Detailed information of TA system TA226002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2626861..2627447
• Replicon: chromosome
• Accession: NZ_CP087686
• Organism: Xylella taiwanensis strain PLS19A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH61_RS10930
• Protein ID: WP_038273324.1
• Coordinates: 2627193..2627447 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH61_RS10925
• Protein ID: WP_038273322.1
• Coordinates: 2626861..2627196 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH61_RS10900 (LPH61_10900)	2622289..2623497	+	1209	WP_038272829.1	hypothetical protein	-
LPH61_RS10905 (LPH61_10905)	2623999..2624319	-	321	WP_038272832.1	hypothetical protein	-
LPH61_RS10910 (LPH61_10910)	2624391..2625107	-	717	WP_160165226.1	portal protein	-
LPH61_RS10915 (LPH61_10915)	2625104..2626210	-	1107	WP_114867106.1	phage terminase large subunit	-
LPH61_RS10920 (LPH61_10920)	2626207..2626608	-	402	WP_114867107.1	lysozyme	-
LPH61_RS10925 (LPH61_10925)	2626861..2627196	-	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH61_RS10930 (LPH61_10930)	2627193..2627447	-	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH61_RS10935 (LPH61_10935)	2627549..2628247	-	699	WP_114867108.1	hypothetical protein	-
LPH61_RS10940 (LPH61_10940)	2628204..2629397	+	1194	WP_230428203.1	hypothetical protein	-
LPH61_RS10945 (LPH61_10945)	2629401..2629673	+	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH61_RS10950 (LPH61_10950)	2629675..2630025	-	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH61_RS10955 (LPH61_10955)	2630101..2631447	+	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH61_RS10960 (LPH61_10960)	2631462..2632346	+	885	WP_114867111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2622289..2641372	19083

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T226002 WP_038273324.1 NZ_CP087686:c2627447-2627193 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T226002 NZ_CP121655:c4332-4027 [Rhizobium sp. CB3171]
ATGACGCTCAAGACACGAGAATTCGATCCAGCTCGCTACCTCGACAGCGAGGATGCAATTGACGAGTATATCTTGGCTGC
AAGCGAAAGCGGTGATCCTCATGAGCTCGCGGCGGCGCTCGGCGTCGTTGCAAAAGCGCGCGGGATTACAGAGGTGGCTC
GCAAGTCAGGGCTAACTCGGCAAGCAATCTACAAGGCACTCGATGAAGATGGGAATCCCGAATTAGGGACGATCGCGAGA
GTCGCTGACGCACTCGGCTTCAAACTTTCACTTGTGCCCAAAAGCGCCATCACGAAAGCTGCCTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT226002 WP_038273322.1 NZ_CP087686:c2627196-2626861 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT226002 NZ_CP121655:c4632-4336 [Rhizobium sp. CB3171]
ATGTTCTCGATACGCGAAACAGTCGAATTTTCGAATTGGATGCTGCGCTTGCGCGATGATCGGGCCAAAGCTCGAATTGG
TCAGCGCATTATGCGGCTCGCAAGTGGCAACGCTGGCGACGTGAAGCCAGTTGGCGAGGGCGTCAGTGAATTGCGTATCA
ACTACGGCCCGGGATATCGAGTCTACTTTGTCCGGGAGGGAAGCATTATGATCGTTCTCCTTTGCGGCGGAGACAAGAAA
ACGCAAAGCAGGGATATTGAACGCGCCAAGGCGCTGGCGAATGCGCTGAAGGAGTAA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5