Detailed information of TA system TA225996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2626809..2627395
• Replicon: chromosome
• Accession: NZ_CP087685
• Organism: Xylella taiwanensis strain PLS4A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH40_RS10895
• Protein ID: WP_038273324.1
• Coordinates: 2627141..2627395 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH40_RS10890
• Protein ID: WP_038273322.1
• Coordinates: 2626809..2627144 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH40_RS10865 (LPH40_10865)	2622237..2623445	+	1209	WP_038272829.1	hypothetical protein	-
LPH40_RS10870 (LPH40_10870)	2623947..2624267	-	321	WP_038272832.1	hypothetical protein	-
LPH40_RS10875 (LPH40_10875)	2624339..2625055	-	717	WP_160165226.1	portal protein	-
LPH40_RS10880 (LPH40_10880)	2625052..2626158	-	1107	WP_114867106.1	phage terminase large subunit	-
LPH40_RS10885 (LPH40_10885)	2626155..2626556	-	402	WP_114867107.1	lysozyme	-
LPH40_RS10890 (LPH40_10890)	2626809..2627144	-	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH40_RS10895 (LPH40_10895)	2627141..2627395	-	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH40_RS10900 (LPH40_10900)	2627497..2628195	-	699	WP_114867108.1	hypothetical protein	-
LPH40_RS10905 (LPH40_10905)	2628152..2629345	+	1194	WP_230428203.1	hypothetical protein	-
LPH40_RS10910 (LPH40_10910)	2629349..2629621	+	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH40_RS10915 (LPH40_10915)	2629623..2629973	-	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH40_RS10920 (LPH40_10920)	2630049..2631395	+	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH40_RS10925 (LPH40_10925)	2631410..2632294	+	885	WP_114867111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2622237..2640250	18013

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T225996 WP_038273324.1 NZ_CP087685:c2627395-2627141 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T225996 NZ_CP121652:3201376-3201630 [Rhizobium sp. CB3171]
ATGAATAGCAAGCAGATCAGGACTCTTGCCGCAGTTTTCAGAAACCCGGTATCCGGCACGATTGATTGGGCCGATATCGA
AAGTCTCCTCATCGCAACCGGCGCGAACATCATCGAAGGAAGTGGCTCGCGCGTGAAGTTCGAGAAAGACGGCGCGGTCG
CGAGCTTTCATCGCCCCCATCCGGACAAGGAAGCAAAGCGATATCAAGTTCGCGACGCCAGGGAATTCCTGATCCAAATC
GGAGTAACGCCGTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT225996 WP_038273322.1 NZ_CP087685:c2627144-2626809 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT225996 NZ_CP121652:3201627-3201983 [Rhizobium sp. CB3171]
GTGAACACCATGAGCTACAAGAGCTATCATGCCCGCATCGAATATGACGATGAAGATGAAATCTTTTTCGGCAAGATCGC
CGGCATTTCCGACGTCATCGGCTTTCATGCCGAAAGCGTCGCGGAACTTAAGAGTGCCTTTCACGAGGCTGTCGATGATT
ATATCGCCACTTGTCACCGGATTGGTAAGGAGCCGCAAAAGCCCTATTCCGGCAAGATGATGTTCAGAGTTGACCCGGAA
GTTCATCGTCGTGCCGCCATGGCTGCCGAGCTTTCCGGCAAGAGCCTGAATCAGTGGGCGGAGGAAGCCCTTGAAAAGGC
TGCCAAGCAGGCAGGTCAGACCCGACGGGCCGGATAA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5