Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 8441..8982 | Replicon | chromosome |
| Accession | NZ_CP087685 | ||
| Organism | Xylella taiwanensis strain PLS4A | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Z9JGT1 |
| Locus tag | LPH40_RS00085 | Protein ID | WP_038273166.1 |
| Coordinates | 8659..8982 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | Z9JGL9 |
| Locus tag | LPH40_RS00080 | Protein ID | WP_038273164.1 |
| Coordinates | 8441..8662 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH40_RS00030 (LPH40_00030) | 4017..4253 | - | 237 | WP_230428212.1 | major capsid protein | - |
| LPH40_RS00035 (LPH40_00035) | 4262..4468 | - | 207 | WP_038273075.1 | hypothetical protein | - |
| LPH40_RS00040 (LPH40_00040) | 4471..4785 | - | 315 | WP_230428211.1 | hypothetical protein | - |
| LPH40_RS00045 (LPH40_00045) | 5061..5648 | - | 588 | WP_038273076.1 | hypothetical protein | - |
| LPH40_RS00050 (LPH40_00050) | 5845..5988 | - | 144 | WP_160165233.1 | hypothetical protein | - |
| LPH40_RS00055 (LPH40_00055) | 6108..6308 | - | 201 | WP_038273077.1 | hypothetical protein | - |
| LPH40_RS00060 (LPH40_00060) | 6357..6620 | - | 264 | WP_162814095.1 | hypothetical protein | - |
| LPH40_RS00065 (LPH40_00065) | 6624..6785 | - | 162 | WP_160165236.1 | hypothetical protein | - |
| LPH40_RS00070 (LPH40_00070) | 7075..7404 | + | 330 | WP_230428286.1 | DUF3693 domain-containing protein | - |
| LPH40_RS00075 (LPH40_00075) | 7493..7993 | - | 501 | Protein_14 | tyrosine-type recombinase/integrase | - |
| LPH40_RS00080 (LPH40_00080) | 8441..8662 | + | 222 | WP_038273164.1 | antitoxin MazE family protein | Antitoxin |
| LPH40_RS00085 (LPH40_00085) | 8659..8982 | + | 324 | WP_038273166.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LPH40_RS00090 (LPH40_00090) | 9083..10231 | - | 1149 | WP_069636227.1 | zonular occludens toxin domain-containing protein | - |
| LPH40_RS00095 (LPH40_00095) | 10231..10572 | - | 342 | WP_038273089.1 | DUF2523 family protein | - |
| LPH40_RS00100 (LPH40_00100) | 10576..11643 | - | 1068 | WP_152536670.1 | virulence factor TspB C-terminal domain-related protein | - |
| LPH40_RS00105 (LPH40_00105) | 12111..12329 | - | 219 | WP_051482398.1 | major capsid protein | - |
| LPH40_RS00110 (LPH40_00110) | 12338..12547 | - | 210 | WP_230428208.1 | hypothetical protein | - |
| LPH40_RS00115 (LPH40_00115) | 12547..12840 | - | 294 | WP_038273093.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 965..20350 | 19385 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 11807.97 Da Isoelectric Point: 9.1188
>T225993 WP_038273166.1 NZ_CP087685:8659-8982 [Xylella taiwanensis]
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
Download Length: 324 bp
>T225993 NZ_CP121652:c1705986-1705705 [Rhizobium sp. CB3171]
GTGATCGTTTCATACAAGGGGAAGTTCGCCGAAGCTGTGGCCTCAGGAAACGTGCCAAAGGGCTTTCCAGCCGACCTCGT
TCGTTCCGCGCAACGCAAGCTGACGATATTGAACTATGCGGTTGTGCTGGACGACCTGCGATCGCCTCCCGGCAATCGGC
TGGAGCGTTTGCAAGGTGATCGTTCTGGCCAGTATTCGATCAGAATCAACGACCAATGGCGCATTTGCTTCCTATGGACC
GAAGCTGGACCGCGTGATGTTGAGATCGTGGATTACCACTGA
GTGATCGTTTCATACAAGGGGAAGTTCGCCGAAGCTGTGGCCTCAGGAAACGTGCCAAAGGGCTTTCCAGCCGACCTCGT
TCGTTCCGCGCAACGCAAGCTGACGATATTGAACTATGCGGTTGTGCTGGACGACCTGCGATCGCCTCCCGGCAATCGGC
TGGAGCGTTTGCAAGGTGATCGTTCTGGCCAGTATTCGATCAGAATCAACGACCAATGGCGCATTTGCTTCCTATGGACC
GAAGCTGGACCGCGTGATGTTGAGATCGTGGATTACCACTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8490.65 Da Isoelectric Point: 8.0827
>AT225993 WP_038273164.1 NZ_CP087685:8441-8662 [Xylella taiwanensis]
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
Download Length: 222 bp
>AT225993 NZ_CP121652:c1705693-1705394 [Rhizobium sp. CB3171]
ATGACCGAGACCAAACTTCCGCCGATCCATCCGGGTGAAATCTTGCGGGAGGAGTATCTGAAGCCATTGACGATGAGCGC
CGGTGCTTTGGCGAAACATCTTAACGTGCCTCGAACGCGTATTGAGAGGCTGGTTTCGGAGGAGACCGGGGTCACGGCGG
ATACGGCACTTCGGCTCGCGCGGTTTTTCAGCACGACGCCAGATTTCTGGATGGCGATGCAAACGGGTTATGATCTCGCG
ATCGCGCAAGCGGAAAAGAGCGATGTATTCGCGGCCATCAAGCCGCTTGAAGCGGCTTAA
ATGACCGAGACCAAACTTCCGCCGATCCATCCGGGTGAAATCTTGCGGGAGGAGTATCTGAAGCCATTGACGATGAGCGC
CGGTGCTTTGGCGAAACATCTTAACGTGCCTCGAACGCGTATTGAGAGGCTGGTTTCGGAGGAGACCGGGGTCACGGCGG
ATACGGCACTTCGGCTCGCGCGGTTTTTCAGCACGACGCCAGATTTCTGGATGGCGATGCAAACGGGTTATGATCTCGCG
ATCGCGCAAGCGGAAAAGAGCGATGTATTCGCGGCCATCAAGCCGCTTGAAGCGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|