Detailed information of TA system TA226004

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 937..1487
• Replicon: plasmid pPLS19A
• Accession: NZ_CP087687
• Organism: Xylella taiwanensis strain PLS19A

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LPH61_RS11950
• Protein ID: WP_230428324.1
• Coordinates: 1197..1487 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LPH61_RS11945
• Protein ID: WP_230428323.1
• Coordinates: 937..1209 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH61_RS11940 (LPH61_11940)	2..802	+	801	WP_230428322.1	replication initiation protein	-
LPH61_RS11945 (LPH61_11945)	937..1209	+	273	WP_230428323.1	CopG family ribbon-helix-helix protein	Antitoxin
LPH61_RS11950 (LPH61_11950)	1197..1487	+	291	WP_230428324.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH61_RS11955 (LPH61_11955)	1550..1810	+	261	WP_230428325.1	hypothetical protein	-
LPH61_RS11960 (LPH61_11960)	1871..2041	+	171	WP_230428326.1	hypothetical protein	-
LPH61_RS11965 (LPH61_11965)	2050..2550	+	501	WP_230428327.1	hypothetical protein	-
LPH61_RS11970 (LPH61_11970)	2550..2858	+	309	WP_230428328.1	TrbC/VirB2 family protein	-
LPH61_RS11975 (LPH61_11975)	2863..3246	+	384	WP_230428329.1	VirB3 family type IV secretion system protein	-
LPH61_RS11980 (LPH61_11980)	3209..5623	+	2415	WP_230428330.1	transporter	-
LPH61_RS11985 (LPH61_11985)	5626..6291	+	666	WP_230428331.1	type IV secretion system protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..32575	32575

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10949.64 Da
• Isoelectric Point: 10.2328

>T226004 WP_230428324.1 NZ_CP087687:1197-1487 [Xylella taiwanensis]
VPRVIWTPPALNDVQRLYRFLAPKDANVARRAVQAIRVGVKVLAHQPRVGRPVDAMDLEFREWLIDFGNSGYVVFYRFDG
ETAAILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T226004 NZ_CP121655:107530-107823 [Rhizobium sp. CB3171]
TTGAAGCTCATCTGGTCCGCCTTCGCGCTCGCCGATCGCGATGGCATCTTCACCCATATTGAGGCCGACAATCCGGCCGC
CGCCGCCTCGGTCGACGAACGGATTGCGGCCGCCGCCCGTCGTCTGCGGGATTTTCCGGAGAGCGGCCGTCCCGGCAGGA
TTGCCGGGACACGCGAGTTGGTGATTACCGGCACGCCTTATATCGCTGCCTATGTCGTGACGGAAACTGCAGTCCGCATT
CTCCGTGTCCTGCACGGCGCGCAGCAATGGCCCGAAGCTTTGCCCGAAGACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10628.87 Da
• Isoelectric Point: 5.1990

>AT226004 WP_230428323.1 NZ_CP087687:937-1209 [Xylella taiwanensis]
MATTIKLNDELRTRIQRLAGLRDRSAHWIMREAITQYVEREEKCDAFRQDAMRAWNEYQANGLHVTHEEADAWFAKLEAS
EDVEPPKCHE

Nucleotide

• Length: 273 bp

>AT226004 NZ_CP121655:107225-107533 [Rhizobium sp. CB3171]
ATGGCTGCAAATGCTCTCGTTCAAACCCGCATTGATTCCTCGGTTCGGGATCGTGCATCCGCCGTGCTCGAAAGCATGGG
GCTGACGGTTTCCGATGCCGTGCGGATCCTGCTCACCCGGACCGCCAATGAAGGTGCACTGCCGCTCGAACTGGTGACGA
GCAGCGAGACGCATGATGCCTGGTTCCGGGGCAAGGTGCTGGAGGCGCTGAACGATACGCGGCCCGATATCCCCGATGAT
GAGGTCGAGGCACACTTTGCGGAGCGGCGCGCGGCGGCACGCCGTAAGGCAGCCGACCTGAAACCTTGA