22599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1140276..1140835 Replicon chromosome
Accession NC_010161
Organism Bartonella tribocorum CIP 105476

Toxin (Protein)


Gene name parE Uniprot ID A9IPY8
Locus tag BTR_RS05070 Protein ID WP_012231080.1
Coordinates 1140276..1140548 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5B9CWB1
Locus tag BTR_RS05075 Protein ID WP_012231079.1
Coordinates 1140545..1140835 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTR_RS05065 1139127..1140095 - 969 WP_081458160.1 DUF3987 domain-containing protein -
BTR_RS05070 1140276..1140548 - 273 WP_012231080.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BTR_RS05075 1140545..1140835 - 291 WP_012231079.1 hypothetical protein Antitoxin
BTR_RS13125 1141293..1141442 - 150 WP_169309788.1 hypothetical protein -
BTR_RS05080 1141539..1141739 - 201 WP_012231078.1 DNA-binding protein -
BTR_RS05085 1141940..1143104 - 1165 Protein_953 integrase arm-type DNA-binding domain-containing protein -
BTR_RS05090 1143315..1143938 + 624 WP_012231664.1 DNA adenine methylase -
BTR_RS05095 1144449..1144667 + 219 WP_005773872.1 hypothetical protein -
BTR_RS05100 1144672..1144944 + 273 WP_012231665.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1108117..1191683 83566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10612.57 Da        Isoelectric Point: 10.9313

>T22599 WP_012231080.1 NC_010161:c1140548-1140276 [Bartonella tribocorum CIP 105476]
MKLIWTQVARVDRKKIREYISQNNPSAALKFDQLLSEKIEKLVKFSTLGRLGRVVNTREFIVHPNYIMIYDISDGVVRIL
RVLHTKQKFP

Download         Length: 273 bp

>T22599 NC_010161:c1140548-1140276 [Bartonella tribocorum CIP 105476]
ATGAAGCTAATTTGGACACAAGTAGCACGCGTTGACCGCAAAAAGATACGTGAATACATATCACAAAATAATCCTTCTGC
TGCCTTAAAGTTTGATCAACTTTTATCTGAAAAGATAGAAAAACTCGTTAAGTTTTCTACTCTTGGTCGTTTAGGACGAG
TTGTAAATACACGTGAATTTATTGTACATCCAAATTATATCATGATTTATGATATTTCAGATGGCGTTGTTCGTATTTTA
CGTGTGCTTCATACAAAGCAAAAATTCCCTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11078.46 Da        Isoelectric Point: 5.2356

>AT22599 WP_012231079.1 NC_010161:c1140835-1140545 [Bartonella tribocorum CIP 105476]
MAETTFTFRVDDVLKNEFSKAAKACDRSGAQLLRDYMRDIVKEQKERSAHDLWFREQVQLGINSANAGDIISSEEIEAEA
KEWRLKIQSKLDRSTL

Download         Length: 291 bp

>AT22599 NC_010161:c1140835-1140545 [Bartonella tribocorum CIP 105476]
ATGGCTGAGACGACATTTACCTTTCGCGTTGATGATGTATTGAAAAATGAATTTTCCAAAGCAGCAAAAGCGTGTGATAG
ATCTGGTGCACAATTGTTGCGAGATTATATGCGCGATATCGTAAAAGAACAAAAAGAAAGAAGTGCACACGATTTATGGT
TTCGGGAACAGGTTCAATTAGGGATAAATTCTGCTAATGCAGGCGATATAATATCTTCTGAGGAAATCGAAGCAGAAGCA
AAGGAATGGCGCTTAAAAATACAAAGTAAACTAGATAGATCAACTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9IPY8

Antitoxin

Source ID Structure
AlphaFold DB A0A5B9CWB1

References