Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 2657424..2658010 | Replicon | chromosome |
| Accession | NZ_CP087688 | ||
| Organism | Xylella taiwanensis strain PLS413 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Z9JFU4 |
| Locus tag | LPH64_RS11065 | Protein ID | WP_038273324.1 |
| Coordinates | 2657756..2658010 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Z9JGM5 |
| Locus tag | LPH64_RS11060 | Protein ID | WP_038273322.1 |
| Coordinates | 2657424..2657759 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH64_RS11035 (LPH64_11035) | 2652852..2654060 | + | 1209 | WP_038272829.1 | hypothetical protein | - |
| LPH64_RS11040 (LPH64_11040) | 2654562..2654882 | - | 321 | WP_038272832.1 | hypothetical protein | - |
| LPH64_RS11045 (LPH64_11045) | 2654954..2655670 | - | 717 | WP_160165226.1 | portal protein | - |
| LPH64_RS11050 (LPH64_11050) | 2655667..2656773 | - | 1107 | WP_114867106.1 | phage terminase large subunit | - |
| LPH64_RS11055 (LPH64_11055) | 2656770..2657171 | - | 402 | WP_114867107.1 | lysozyme | - |
| LPH64_RS11060 (LPH64_11060) | 2657424..2657759 | - | 336 | WP_038273322.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LPH64_RS11065 (LPH64_11065) | 2657756..2658010 | - | 255 | WP_038273324.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LPH64_RS11070 (LPH64_11070) | 2658112..2658810 | - | 699 | WP_114867108.1 | hypothetical protein | - |
| LPH64_RS11075 (LPH64_11075) | 2658767..2659960 | + | 1194 | WP_230428203.1 | hypothetical protein | - |
| LPH64_RS11080 (LPH64_11080) | 2659964..2660236 | + | 273 | WP_114867070.1 | VRR-NUC domain-containing protein | - |
| LPH64_RS11085 (LPH64_11085) | 2660238..2660588 | - | 351 | WP_114867109.1 | DUF1640 domain-containing protein | - |
| LPH64_RS11090 (LPH64_11090) | 2660664..2662010 | + | 1347 | WP_114867110.1 | DEAD/DEAH box helicase | - |
| LPH64_RS11095 (LPH64_11095) | 2662025..2662909 | + | 885 | WP_114867111.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2652852..2670865 | 18013 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9561.95 Da Isoelectric Point: 11.1842
>T226009 WP_038273324.1 NZ_CP087688:c2658010-2657756 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP
Download Length: 255 bp
>T226009 NZ_CP121660:380114-380605 [Sinorhizobium terangae]
ATGCCACTCTGGCGCGCCTTCGTGCCGCGCTGGGCTCATGTCCCGCTTTCCGGCGAGGGTGCGGCGCGCTTCGGCGGCCG
ATGGAATCCGGTCGGCATGCCGACCATCTACGCCGCGCGCGAACTTTCGACCGCCTGGGCCGAATACAACCAGGGTTTCG
TGCAGCATCCGGCGCTGATCGTACGGCTCGAGCTTTACGATGCGCGGCTGGCTGATCTCACGGACGCCCATGTTCTTGAG
GAGCTTGGCCTGACGGATGCCATCCACCGATGCGAATGGCGGGACGACCTCGACAAAGGCGCAGTGCCGCAGACCCACAA
GCTGCAGGCCGATCTCCTGGCCCGCGAATTTCACGGCGTGATCTACCCGTCTTTCATGTCGCCCGGCGGCACCTGCGTCG
CGCTCTGGCGCTGGAACGGCGCGGGTGCGCCACGCCTTGAGGTCATCGATCCAGAAGGCAGGCTGCCGAAATCGCCAGCC
TCCTGGCTTTAG
ATGCCACTCTGGCGCGCCTTCGTGCCGCGCTGGGCTCATGTCCCGCTTTCCGGCGAGGGTGCGGCGCGCTTCGGCGGCCG
ATGGAATCCGGTCGGCATGCCGACCATCTACGCCGCGCGCGAACTTTCGACCGCCTGGGCCGAATACAACCAGGGTTTCG
TGCAGCATCCGGCGCTGATCGTACGGCTCGAGCTTTACGATGCGCGGCTGGCTGATCTCACGGACGCCCATGTTCTTGAG
GAGCTTGGCCTGACGGATGCCATCCACCGATGCGAATGGCGGGACGACCTCGACAAAGGCGCAGTGCCGCAGACCCACAA
GCTGCAGGCCGATCTCCTGGCCCGCGAATTTCACGGCGTGATCTACCCGTCTTTCATGTCGCCCGGCGGCACCTGCGTCG
CGCTCTGGCGCTGGAACGGCGCGGGTGCGCCACGCCTTGAGGTCATCGATCCAGAAGGCAGGCTGCCGAAATCGCCAGCC
TCCTGGCTTTAG
Antitoxin
Download Length: 112 a.a. Molecular weight: 12318.98 Da Isoelectric Point: 4.7313
>AT226009 WP_038273322.1 NZ_CP087688:c2657759-2657424 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI
Download Length: 336 bp
>AT226009 NZ_CP121660:379665-380036 [Sinorhizobium terangae]
ATGGTCGCCCTCAACCTGGACATTCCCGCCGCCCGCTTCGGGGAGGATCATTCCCCGTTCCTGTCGGCGCGCCTTGTCGC
CGACCGTCTGGGCATAACGCTCGCCGAACTCGCCAAGCTGATTGGCGTCGCGCGGAACACGCTGACAGCCAAGAGCGGCG
CCCGCAAGGTCGATAGCGCCCTGAGCAGGGTCGTCCGCATCCTCGCCATGGCGTCCGAAATGGCGGGCGACGAGGCCCGC
GCCGTCATCTGGTTCAAGCATCAGCCGATCCCCGGCTGGGCCGGAAAGACGGCGTTCGATCTCGTCGGTGAAGGCAAGGC
CGACAAGGTGCTCGCTTATCTGGAAGCTGTTCGCGCCGGCGTCTACGCCTAG
ATGGTCGCCCTCAACCTGGACATTCCCGCCGCCCGCTTCGGGGAGGATCATTCCCCGTTCCTGTCGGCGCGCCTTGTCGC
CGACCGTCTGGGCATAACGCTCGCCGAACTCGCCAAGCTGATTGGCGTCGCGCGGAACACGCTGACAGCCAAGAGCGGCG
CCCGCAAGGTCGATAGCGCCCTGAGCAGGGTCGTCCGCATCCTCGCCATGGCGTCCGAAATGGCGGGCGACGAGGCCCGC
GCCGTCATCTGGTTCAAGCATCAGCCGATCCCCGGCTGGGCCGGAAAGACGGCGTTCGATCTCGTCGGTGAAGGCAAGGC
CGACAAGGTGCTCGCTTATCTGGAAGCTGTTCGCGCCGGCGTCTACGCCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|