Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 38897..39438 | Replicon | chromosome |
| Accession | NZ_CP087689 | ||
| Organism | Xylella taiwanensis strain PLS415 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Z9JGT1 |
| Locus tag | LPH50_RS00225 | Protein ID | WP_038273166.1 |
| Coordinates | 39115..39438 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | Z9JGL9 |
| Locus tag | LPH50_RS00220 | Protein ID | WP_038273164.1 |
| Coordinates | 38897..39118 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH50_RS00170 (LPH50_00170) | 34473..34709 | - | 237 | WP_230428212.1 | major capsid protein | - |
| LPH50_RS00175 (LPH50_00175) | 34718..34924 | - | 207 | WP_038273075.1 | hypothetical protein | - |
| LPH50_RS00180 (LPH50_00180) | 34927..35241 | - | 315 | WP_230428211.1 | hypothetical protein | - |
| LPH50_RS00185 (LPH50_00185) | 35517..36104 | - | 588 | WP_038273076.1 | hypothetical protein | - |
| LPH50_RS00190 (LPH50_00190) | 36301..36444 | - | 144 | WP_160165233.1 | hypothetical protein | - |
| LPH50_RS00195 (LPH50_00195) | 36564..36764 | - | 201 | WP_038273077.1 | hypothetical protein | - |
| LPH50_RS00200 (LPH50_00200) | 36813..37076 | - | 264 | WP_162814095.1 | hypothetical protein | - |
| LPH50_RS00205 (LPH50_00205) | 37080..37241 | - | 162 | WP_160165236.1 | hypothetical protein | - |
| LPH50_RS00210 (LPH50_00210) | 37531..37860 | + | 330 | WP_230428286.1 | DUF3693 domain-containing protein | - |
| LPH50_RS00215 (LPH50_00215) | 37949..38449 | - | 501 | Protein_42 | tyrosine-type recombinase/integrase | - |
| LPH50_RS00220 (LPH50_00220) | 38897..39118 | + | 222 | WP_038273164.1 | antitoxin MazE family protein | Antitoxin |
| LPH50_RS00225 (LPH50_00225) | 39115..39438 | + | 324 | WP_038273166.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LPH50_RS00230 (LPH50_00230) | 39539..40687 | - | 1149 | WP_069636227.1 | zonular occludens toxin domain-containing protein | - |
| LPH50_RS00235 (LPH50_00235) | 40687..41028 | - | 342 | WP_038273089.1 | DUF2523 family protein | - |
| LPH50_RS00240 (LPH50_00240) | 41032..42099 | - | 1068 | WP_152536670.1 | virulence factor TspB C-terminal domain-related protein | - |
| LPH50_RS00245 (LPH50_00245) | 42567..42785 | - | 219 | WP_051482398.1 | major capsid protein | - |
| LPH50_RS00250 (LPH50_00250) | 42794..43003 | - | 210 | WP_230428208.1 | hypothetical protein | - |
| LPH50_RS00255 (LPH50_00255) | 43003..43296 | - | 294 | WP_038273093.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 30420..50806 | 20386 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 11807.97 Da Isoelectric Point: 9.1188
>T226011 WP_038273166.1 NZ_CP087689:39115-39438 [Xylella taiwanensis]
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
Download Length: 324 bp
>T226011 NZ_CP121660:1544033-1544437 [Sinorhizobium terangae]
GTGATCTCGCATCTTCTCGACACCAATGCCGTCATTGCCTTGATCGGCCGCAAATCGGATACATTGGTCAGCCGTGTACT
CGATAGCCCTCAGGGCAGTATCGGCCTGCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAGAAGCGCAAAGG
TCCAACACAACCTCGAAACCTTGCGTTTATTGATGGCGGATTTTCCGATCCTCGACTTTGACCAGAACGATGCCTTTGTC
GCGGGCGCGATCCGAGCCGCCCTTGCGGCGAAGGGGACGCCCATCGGCCCCTATGATGTGCTGATCGCGGGACAGGCGAA
AGCCCGCGGACTGACACTCGTCACCAACAATGGCGGCGAGTTCAACAGGGTTGAGAATCTACGTGTGGAGGACTGGTCGC
TTTGA
GTGATCTCGCATCTTCTCGACACCAATGCCGTCATTGCCTTGATCGGCCGCAAATCGGATACATTGGTCAGCCGTGTACT
CGATAGCCCTCAGGGCAGTATCGGCCTGCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAGAAGCGCAAAGG
TCCAACACAACCTCGAAACCTTGCGTTTATTGATGGCGGATTTTCCGATCCTCGACTTTGACCAGAACGATGCCTTTGTC
GCGGGCGCGATCCGAGCCGCCCTTGCGGCGAAGGGGACGCCCATCGGCCCCTATGATGTGCTGATCGCGGGACAGGCGAA
AGCCCGCGGACTGACACTCGTCACCAACAATGGCGGCGAGTTCAACAGGGTTGAGAATCTACGTGTGGAGGACTGGTCGC
TTTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8490.65 Da Isoelectric Point: 8.0827
>AT226011 WP_038273164.1 NZ_CP087689:38897-39118 [Xylella taiwanensis]
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
Download Length: 222 bp
>AT226011 NZ_CP121660:1543776-1544036 [Sinorhizobium terangae]
ATGCCCCATCTTGCACGGGTATTCCAGTCCGGAAATTCGCAGGCTGTTCGCCTGCCGAAAGAATTCCGCTTCAACGTCGA
CCGCGTGGAGATCACGCCGGAGGGCGATGCCCTCATTCTGCGCCCGCATGTCGAGGAGGCCGAGCCGTGGTCGTCGCTGA
AGGCAGCGCTGGTCCGTGGCATGAGTGAAGACTTTATGGAGAGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGCCAGAC
ATTGACGCGGTGTTTCGGTGA
ATGCCCCATCTTGCACGGGTATTCCAGTCCGGAAATTCGCAGGCTGTTCGCCTGCCGAAAGAATTCCGCTTCAACGTCGA
CCGCGTGGAGATCACGCCGGAGGGCGATGCCCTCATTCTGCGCCCGCATGTCGAGGAGGCCGAGCCGTGGTCGTCGCTGA
AGGCAGCGCTGGTCCGTGGCATGAGTGAAGACTTTATGGAGAGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGCCAGAC
ATTGACGCGGTGTTTCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|