Detailed information of TA system TA225985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-relB/-
• Location: 450736..451130
• Replicon: chromosome
• Accession: NZ_CP087683
• Organism: Xylella taiwanensis strain PLS1135

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: LPH44_RS01740
• Protein ID: WP_200866186.1
• Coordinates: 450736..450939 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Z9JJI0
• Locus tag: LPH44_RS01745
• Protein ID: WP_038270756.1
• Coordinates: 450936..451130 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH44_RS01720 (LPH44_01720)	445750..445890	+	141	WP_160165149.1	hypothetical protein	-
LPH44_RS01725 (LPH44_01725)	446277..447287	-	1011	WP_038270757.1	serine protease	-
LPH44_RS01730 (LPH44_01730)	448523..449914	+	1392	WP_051482280.1	right-handed parallel beta-helix repeat-containing protein	-
LPH44_RS01735 (LPH44_01735)	449987..450649	-	663	WP_268746643.1	recombinase family protein	-
LPH44_RS01740 (LPH44_01740)	450736..450939	-	204	WP_200866186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH44_RS01745 (LPH44_01745)	450936..451130	-	195	WP_038270756.1	hypothetical protein	Antitoxin
LPH44_RS01750 (LPH44_01750)	451326..451769	+	444	Protein_336	DUF4158 domain-containing protein	-
LPH44_RS01755 (LPH44_01755)	451898..452278	+	381	WP_038270750.1	hypothetical protein	-
LPH44_RS01760 (LPH44_01760)	452412..452495	+	84	Protein_338	type II toxin-antitoxin system RelE/ParE family toxin	-
LPH44_RS01765 (LPH44_01765)	452607..452888	+	282	WP_038270748.1	XRE family transcriptional regulator	-
LPH44_RS01770 (LPH44_01770)	453158..454287	-	1130	Protein_340	DUF5710 domain-containing protein	-
LPH44_RS01775 (LPH44_01775)	454463..455300	+	838	Protein_341	VirB8/TrbF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-61)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7625.95 Da
• Isoelectric Point: 11.2308

>T225985 WP_200866186.1 NZ_CP087683:c450939-450736 [Xylella taiwanensis]
MTLPLHWRTSARDDLASLIRFIAYENPLTARRMKVLIEASVLLASAHPYMFRPGRVPGTREIVAHPN

Nucleotide

• Length: 204 bp

>T225985 NZ_CP121647:c7999966-7999670 [Bradyrhizobium sp. CB3481]
ATGATTTCCAATTTCCGGGATGATTGGCTGCGCGCGTTCTTCGTGGATGACGTTCACTCGCGAAACGTCCCGCCGGATTT
GGAGAGTCGCCTTTTTCGCAAGCTACAGATGCTCGACGATGCAACGACCGATCAGGACTTGCGCGTGCCGCCAAGCAACC
ATTTCGAGAAGCTGCGTGGTAAACTGGAAGGATTTCACTCGATCCGCGTCAACAGCCAATGGCGGCTCATCTTTCGATGG
GATGGCCGGCGCGGCGAAGCATCGGGCGTCTATCTCGATGATCATAGCTATCGCTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7289.11 Da
• Isoelectric Point: 4.5007

>AT225985 WP_038270756.1 NZ_CP087683:c451130-450936 [Xylella taiwanensis]
MKTTPLDPIISEFATEEQAASYDRWFRAKVQASLDDSRPSVPHDQVMAEMDAIIAEAEQHRKQT

Nucleotide

• Length: 195 bp

>AT225985 NZ_CP121647:c7999661-7999353 [Bradyrhizobium sp. CB3481]
ATGTTGATGACGAAACGCAAGCCGGCAACAGTCGGAGAAATCCTGGCTCAGGAATTCATGGAGCCAATGAGCCTTACGCA
GAGCGCGCTGGCAAAGGCCATGGGTGTGCAGCGCAAGCACGTCAACGAATTGTGCAACGATCGCCGGGCTATAACAGCTC
CTACCGCACTCATTCTTGCCCGCGTGTTCGGCAACAGTCCCGACTTCTGGCTCAACGTGCAGCGGCGAAGCGACATCTGG
GAGGCGATGCACTCGCCGCGCGAGCGCGAACGTATCAAGCGCGCCCGCCCCATTGGAGCGGCTGCGTGA

Structures

Antitoxin

• AlphaFold DB: Z9JJI0