Detailed information of TA system TA226003

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2792926..2793611
• Replicon: chromosome
• Accession: NZ_CP087686
• Organism: Xylella taiwanensis strain PLS19A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LPH61_RS11790
• Protein ID: WP_038272463.1
• Coordinates: 2793195..2793611 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LPH61_RS11785
• Protein ID: WP_038272460.1
• Coordinates: 2792926..2793198 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH61_RS11750 (LPH61_11750)	2788153..2788740	+	588	WP_038273076.1	hypothetical protein	-
LPH61_RS11755 (LPH61_11755)	2789016..2789330	+	315	WP_230428211.1	hypothetical protein	-
LPH61_RS11760 (LPH61_11760)	2789333..2789539	+	207	WP_038273075.1	hypothetical protein	-
LPH61_RS11765 (LPH61_11765)	2789548..2789784	+	237	WP_230428212.1	major capsid protein	-
LPH61_RS11770 (LPH61_11770)	2789964..2791349	+	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH61_RS11775 (LPH61_11775)	2791352..2791696	+	345	WP_038273069.1	DUF2523 family protein	-
LPH61_RS11780 (LPH61_11780)	2791709..2792836	+	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH61_RS11785 (LPH61_11785)	2792926..2793198	+	273	WP_038272460.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LPH61_RS11790 (LPH61_11790)	2793195..2793611	+	417	WP_038272463.1	type II toxin-antitoxin system VapC family toxin	Toxin
LPH61_RS11795 (LPH61_11795)	2793674..2794018	-	345	WP_038272464.1	DUF3653 domain-containing protein	-
LPH61_RS11800 (LPH61_11800)	2794009..2794254	-	246	WP_230428284.1	hypothetical protein	-
LPH61_RS11805 (LPH61_11805)	2794838..2795452	-	615	WP_081755477.1	HNH endonuclease	-
LPH61_RS11810 (LPH61_11810)	2795728..2796201	-	474	WP_038272510.1	LEA type 2 family protein	-
LPH61_RS11815 (LPH61_11815)	2797046..2798257	+	1212	WP_038272508.1	signal recognition particle-docking protein FtsY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-52)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15195.91 Da
• Isoelectric Point: 6.9048

>T226003 WP_038272463.1 NZ_CP087686:2793195-2793611 [Xylella taiwanensis]
MSGYLLDTNIISDMIRNPFGLVACRIEKVDPKEVCTSIVVAAELRYGCAKKGSTKLLAKVKLMLETIPVLPLDIPTDAEY
GRIRAELESVGQTIGLNDLLIGTHAYVLGMTLVTDNVKEFKRIRGLKIENWLECASSV

Nucleotide

• Length: 417 bp

>T226003 NZ_CP121655:c4632-4336 [Rhizobium sp. CB3171]
ATGTTCTCGATACGCGAAACAGTCGAATTTTCGAATTGGATGCTGCGCTTGCGCGATGATCGGGCCAAAGCTCGAATTGG
TCAGCGCATTATGCGGCTCGCAAGTGGCAACGCTGGCGACGTGAAGCCAGTTGGCGAGGGCGTCAGTGAATTGCGTATCA
ACTACGGCCCGGGATATCGAGTCTACTTTGTCCGGGAGGGAAGCATTATGATCGTTCTCCTTTGCGGCGGAGACAAGAAA
ACGCAAAGCAGGGATATTGAACGCGCCAAGGCGCTGGCGAATGCGCTGAAGGAGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10331.95 Da
• Isoelectric Point: 4.5216

>AT226003 WP_038272460.1 NZ_CP087686:2792926-2793198 [Xylella taiwanensis]
MSISMPSSRLKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPVSMPTNIIELLAQWKTEDPLGLEDQFPEIE
DMLAKPDDIF

Nucleotide

• Length: 273 bp

>AT226003 NZ_CP121655:c4332-4027 [Rhizobium sp. CB3171]
ATGACGCTCAAGACACGAGAATTCGATCCAGCTCGCTACCTCGACAGCGAGGATGCAATTGACGAGTATATCTTGGCTGC
AAGCGAAAGCGGTGATCCTCATGAGCTCGCGGCGGCGCTCGGCGTCGTTGCAAAAGCGCGCGGGATTACAGAGGTGGCTC
GCAAGTCAGGGCTAACTCGGCAAGCAATCTACAAGGCACTCGATGAAGATGGGAATCCCGAATTAGGGACGATCGCGAGA
GTCGCTGACGCACTCGGCTTCAAACTTTCACTTGTGCCCAAAAGCGCCATCACGAAAGCTGCCTGA