076 - 381 WP_012232367.1 hypothetical protein -
BTR_RS10080 2257099..2258226 - 1128 WP_012232368.1 N4-gp56 family major capsid protein -
BTR_RS10085 2258320..2259207 - 888 WP_012232369.1 hypothetical protein -
BTR_RS10090 2259221..2261239 - 2019 WP_012232370.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2232769..2286523 53754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11876.83 Da        Isoelectric Point: 9.9055

>T22602 WP_012232364.1 NC_010161:2255696-2256004 [Bartonella tribocorum CIP 105476]
MIFIHKTIEFDNWLKKLKDKKAKAIILQRVVRLKQGLLGDVKFFNSIGEVRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QQRDIEQALKLKEEYSDENNPI

Download         Length: 309 bp

>T22602 NC_010161:2255696-2256004 [Bartonella tribocorum CIP 105476]
ATGATATTCATTCATAAAACGATAGAATTTGATAATTGGCTTAAGAAACTCAAAGATAAAAAGGCTAAAGCGATTATTCT
TCAACGTGTTGTACGCTTAAAACAAGGACTTTTGGGTGATGTTAAGTTCTTCAATAGCATAGGTGAAGTACGCATCCACT
ATGGTGCTGGTTACAGAATTTATTTTACCCAAAAAGGCTCTGATTTTATCCTTTTGTTATGTGGTGGAGATAAATCAACG
CAGCAAAGGGATATCGAACAAGCGTTAAAGTTAAAAGAGGAGTACAGTGATGAAAACAACCCCATTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10329.73 Da        Isoelectric Point: 7.0111

>AT22602 WP_012232365.1 NC_010161:2255985-2256269 [Bartonella tribocorum CIP 105476]
MKTTPFKPEEYLEDIEVQQAFLNEAFKTGDAAHIADAIGIVARSQNMRALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLFVQSSTS

Download         Length: 285 bp

>AT22602 NC_010161:2255985-2256269 [Bartonella tribocorum CIP 105476]
ATGAAAACAACCCCATTTAAACCAGAAGAATATCTTGAAGACATTGAAGTACAACAAGCATTTCTCAATGAAGCCTTCAA
AACTGGTGATGCCGCTCATATAGCGGATGCCATTGGTATCGTTGCTCGCTCTCAAAATATGCGTGCTTTAGCAAAAGAAA
CCAATCGCGAACGCAGTGGATTATATCGCTCCTTAAGTAAAACGGGTGACCCCAAGCTTTCTACTTTAGTCGCTGTCTTA
TCTGCCCTTAACCTGCAACTCTTTGTACAGTCTTCTACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B9CX33

Antitoxin

Source ID Structure
AlphaFold DB A0A5B9CYS4

References