Detailed information of TA system TA225994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-relB/-
• Location: 1820680..1821074
• Replicon: chromosome
• Accession: NZ_CP087685
• Organism: Xylella taiwanensis strain PLS4A

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: LPH40_RS07260
• Protein ID: WP_200866186.1
• Coordinates: 1820680..1820883 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Z9JJI0
• Locus tag: LPH40_RS07265
• Protein ID: WP_038270756.1
• Coordinates: 1820880..1821074 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH40_RS07240 (LPH40_07240)	1815694..1815834	+	141	WP_160165149.1	hypothetical protein	-
LPH40_RS07245 (LPH40_07245)	1816221..1817231	-	1011	WP_038270757.1	serine protease	-
LPH40_RS07250 (LPH40_07250)	1818467..1819858	+	1392	WP_051482280.1	right-handed parallel beta-helix repeat-containing protein	-
LPH40_RS07255 (LPH40_07255)	1819931..1820593	-	663	WP_268746643.1	recombinase family protein	-
LPH40_RS07260 (LPH40_07260)	1820680..1820883	-	204	WP_200866186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH40_RS07265 (LPH40_07265)	1820880..1821074	-	195	WP_038270756.1	hypothetical protein	Antitoxin
LPH40_RS07270 (LPH40_07270)	1821270..1821713	+	444	Protein_1435	DUF4158 domain-containing protein	-
LPH40_RS07275 (LPH40_07275)	1821752..1822222	+	471	WP_230428154.1	hypothetical protein	-
LPH40_RS07280 (LPH40_07280)	1822356..1822439	+	84	Protein_1437	type II toxin-antitoxin system RelE/ParE family toxin	-
LPH40_RS07285 (LPH40_07285)	1822551..1822832	+	282	WP_038270748.1	XRE family transcriptional regulator	-
LPH40_RS07290 (LPH40_07290)	1823102..1824231	-	1130	Protein_1439	DUF5710 domain-containing protein	-
LPH40_RS07295 (LPH40_07295)	1824407..1825244	+	838	Protein_1440	VirB8/TrbF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-61)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7625.95 Da
• Isoelectric Point: 11.2308

>T225994 WP_200866186.1 NZ_CP087685:c1820883-1820680 [Xylella taiwanensis]
MTLPLHWRTSARDDLASLIRFIAYENPLTARRMKVLIEASVLLASAHPYMFRPGRVPGTREIVAHPN

Nucleotide

• Length: 204 bp

>T225994 NZ_CP121652:2407979-2408233 [Rhizobium sp. CB3171]
ATGGATTGGCCATTGCAAGACGCCAAGAATCAATTCTCGAAAGTCGTGCAGAAGGCACGCAGCGAAGGTCCGCAAACTGT
GACACTGCGCGGCGAGCGCGCGGTCGTTGTTCTCTCCGCGGAAGACTATGACGCCTTGCGCGCGGGAAAGCCGAGCCTGG
TGGATGATCTGCTATCGGGGCCAGCCTGGGATGACGAGTTGGCTGACGCGGTGACAACGCGAGACAAGACGCCAAGCCGG
GATGTCGCCTTCTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7289.11 Da
• Isoelectric Point: 4.5007

>AT225994 WP_038270756.1 NZ_CP087685:c1821074-1820880 [Xylella taiwanensis]
MKTTPLDPIISEFATEEQAASYDRWFRAKVQASLDDSRPSVPHDQVMAEMDAIIAEAEQHRKQT

Nucleotide

• Length: 195 bp

>AT225994 NZ_CP121652:2408233-2408643 [Rhizobium sp. CB3171]
ATGTATCTGATCGATACCAATATCATTTCTGAAGCGCGTCGCGGCACTATCGAAGCGATATCCTGGCTGCGCATAGCCGA
CCCGTCGACCGTCTATCTCAGCGTCATCACACTCGGCGAAGTCATGCGCGGGATCGCCCTTAAGCGAAGGACCGATCCAC
GCGCCGCCGCACATCTGGAAGAATGGCTGCGCAAGCTTCGCCACGATCACAGCGGCCGCATCCTGCCAATCACGGACCAA
ATCGCCGTCGAATGGGGCCGCATCTCCGCGCTGCGCCCTCGCGGCGATGCCGACGGGCTGATCGCGGCCACTGCAATCGT
CCATGATCTGATTATCGTTACGCGCAATGTCAGCGATTTTGACGATGCCGGCGTGTCGGTGATCAATCCTTGGGATCAGG
CATCTTACTGA

Structures

Antitoxin

• AlphaFold DB: Z9JJI0