Detailed information of TA system TA226000

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-relB/-
• Location: 1820699..1821093
• Replicon: chromosome
• Accession: NZ_CP087686
• Organism: Xylella taiwanensis strain PLS19A

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: LPH61_RS07295
• Protein ID: WP_200866186.1
• Coordinates: 1820699..1820902 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Z9JJI0
• Locus tag: LPH61_RS07300
• Protein ID: WP_038270756.1
• Coordinates: 1820899..1821093 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH61_RS07275 (LPH61_07275)	1815713..1815853	+	141	WP_160165149.1	hypothetical protein	-
LPH61_RS07280 (LPH61_07280)	1816240..1817250	-	1011	WP_038270757.1	serine protease	-
LPH61_RS07285 (LPH61_07285)	1818486..1819877	+	1392	WP_051482280.1	right-handed parallel beta-helix repeat-containing protein	-
LPH61_RS07290 (LPH61_07290)	1819950..1820564	-	615	WP_230428270.1	recombinase family protein	-
LPH61_RS07295 (LPH61_07295)	1820699..1820902	-	204	WP_200866186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH61_RS07300 (LPH61_07300)	1820899..1821093	-	195	WP_038270756.1	hypothetical protein	Antitoxin
LPH61_RS07305 (LPH61_07305)	1821337..1821732	+	396	WP_230428271.1	DUF4158 domain-containing protein	-
LPH61_RS07310 (LPH61_07310)	1821771..1822241	+	471	WP_230428154.1	hypothetical protein	-
LPH61_RS07315 (LPH61_07315)	1822375..1822458	+	84	Protein_1443	type II toxin-antitoxin system RelE/ParE family toxin	-
LPH61_RS07320 (LPH61_07320)	1822570..1822851	+	282	WP_038270748.1	XRE family transcriptional regulator	-
LPH61_RS07325 (LPH61_07325)	1823121..1824250	-	1130	Protein_1445	DUF5710 domain-containing protein	-
LPH61_RS07330 (LPH61_07330)	1824426..1825263	+	838	Protein_1446	VirB8/TrbF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-61)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7625.95 Da
• Isoelectric Point: 11.2308

>T226000 WP_200866186.1 NZ_CP087686:c1820902-1820699 [Xylella taiwanensis]
MTLPLHWRTSARDDLASLIRFIAYENPLTARRMKVLIEASVLLASAHPYMFRPGRVPGTREIVAHPN

Nucleotide

• Length: 204 bp

>T226000 NZ_CP121653:c2736394-2735900 [Rhizobium sp. CB3171]
GTGACCCTCAGCGCACCGGCACCCCTAGCCGATCATCATGAGCTGGCCGAATTCAATTCCGGCGTCCCTGAACTGGACGA
CTGGCTGCGTCGCCGCGCCCGTTCCAATCAAGCAGGCGGGGCGCGGACCTTCGTCGTGTGCGAGGGAAGCCGCGTTATCG
CCTATTACGCGCTCGCCTCCGGCGCGGTAAGACAGCCGGAAGCACCTGGCCGTTTTCGGCGCAATATGCCTGATCCAATC
CCGGTCGCTGTGCTTGGACGCCTCGCCATTGATCAATCCTACCAGGGGCGTGGTTTTGGCAGGGCATTGGTGCGCGACGC
GGGCCTGCGCCTGCTCAATGCCGCTGAAATACTAGGCATCCGAGGCGTGCTGGTTCCTGCGATTTCAGATGACGCACGAG
CCTTCTATGAGGCTGTCGGCTTCCTGTCTTTTCCGTCCGACCCCATGATGCGGATGGTCGGATTGCCCGACCTCAACAAT
GCACTGAACCCCTAA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7289.11 Da
• Isoelectric Point: 4.5007

>AT226000 WP_038270756.1 NZ_CP087686:c1821093-1820899 [Xylella taiwanensis]
MKTTPLDPIISEFATEEQAASYDRWFRAKVQASLDDSRPSVPHDQVMAEMDAIIAEAEQHRKQT

Nucleotide

• Length: 195 bp

>AT226000 NZ_CP121653:c2736669-2736391 [Rhizobium sp. CB3171]
ATTCAGTCGGGGTTCATTCGCAAAGATCGGAGCCCGCTGAAACCGCGGACGACCCGCAACTTGATTGATCGCGCCGCTGA
GTTGCTCGGTAAGACGCGCACGGATTTCATTTTGGAGGCGTCCGAACGCCGTGCCGAAGAGATGCTGCCCGACCGCACTA
TCTTCACGGTAAGCCCCGAAATCTATGCCGAATACCTTGCCCGGCTCGATGCGCCTGCGCAGCTCAATGAGCGTCTAACA
CGCACCATGTCGACTAAAGCGCCATGGGATGAGGCGTGA

Structures

Antitoxin

• AlphaFold DB: Z9JJI0