Detailed information of TA system TA022601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/RelE(toxin)
• Location: 2114050..2114528
• Replicon: chromosome
• Accession: NC_010161
• Organism: Bartonella tribocorum CIP 105476

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: BTR_RS09305
• Protein ID: WP_038473997.1
• Coordinates: 2114241..2114528 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: BTR_RS09300
• Protein ID: WP_038473994.1
• Coordinates: 2114050..2114241 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR_RS12915	2110668..2110838	-	171	WP_158305295.1	hypothetical protein	-
BTR_RS12920	2111105..2111269	-	165	WP_158305296.1	hypothetical protein	-
BTR_RS12925	2111352..2111510	-	159	WP_158305297.1	hypothetical protein	-
BTR_RS09290	2112295..2112510	-	216	WP_038473992.1	hypothetical protein	-
BTR_RS09295	2113312..2113719	+	408	WP_012232283.1	helix-turn-helix domain-containing protein	-
BTR_RS09300	2114050..2114241	+	192	WP_038473994.1	hypothetical protein	Antitoxin
BTR_RS09305	2114241..2114528	+	288	WP_038473997.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTR_RS09310	2115018..2115410	-	393	WP_038474003.1	hypothetical protein	-
BTR_RS09325	2116746..2117167	+	422	Protein_1730	helix-turn-helix transcriptional regulator	-
BTR_RS09330	2117249..2117647	-	399	WP_012232286.1	type II toxin-antitoxin system VapC family toxin	-
BTR_RS09335	2117644..2117895	-	252	WP_005774741.1	DNA-binding protein	-
BTR_RS09340	2118668..2119057	+	390	WP_012232287.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11073.07 Da
• Isoelectric Point: 9.9304

>T22601 WP_038473997.1 NC_010161:2114241-2114528 [Bartonella tribocorum CIP 105476]
MLPIIWLACARDDLNKILTYIAYESPPAARRMKRLLEDSVLPLAEHPYLYRQSEKVPGLREVLAHPNYLILYRVTKTQIE
ITSVVHARRKFPIST

Nucleotide

• Length: 288 bp

>T22601 NC_010161:2114241-2114528 [Bartonella tribocorum CIP 105476]
ATGTTACCCATTATCTGGTTGGCTTGTGCTCGCGATGATTTAAATAAAATTTTAACTTATATTGCTTATGAAAGTCCGCC
TGCTGCACGACGAATGAAGAGGCTTTTAGAAGATTCTGTACTCCCATTAGCTGAACATCCATACCTATACCGCCAAAGTG
AGAAAGTCCCGGGATTACGAGAAGTTTTAGCCCATCCAAACTATCTTATATTGTACAGAGTAACGAAAACACAAATAGAG
ATCACCTCTGTGGTACATGCTCGCCGTAAATTTCCTATCTCCACCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7274.21 Da
• Isoelectric Point: 4.3210

>AT22601 WP_038473994.1 NC_010161:2114050-2114241 [Bartonella tribocorum CIP 105476]
MKTVLSPLISEFETVEEETDYTAWLREKVRVSLANPHPTISHDEVMAEMDNIIDQIEAEKKKS

Nucleotide

• Length: 192 bp

>AT22601 NC_010161:2114050-2114241 [Bartonella tribocorum CIP 105476]
ATGAAGACTGTTCTTTCTCCGCTAATTTCAGAATTCGAAACCGTGGAAGAGGAAACGGATTACACCGCGTGGTTGCGTGA
AAAGGTAAGAGTTAGCCTTGCAAATCCTCATCCTACTATCTCACACGACGAAGTTATGGCTGAAATGGATAATATAATAG
ACCAAATTGAAGCTGAAAAAAAGAAGTCCTAA