Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1140276..1140835 Replicon chromosome
Accession NC_010161
Organism Bartonella tribocorum CIP 105476

Toxin (Protein)


Gene name parE Uniprot ID A9IPY8
Locus tag BTR_RS05070 Protein ID WP_012231080.1
Coordinates 1140276..1140548 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5B9CWB1
Locus tag BTR_RS05075 Protein ID WP_012231079.1
Coordinates 1140545..1140835 (-) Length 97 a.a.

Genomic Context

BTR_RS05090BTR_RS05095BTR_RS05100BTR_RS05065BTR_RS05070BTR_RS05075BTR_RS13125BTR_RS05080BTR_RS05085
Location: 1143315..1143938 (624 bp)
Type: Others
Protein ID: WP_012231664.1
Location: 1144449..1144667 (219 bp)
Type: Others
Protein ID: WP_005773872.1
Location: 1144672..1144944 (273 bp)
Type: Others
Protein ID: WP_012231665.1
Location: 1139127..1140095 (969 bp)
Type: Others
Protein ID: WP_081458160.1
Location: 1140276..1140548 (273 bp)
Type: Toxin
Protein ID: WP_012231080.1
Location: 1140545..1140835 (291 bp)
Type: Antitoxin
Protein ID: WP_012231079.1
Location: 1141293..1141442 (150 bp)
Type: Others
Protein ID: WP_169309788.1
Location: 1141539..1141739 (201 bp)
Type: Others
Protein ID: WP_012231078.1
Location: 1141940..1143104 (1165 bp)
Type: Others
Protein ID: Protein_953
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BTR_RS050651139127..1140095-969WP_081458160.1DUF3987 domain-containing protein-
BTR_RS050701140276..1140548-273WP_012231080.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
BTR_RS050751140545..1140835-291WP_012231079.1hypothetical proteinAntitoxin
BTR_RS131251141293..1141442-150WP_169309788.1hypothetical protein-
BTR_RS050801141539..1141739-201WP_012231078.1DNA-binding protein-
BTR_RS050851141940..1143104-1165Protein_953integrase arm-type DNA-binding domain-containing protein-
BTR_RS050901143315..1143938+624WP_012231664.1DNA adenine methylase-
BTR_RS050951144449..1144667+219WP_005773872.1hypothetical protein-
BTR_RS051001144672..1144944+273WP_012231665.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1108117..119168383566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10612.57 Da        Isoelectric Point: 10.9313

>T22599 WP_012231080.1 NC_010161:c1140548-1140276 [Bartonella tribocorum CIP 105476]
MKLIWTQVARVDRKKIREYISQNNPSAALKFDQLLSEKIEKLVKFSTLGRLGRVVNTREFIVHPNYIMIYDISDGVVRIL
RVLHTKQKFP

Download         Length: 273 bp

>T22599 NC_010161:c1140548-1140276 [Bartonella tribocorum CIP 105476]
ATGAAGCTAATTTGGACACAAGTAGCACGCGTTGACCGCAAAAAGATACGTGAATACATATCACAAAATAATCCTTCTGC
TGCCTTAAAGTTTGATCAACTTTTATCTGAAAAGATAGAAAAACTCGTTAAGTTTTCTACTCTTGGTCGTTTAGGACGAG
TTGTAAATACACGTGAATTTATTGTACATCCAAATTATATCATGATTTATGATATTTCAGATGGCGTTGTTCGTATTTTA
CGTGTGCTTCATACAAAGCAAAAATTCCCTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11078.46 Da        Isoelectric Point: 5.2356

>AT22599 WP_012231079.1 NC_010161:c1140835-1140545 [Bartonella tribocorum CIP 105476]
MAETTFTFRVDDVLKNEFSKAAKACDRSGAQLLRDYMRDIVKEQKERSAHDLWFREQVQLGINSANAGDIISSEEIEAEA
KEWRLKIQSKLDRSTL

Download         Length: 291 bp

>AT22599 NC_010161:c1140835-1140545 [Bartonella tribocorum CIP 105476]
ATGGCTGAGACGACATTTACCTTTCGCGTTGATGATGTATTGAAAAATGAATTTTCCAAAGCAGCAAAAGCGTGTGATAG
ATCTGGTGCACAATTGTTGCGAGATTATATGCGCGATATCGTAAAAGAACAAAAAGAAAGAAGTGCACACGATTTATGGT
TTCGGGAACAGGTTCAATTAGGGATAAATTCTGCTAATGCAGGCGATATAATATCTTCTGAGGAAATCGAAGCAGAAGCA
AAGGAATGGCGCTTAAAAATACAAAGTAAACTAGATAGATCAACTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA9IPY8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5B9CWB1

References