Detailed information of TA system TA225987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1256907..1257493
• Replicon: chromosome
• Accession: NZ_CP087683
• Organism: Xylella taiwanensis strain PLS1135

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH44_RS05375
• Protein ID: WP_038273324.1
• Coordinates: 1257239..1257493 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH44_RS05370
• Protein ID: WP_038273322.1
• Coordinates: 1256907..1257242 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH44_RS05345 (LPH44_05345)	1252335..1253543	+	1209	WP_038272829.1	hypothetical protein	-
LPH44_RS05350 (LPH44_05350)	1254045..1254365	-	321	WP_038272832.1	hypothetical protein	-
LPH44_RS05355 (LPH44_05355)	1254437..1255153	-	717	WP_160165226.1	portal protein	-
LPH44_RS05360 (LPH44_05360)	1255150..1256232	-	1083	WP_051482382.1	phage terminase large subunit	-
LPH44_RS05365 (LPH44_05365)	1256253..1256654	-	402	WP_114867107.1	lysozyme	-
LPH44_RS05370 (LPH44_05370)	1256907..1257242	-	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH44_RS05375 (LPH44_05375)	1257239..1257493	-	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH44_RS05380 (LPH44_05380)	1257595..1258293	-	699	WP_114867108.1	hypothetical protein	-
LPH44_RS05385 (LPH44_05385)	1258250..1259443	+	1194	WP_230428203.1	hypothetical protein	-
LPH44_RS05390 (LPH44_05390)	1259447..1259719	+	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH44_RS05395 (LPH44_05395)	1259721..1260071	-	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH44_RS05400 (LPH44_05400)	1260147..1261493	+	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH44_RS05405 (LPH44_05405)	1261508..1262392	+	885	WP_114867111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1252335..1270348	18013

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T225987 WP_038273324.1 NZ_CP087683:c1257493-1257239 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T225987 NZ_CP121650:6045825-6046106 [Bradyrhizobium sp. CB82]
GTGATCAGGACGTTCCGAGACAGAGCGACGGAAGCCGTATTCAATGGCGAAGCTCCGAAGGGCTTCCCTGCTGATTTGGT
GAAGGTCGCACGCCGGAAGCTGCGCTATCTTCATGCAGCCGACAATCTCAGTGACCTGCGGTCGCCTCCGGGGAATCGAC
TGGAAGCTCTGGCGGGCAATCGCCGAGGACAGCACTCGATCAGGATCAACGACCAGTTCCGGATCTGCTTTGTTTGGACG
GCGGAAGGTCCCGCCGAAGTCGAGATCGTGGACTATCACTAG

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT225987 WP_038273322.1 NZ_CP087683:c1257242-1256907 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT225987 NZ_CP121650:6046119-6046424 [Bradyrhizobium sp. CB82]
ATGGCTAAGAAACTCAAGCCGATGCATCCTGGTGAGGTTCTGCGGGAAGAATTTCTGGTCCCGCTGAACACGTCTGCGGG
CGCGCTTGCAAAGGCCTGTGGCCTGCCCCGTACAAGAATTGAGCGTATTGCGAGCGAGCAAACCGGGATCACTGCCGATA
CTGCACTTCGGCTCGCCAAGGCGCTCGGCACGACAGCCCAGCTTTGGCTCAATTTGCAGAACGACTACGACATTCAGATC
GCCAAGCGCGAACTAGGCAAGGTCCTGGATCGGATTGAGACTGTGAACAAGCCGAAGGCGGCCTGA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5